Detailed information NTG0067526

Bioinformatically predicted

Overview

• Name: ccrA
• Type: Machinery gene
• Locus tag: JMUB0001_RS00330
• Genome accession: NZ_AP014956
• Coordinates: 64363..65709 (-)
• Length: 448 a.a.
• NCBI ID: WP_000816499.1
• Uniprot ID: Q9R3W9
• Organism: Staphylococcus capitis strain TW2795
• Function: promote SCCmec transfer (predicted from homology) Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
SCCmec	44220..65709	64363..65709	within	0

Gene organization within MGE regions

Location: 44220..65709

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
JMUB0001_RS00205 (JMUB0001_36)	mecA	44220..46229 (-)	2010	WP_001801873.1	PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA	-
JMUB0001_RS00210 (JMUB0001_37)	mecR1	46326..48083 (+)	1758	WP_000952923.1	beta-lactam sensor/signal transducer MecR1	-
JMUB0001_RS00215 (JMUB0001_38)	mecI	48083..48454 (+)	372	WP_000369214.1	mecA-type methicillin resistance repressor MecI	-
JMUB0001_RS12240	psm-mec	48539..48607 (-)	69	WP_014532405.1	phenol-soluble modulin PSM-mec	-
JMUB0001_RS00225 (JMUB0001_40)	-	48941..50071 (+)	1131	WP_010922808.1	ROK family transcriptional regulator	-
JMUB0001_RS00235 (JMUB0001_42)	cstB	50185..51519 (-)	1335	Protein_41	persulfide dioxygenase-sulfurtransferase CstB	-
JMUB0001_RS00240 (JMUB0001_43)	-	51552..52616 (-)	1065	WP_000438836.1	DsrE/DsrF/DrsH-like family protein	-
JMUB0001_RS00245 (JMUB0001_44)	cstR	52752..53012 (+)	261	WP_000220507.1	persulfide-sensing transcriptional repressor CstR	-
JMUB0001_RS00250 (JMUB0001_45)	-	53012..53650 (+)	639	Protein_44	sulfite exporter TauE/SafE family protein	-
JMUB0001_RS00260 (JMUB0001_46)	-	53995..54657 (-)	663	WP_001092058.1	class I SAM-dependent methyltransferase	-
JMUB0001_RS00275 (JMUB0001_47)	erm(A)	55166..55897 (+)	732	WP_001072201.1	23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A)	-
JMUB0001_RS00280 (JMUB0001_48)	-	56023..56805 (-)	783	WP_000067268.1	aminoglycoside nucleotidyltransferase ANT(9)-Ia	-
JMUB0001_RS00285 (JMUB0001_49)	-	56956..57333 (-)	378	WP_000361059.1	DUF6262 family protein	-
JMUB0001_RS00290 (JMUB0001_50)	-	57340..59232 (-)	1893	WP_001557544.1	site-specific integrase	-
JMUB0001_RS00295 (JMUB0001_51)	-	59229..60314 (-)	1086	WP_000868132.1	tyrosine-type recombinase/integrase	-
JMUB0001_RS00300	-	60433..60756 (-)	324	WP_000088091.1	JAB domain-containing protein	-
JMUB0001_RS00305	-	60749..60955 (-)	207	WP_001077283.1	hypothetical protein	-
JMUB0001_RS00310 (JMUB0001_52)	-	60957..61478 (-)	522	WP_000836008.1	DUF1643 domain-containing protein	-
JMUB0001_RS00315 (JMUB0001_53)	-	61497..61808 (-)	312	WP_000833212.1	DUF960 family protein	-
JMUB0001_RS00320 (JMUB0001_54)	-	61893..62243 (-)	351	WP_000171449.1	SAUGI family uracil-DNA glycosylase inhibitor	-
JMUB0001_RS00325 (JMUB0001_55)	ccrB	62714..64342 (-)	1629	WP_001186596.1	recombinase family protein	Machinery gene
JMUB0001_RS00330 (JMUB0001_56)	ccrA	64363..65709 (-)	1347	WP_000816499.1	recombinase family protein	Machinery gene

Sequence

Protein

• Length: 448 a.a.
• Molecular weight: 52138.19 Da
• Isoelectric Point: 10.1760

>NTDB_id=67526 JMUB0001_RS00330 WP_000816499.1 64363..65709(-) (ccrA) [Staphylococcus capitis strain TW2795]
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA

Nucleotide

• Length: 1347 bp

>NTDB_id=67526 JMUB0001_RS00330 WP_000816499.1 64363..65709(-) (ccrA) [Staphylococcus capitis strain TW2795]
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA

Domains

Predicted by InterproScan.

• Recombinase (Recombinase) (168-250)

• Recombinase zinc beta ribbon domain (Zn_ribbon_recom) (262-321)

• Resolvase, N terminal domain (Resolvase) (4-147)

3D structure

• AlphaFold DB: Q9R3W9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ccrA	Staphylococcus aureus COL	78.174	100	0.783
ccrA	Staphylococcus aureus N315	72.383	100	0.725