Detailed information NTG0067331

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: JSA_RS09965
• Genome accession: NZ_AP014921
• Coordinates: 1953918..1954961 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain JH4899
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1948918..1959961

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
JSA_RS09935 (JSA_1778)	-	1949336..1950592 (-)	1257	WP_001795438.1	aminopeptidase	-
JSA_RS09940 (JSA_1779)	-	1950595..1950795 (-)	201	WP_000180461.1	DUF1128 family protein	-
JSA_RS09945 (JSA_1780)	-	1950942..1951406 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
JSA_RS09950 (JSA_1781)	-	1951413..1951688 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
JSA_RS09955 (JSA_1782)	-	1951966..1953183 (+)	1218	WP_000037069.1	YihY/virulence factor BrkB family protein	-
JSA_RS09960 (JSA_1783)	vraR	1953299..1953928 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
JSA_RS09965 (JSA_1784)	vraS	1953918..1954961 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
JSA_RS09970 (JSA_1785)	liaF	1954958..1955659 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
JSA_RS09975 (JSA_1786)	-	1955674..1956060 (-)	387	WP_001110179.1	hypothetical protein	-
JSA_RS09980 (JSA_1787)	map	1956277..1957035 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
JSA_RS09990 (JSA_1788)	-	1957622..1958608 (+)	987	WP_000999713.1	FUSC family protein	-
JSA_RS10000 (JSA_1789)	-	1959098..1959511 (-)	414	WP_001549145.1	hypothetical protein	-
JSA_RS10005	-	1959540..1959650 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=67331 JSA_RS09965 WP_001017131.1 1953918..1954961(-) (vraS) [Staphylococcus aureus strain JH4899]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=67331 JSA_RS09965 WP_001017131.1 1953918..1954961(-) (vraS) [Staphylococcus aureus strain JH4899]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1