Detailed information NTG0681708

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: M1F46_RS09840
• Genome accession: NZ_CP096539
• Coordinates: 1998991..2000034 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain RIVM_M047065
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1993991..2005034

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
M1F46_RS09810 (M1F46_09805)	-	1994412..1995668 (-)	1257	WP_074347694.1	aminopeptidase	-
M1F46_RS09815 (M1F46_09810)	-	1995671..1995871 (-)	201	WP_000180460.1	DUF1128 family protein	-
M1F46_RS09820 (M1F46_09815)	-	1996018..1996482 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
M1F46_RS09825 (M1F46_09820)	-	1996489..1996764 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
M1F46_RS09830 (M1F46_09825)	-	1997042..1998259 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
M1F46_RS09835 (M1F46_09830)	vraR	1998372..1999001 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
M1F46_RS09840 (M1F46_09835)	vraS	1998991..2000034 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
M1F46_RS09845 (M1F46_09840)	liaF	2000031..2000732 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
M1F46_RS09850 (M1F46_09845)	-	2000747..2001133 (-)	387	WP_001110182.1	hypothetical protein	-
M1F46_RS09855 (M1F46_09850)	map	2001350..2002108 (-)	759	WP_000636145.1	type I methionyl aminopeptidase	-
M1F46_RS09860 (M1F46_09855)	-	2002692..2003678 (+)	987	WP_000999712.1	aromatic acid exporter family protein	-
M1F46_RS09865 (M1F46_09860)	-	2003867..2004280 (-)	414	WP_025174370.1	hypothetical protein	-
M1F46_RS09870 (M1F46_09865)	-	2004309..2004419 (-)	111	WP_014937049.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=681708 M1F46_RS09840 WP_001017131.1 1998991..2000034(-) (vraS) [Staphylococcus aureus strain RIVM_M047065]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=681708 M1F46_RS09840 WP_001017131.1 1998991..2000034(-) (vraS) [Staphylococcus aureus strain RIVM_M047065]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1