Detailed information NTG0672908

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MUA37_RS04670
• Genome accession: NZ_CP094803
• Coordinates: 976330..977373 (+)
• Length: 347 a.a.
• NCBI ID: WP_002509180.1
• Uniprot ID: A0A7V7SQH4
• Organism: Staphylococcus arlettae strain IVB6235
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 971330..982373

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MUA37_RS04645 (MUA37_04640)	-	972006..972731 (+)	726	WP_002509175.1	type 1 glutamine amidotransferase	-
MUA37_RS04650 (MUA37_04645)	-	973222..974208 (-)	987	WP_135024393.1	aromatic acid exporter family protein	-
MUA37_RS04655 (MUA37_04650)	map	974374..975126 (+)	753	WP_262624861.1	type I methionyl aminopeptidase	-
MUA37_RS04660 (MUA37_04655)	-	975229..975615 (+)	387	WP_002509178.1	hypothetical protein	-
MUA37_RS04665 (MUA37_04660)	liaF	975632..976333 (+)	702	WP_002509179.1	cell wall-active antibiotics response protein LiaF	-
MUA37_RS04670 (MUA37_04665)	vraS	976330..977373 (+)	1044	WP_002509180.1	sensor histidine kinase	Regulator
MUA37_RS04675 (MUA37_04670)	vraR	977363..977992 (+)	630	WP_002509181.1	response regulator transcription factor	Regulator
MUA37_RS04680 (MUA37_04675)	-	978053..979132 (-)	1080	WP_142019533.1	YihY/virulence factor BrkB family protein	-
MUA37_RS04685 (MUA37_04680)	-	979412..979696 (-)	285	WP_002509183.1	hypothetical protein	-
MUA37_RS04690 (MUA37_04685)	-	979703..980167 (-)	465	WP_002509184.1	low molecular weight protein-tyrosine-phosphatase	-
MUA37_RS04695 (MUA37_04690)	-	980303..980506 (+)	204	WP_142019535.1	DUF1128 family protein	-
MUA37_RS04700 (MUA37_04695)	-	980518..981756 (+)	1239	WP_112369296.1	aminopeptidase	-
MUA37_RS04705 (MUA37_04700)	-	981796..982317 (+)	522	WP_002509187.1	acyl-CoA thioesterase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 39859.16 Da
• Isoelectric Point: 5.2631

>NTDB_id=672908 MUA37_RS04670 WP_002509180.1 976330..977373(+) (vraS) [Staphylococcus arlettae strain IVB6235]
MNHYIRAIGSMLILVYSTLIAFFFIDKIFVNIMYFQGMFYTQIFGIPVFLFLNLLIILLCIIVGSVLAYKINQQNHWLQT
QIERSIEGETVGINDQDIELYNETIELYQTLVPLNQEVHKLRMKTQNLTNESYNLNDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESQLTPPLDQQIPTLEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVVDLQKKVPMKVIHDI
EDFTVPKGIEDHLFRITQEAISNTLRHSNGTKVTIELFNQEAYLLLRIQDNGIGFNVDDKAEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLDKEDIDAN

Nucleotide

• Length: 1044 bp

>NTDB_id=672908 MUA37_RS04670 WP_002509180.1 976330..977373(+) (vraS) [Staphylococcus arlettae strain IVB6235]
ATGAATCACTACATTAGAGCAATAGGCTCTATGCTAATATTAGTATATAGTACATTAATTGCTTTTTTCTTTATAGATAA
AATATTTGTAAATATTATGTATTTTCAAGGTATGTTTTATACCCAAATATTTGGTATTCCAGTATTTTTATTTTTAAATT
TGCTCATAATTTTATTATGTATCATTGTAGGATCGGTTTTAGCTTATAAAATAAACCAGCAAAACCATTGGCTACAAACA
CAAATTGAACGTTCAATTGAAGGAGAAACAGTAGGGATTAATGACCAAGATATAGAACTTTATAATGAAACTATAGAGCT
CTATCAAACGTTAGTTCCACTCAATCAAGAAGTACATAAACTGCGAATGAAGACCCAAAATTTAACAAATGAATCTTATA
ATTTAAACGATGTCAAAGTTAAAAAAATAATCGAAGATGAACGACAAAGATTGGCTAGGGAATTACATGATTCAGTGAGT
CAGCAACTTTTTGCAGCTAGCATGATGTTATCAGCTATCAAAGAATCCCAATTAACACCACCGTTAGATCAACAAATCCC
TACATTAGAAAAAATGGTACAAGATTCTCAACTAGAAATGAGAGCATTATTACTACATTTAAGACCAATTGGTTTAAAAG
ATAAGTCTCTCGGCGAAGGTATTAAAGATTTAGTTGTCGATTTACAGAAAAAAGTACCAATGAAGGTCATACATGATATT
GAAGATTTTACTGTACCTAAAGGTATTGAAGATCATTTGTTTCGTATTACGCAAGAAGCGATATCCAATACATTACGTCA
TTCCAACGGTACAAAAGTAACAATTGAATTATTTAATCAAGAAGCATATTTATTATTACGTATTCAAGATAACGGTATTG
GTTTTAACGTAGATGATAAAGCTGAACAAAGTTATGGATTGAAAAATATGCGGGAGCGTGCATTAGAAATAGGTGCCACA
TTCCATATTGTATCGCTGCCTGATTCAGGTACTAGAATAGAAGTGAAAGCACCATTAGATAAGGAGGATATAGATGCCAA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase (HisKA_3) (147-210)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

3D structure

• AlphaFold DB: A0A7V7SQH4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	88.63	98.847	0.876