Detailed information NTG0672475

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MUA59_RS09870
• Genome accession: NZ_CP094782
• Coordinates: 1969949..1970992 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain IVB6172
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1964949..1975992

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MUA59_RS09840 (MUA59_09810)	-	1965367..1966623 (-)	1257	WP_001793428.1	aminopeptidase	-
MUA59_RS09845 (MUA59_09815)	-	1966626..1966826 (-)	201	WP_000180462.1	DUF1128 family protein	-
MUA59_RS09850 (MUA59_09820)	-	1966973..1967437 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
MUA59_RS09855 (MUA59_09825)	-	1967444..1967719 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
MUA59_RS09860 (MUA59_09830)	-	1967997..1969214 (+)	1218	WP_000037088.1	YihY/virulence factor BrkB family protein	-
MUA59_RS09865 (MUA59_09835)	vraR	1969330..1969959 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
MUA59_RS09870 (MUA59_09840)	vraS	1969949..1970992 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
MUA59_RS09875 (MUA59_09845)	liaF	1970989..1971690 (-)	702	WP_262613776.1	cell wall-active antibiotics response protein LiaF	-
MUA59_RS09880 (MUA59_09850)	-	1971705..1972091 (-)	387	WP_001110179.1	hypothetical protein	-
MUA59_RS09885 (MUA59_09855)	map	1972308..1973066 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
MUA59_RS09890 (MUA59_09860)	-	1973595..1974581 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
MUA59_RS09895 (MUA59_09865)	-	1974955..1975368 (-)	414	WP_262538798.1	hypothetical protein	-
MUA59_RS09900 (MUA59_09870)	-	1975397..1975509 (-)	113	Protein_1914	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=672475 MUA59_RS09870 WP_001017131.1 1969949..1970992(-) (vraS) [Staphylococcus aureus strain IVB6172]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=672475 MUA59_RS09870 WP_001017131.1 1969949..1970992(-) (vraS) [Staphylococcus aureus strain IVB6172]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCTCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1