Detailed information NTG0671526

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MUA15_RS04620
• Genome accession: NZ_CP094733
• Coordinates: 991496..992542 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain IVB6194
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 986496..997542

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MUA15_RS04595 (MUA15_04580)	-	987637..988173 (+)	537	WP_262619653.1	hypothetical protein	-
MUA15_RS04600 (MUA15_04585)	-	988324..989310 (-)	987	WP_001830388.1	aromatic acid exporter family protein	-
MUA15_RS04605 (MUA15_04590)	map	989484..990239 (+)	756	WP_001830397.1	type I methionyl aminopeptidase	-
MUA15_RS04610 (MUA15_04595)	-	990397..990783 (+)	387	WP_001830382.1	hypothetical protein	-
MUA15_RS04615 (MUA15_04600)	liaF	990798..991499 (+)	702	WP_001830436.1	cell wall-active antibiotics response protein LiaF	-
MUA15_RS04620 (MUA15_04605)	vraS	991496..992542 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
MUA15_RS04625 (MUA15_04610)	vraR	992532..993161 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
MUA15_RS04630 (MUA15_04615)	-	993218..994396 (-)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
MUA15_RS04635 (MUA15_04620)	-	994803..995087 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
MUA15_RS04640 (MUA15_04625)	-	995095..995559 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
MUA15_RS04645 (MUA15_04630)	-	995700..995915 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
MUA15_RS04650 (MUA15_04635)	-	995917..997158 (+)	1242	WP_001832467.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=671526 MUA15_RS04620 WP_001830374.1 991496..992542(+) (vraS) [Staphylococcus epidermidis strain IVB6194]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=671526 MUA15_RS04620 WP_001830374.1 991496..992542(+) (vraS) [Staphylococcus epidermidis strain IVB6194]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92