Detailed information NTG0672241

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MUA50_RS04660
• Genome accession: NZ_CP094772
• Coordinates: 951314..952357 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain IVB6196
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 946314..957357

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MUA50_RS04630 (MUA50_04625)	-	946757..946867 (+)	111	WP_001790257.1	hypothetical protein	-
MUA50_RS04635 (MUA50_04630)	-	946896..947309 (+)	414	WP_001643743.1	hypothetical protein	-
MUA50_RS04640 (MUA50_04635)	-	947498..948484 (-)	987	WP_001014423.1	aromatic acid exporter family protein	-
MUA50_RS04645 (MUA50_04640)	map	949240..949998 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
MUA50_RS04650 (MUA50_04645)	-	950215..950601 (+)	387	WP_001110178.1	hypothetical protein	-
MUA50_RS04655 (MUA50_04650)	liaF	950616..951317 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
MUA50_RS04660 (MUA50_04655)	vraS	951314..952357 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
MUA50_RS04665 (MUA50_04660)	vraR	952347..952976 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
MUA50_RS04670 (MUA50_04665)	-	953089..954306 (-)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
MUA50_RS04675 (MUA50_04670)	-	954584..954859 (-)	276	WP_069631803.1	hypothetical protein	-
MUA50_RS04680 (MUA50_04675)	-	954866..955330 (-)	465	WP_000228670.1	low molecular weight protein-tyrosine-phosphatase	-
MUA50_RS04685 (MUA50_04680)	-	955477..955677 (+)	201	WP_000180460.1	DUF1128 family protein	-
MUA50_RS04690 (MUA50_04685)	-	955680..956936 (+)	1257	WP_001793983.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=672241 MUA50_RS04660 WP_001017131.1 951314..952357(+) (vraS) [Staphylococcus aureus strain IVB6196]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=672241 MUA50_RS04660 WP_001017131.1 951314..952357(+) (vraS) [Staphylococcus aureus strain IVB6196]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGACTT
ATACCATACACTTGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1