Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   SR187_RS04435 Genome accession   NZ_AP018400
Coordinates   915672..916409 (+) Length   245 a.a.
NCBI ID   WP_120171637.1    Uniprot ID   A0A2Z5TMH0
Organism   Streptococcus ruminantium strain GUT-187     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 910672..921409
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SR187_RS04415 (SR187_4530) - 910754..912022 (+) 1269 WP_120171635.1 dihydroorotase -
  SR187_RS04420 (SR187_4535) nt5e 912292..914361 (+) 2070 WP_156019180.1 cell surface ecto-5'-nucleotidase Nt5e -
  SR187_RS10045 - 914842..915126 (-) 285 WP_228026686.1 hypothetical protein -
  SR187_RS10260 (SR187_4540) - 915480..915641 (+) 162 WP_079276155.1 LytTR family transcriptional regulator DNA-binding domain-containing protein -
  SR187_RS04435 (SR187_4545) comE/blpR 915672..916409 (+) 738 WP_120171637.1 response regulator transcription factor Regulator
  SR187_RS04440 (SR187_4550) - 916423..917763 (+) 1341 WP_120171638.1 GHKL domain-containing protein -
  SR187_RS04445 (SR187_4555) - 917820..917945 (-) 126 WP_079276156.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  SR187_RS04455 - 918238..918471 (+) 234 WP_120171640.1 bacteriocin -
  SR187_RS04460 (SR187_4565) - 918471..918782 (+) 312 WP_162496986.1 bacteriocin immunity protein -
  SR187_RS04465 (SR187_4570) - 919074..919298 (+) 225 WP_120171641.1 hypothetical protein -
  SR187_RS04470 (SR187_4575) - 919574..920206 (-) 633 WP_120171642.1 ABC transporter ATP-binding protein -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28493.94 Da        Isoelectric Point: 7.1059

>NTDB_id=69452 SR187_RS04435 WP_120171637.1 915672..916409(+) (comE/blpR) [Streptococcus ruminantium strain GUT-187]
MNIFVLEDDIIQQTRIEKVLNNLLEKHKIEPKKLIISGKPEQLIASVEEKGAHQLFFLDIEIRSEELKGLKVAKQIRDID
PYAIIIFVTTHSEFMPLSFRYQVSALDYIEKELATKEFESRIETALLYAVSKDSKTVAEDSFYFKSKYAQVQYPFDEVYY
VETSPRPHRVILYTRTDCMEFTASLSDILKQEKRLVQCHRSFLINPANVSKIDRQAKVVYFPNGTHCLVARKKLDVTLAT
IDQLH

Nucleotide


Download         Length: 738 bp        

>NTDB_id=69452 SR187_RS04435 WP_120171637.1 915672..916409(+) (comE/blpR) [Streptococcus ruminantium strain GUT-187]
ATGAATATATTTGTACTAGAAGATGATATTATACAACAAACAAGGATTGAAAAAGTGCTTAACAATCTTTTGGAGAAACA
TAAAATAGAGCCCAAAAAACTTATTATTTCTGGGAAACCCGAACAGTTGATTGCTTCAGTGGAGGAGAAAGGGGCGCACC
AGTTGTTCTTTTTGGATATTGAGATAAGATCAGAAGAACTTAAAGGTCTTAAAGTCGCTAAACAAATCAGAGATATTGAT
CCTTATGCTATTATTATTTTTGTGACGACGCATTCTGAATTTATGCCTCTCTCTTTTCGTTATCAAGTATCAGCATTAGA
TTATATTGAAAAGGAACTAGCAACGAAAGAATTTGAATCTCGCATAGAAACAGCTTTACTGTATGCAGTGAGTAAAGATA
GTAAAACAGTAGCTGAGGATTCTTTCTATTTCAAATCTAAATATGCCCAAGTTCAGTACCCATTTGATGAAGTTTACTAT
GTTGAAACATCTCCAAGACCACATAGGGTTATCCTTTATACAAGAACTGATTGTATGGAGTTCACCGCCAGTTTATCAGA
TATTTTAAAGCAAGAAAAGAGACTGGTACAGTGTCATCGTTCGTTTCTTATCAATCCTGCAAATGTTAGCAAAATAGATA
GACAAGCCAAAGTTGTTTATTTTCCCAATGGGACACATTGTTTGGTTGCAAGAAAAAAATTAGATGTTACTTTGGCGACT
ATAGACCAGCTGCACTGA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-234)

Response regulator receiver domain (Response_reg)

(3-122)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2Z5TMH0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

52.066

98.776

0.514
  comE/comE1 Streptococcus equinus JB1

41.423

97.551

0.404

Multiple sequence alignment