Detailed information    

insolico Bioinformatically predicted

Overview


Name   comK/comK1   Type   Regulator
Locus tag   MUO47_RS00145 Genome accession   NZ_CP094923
Coordinates   29358..29927 (-) Length   189 a.a.
NCBI ID   WP_000287265.1    Uniprot ID   A0A7U7EXU5
Organism   Staphylococcus aureus strain 1824     
Function   promote expression of competence genes (predicted from homology)   
Competence regulation

Related MGE


Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1..30355 29358..29927 within 0


Gene organization within MGE regions


Location: 1..30355
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MUO47_RS00010 (MUO47_00010) - 1367..2605 (+) 1239 WP_031773897.1 phage portal protein -
  MUO47_RS00015 (MUO47_00015) - 2589..3362 (+) 774 WP_031773898.1 head maturation protease, ClpP-related -
  MUO47_RS00020 (MUO47_00020) - 3374..4537 (+) 1164 WP_001142734.1 phage major capsid protein -
  MUO47_RS00025 (MUO47_00025) - 4606..4884 (+) 279 WP_031775145.1 head-tail connector protein -
  MUO47_RS00030 (MUO47_00030) - 4896..5228 (+) 333 WP_000395499.1 hypothetical protein -
  MUO47_RS00035 (MUO47_00035) - 5225..5626 (+) 402 WP_000110019.1 hypothetical protein -
  MUO47_RS00040 (MUO47_00040) - 5627..6022 (+) 396 WP_001636966.1 DUF3168 domain-containing protein -
  MUO47_RS00045 (MUO47_00045) - 6057..6698 (+) 642 WP_000807542.1 major tail protein -
  MUO47_RS00050 (MUO47_00050) - 6790..7245 (+) 456 WP_000169130.1 Ig-like domain-containing protein -
  MUO47_RS00055 (MUO47_00055) - 7303..7653 (+) 351 WP_000589165.1 hypothetical protein -
  MUO47_RS00060 (MUO47_00060) - 7695..7853 (+) 159 WP_000438833.1 hypothetical protein -
  MUO47_RS00065 (MUO47_00065) - 7867..14067 (+) 6201 WP_277445886.1 phage tail tape measure protein -
  MUO47_RS00070 (MUO47_00070) - 14067..14891 (+) 825 WP_001190533.1 phage tail family protein -
  MUO47_RS00075 (MUO47_00075) - 14900..16483 (+) 1584 WP_000384474.1 prophage endopeptidase tail family protein -
  MUO47_RS00080 (MUO47_00080) - 16483..16773 (+) 291 WP_000179860.1 hypothetical protein -
  MUO47_RS00085 (MUO47_00085) - 16789..18699 (+) 1911 WP_000429551.1 minor structural protein -
  MUO47_RS00090 (MUO47_00090) - 18699..20165 (+) 1467 WP_088811197.1 BppU family phage baseplate upper protein -
  MUO47_RS00095 (MUO47_00095) - 20165..20554 (+) 390 WP_088811196.1 DUF2977 domain-containing protein -
  MUO47_RS00100 (MUO47_00100) - 20547..20711 (+) 165 WP_000916020.1 XkdX family protein -
  MUO47_RS00105 (MUO47_00105) - 20757..21056 (+) 300 WP_088811195.1 DUF2951 domain-containing protein -
  MUO47_RS00110 (MUO47_00110) - 21192..21494 (+) 303 WP_000339141.1 phage holin -
  MUO47_RS00115 (MUO47_00115) - 21505..22959 (+) 1455 WP_278182356.1 N-acetylmuramoyl-L-alanine amidase -
  MUO47_RS00120 (MUO47_00120) - 23522..25846 (+) 2325 WP_001795272.1 S1C family serine protease -
  MUO47_RS00125 (MUO47_00125) - 25863..27221 (+) 1359 WP_000021865.1 TrkH family potassium uptake protein -
  MUO47_RS00130 (MUO47_00130) - 27360..28871 (+) 1512 WP_031929757.1 bifunctional UDP-sugar hydrolase/5'-nucleotidase -
  MUO47_RS00145 (MUO47_00145) comK/comK1 29358..29927 (-) 570 WP_000287265.1 competence protein ComK Regulator
  MUO47_RS00150 (MUO47_00150) - 30137..30355 (+) 219 WP_000876826.1 IDEAL domain-containing protein -

Sequence


Protein


Download         Length: 189 a.a.        Molecular weight: 22601.83 Da        Isoelectric Point: 9.6091

>NTDB_id=673970 MUO47_RS00145 WP_000287265.1 29358..29927(-) (comK/comK1) [Staphylococcus aureus strain 1824]
MYSQNIYVIRKGDMVIRPAFDDDDQRNGSEIIRFDKTRIQNPFKVQKIIERSCKFYGNTYLGKKAETNRITGISSKPPIL
LTPLFPTYFFPTHSDRQNENIWLNMHYIESIKELKNRKCKVTFINNESIILHVSYHSLWHQYNNSIFYYYMVDKQSRMIS
KNPDQPIDYNKATLNVFEALTRYSLFEDK

Nucleotide


Download         Length: 570 bp        

>NTDB_id=673970 MUO47_RS00145 WP_000287265.1 29358..29927(-) (comK/comK1) [Staphylococcus aureus strain 1824]
ATGTATTCTCAAAATATTTATGTGATACGCAAAGGAGACATGGTTATTCGACCAGCATTTGATGATGACGATCAAAGAAA
CGGTAGTGAAATAATTCGGTTTGACAAAACGCGTATTCAAAATCCTTTTAAAGTCCAGAAAATCATTGAACGCTCTTGCA
AATTTTATGGTAATACTTATCTTGGCAAGAAAGCAGAGACAAACCGCATTACTGGCATTTCTAGTAAACCACCTATTTTA
CTAACACCATTATTTCCAACTTATTTTTTCCCAACACATTCTGACAGACAAAATGAAAATATTTGGTTAAATATGCATTA
TATCGAAAGTATTAAAGAATTAAAAAATCGTAAATGTAAAGTGACATTTATTAATAATGAATCTATCATTCTTCATGTTT
CATACCACAGTTTATGGCATCAATATAACAATTCCATTTTTTACTATTACATGGTAGATAAACAATCTCGCATGATATCA
AAAAATCCCGACCAACCAATAGATTATAATAAAGCCACATTGAATGTGTTTGAAGCATTGACACGCTATTCTTTATTTGA
AGATAAATAA

Domains


Predicted by InterproScan.

(5-156)


Secondary structure


Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure


Source ID Structure
  AlphaFold DB A0A7U7EXU5

Transmembrane helices


Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.



Visualization of predicted probability:


Similar proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comK/comK1 Staphylococcus aureus MW2

100

100

1

  comK/comK1 Staphylococcus aureus N315

100

100

1