Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   MUA74_RS00335 Genome accession   NZ_CP094720
Coordinates   77891..79240 (-) Length   449 a.a.
NCBI ID   WP_262609284.1    Uniprot ID   A0A9Q9NBR5
Organism   Staphylococcus sp. IVB6233     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 39174..112376 77891..79240 within 0


Gene organization within MGE regions


Location: 39174..112376
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MUA74_RS00180 (MUA74_00180) - 40947..41285 (+) 339 WP_262609261.1 SAUGI family uracil-DNA glycosylase inhibitor -
  MUA74_RS00185 (MUA74_00185) - 41381..41692 (+) 312 WP_262609262.1 DUF960 domain-containing protein -
  MUA74_RS00190 (MUA74_00190) - 41707..42210 (+) 504 WP_031912425.1 DUF1643 domain-containing protein -
  MUA74_RS00195 (MUA74_00195) - 42224..42445 (+) 222 WP_262609263.1 hypothetical protein -
  MUA74_RS00200 (MUA74_00200) - 42556..43773 (-) 1218 WP_262609264.1 restriction endonuclease subunit S -
  MUA74_RS00205 (MUA74_00205) - 43766..45322 (-) 1557 WP_262609265.1 type I restriction-modification system subunit M -
  MUA74_RS00210 (MUA74_00210) - 45439..48231 (-) 2793 WP_262609266.1 type I restriction endonuclease subunit R -
  MUA74_RS00215 (MUA74_00215) - 48458..49470 (+) 1013 Protein_40 hypothetical protein -
  MUA74_RS00220 (MUA74_00220) - 49566..50315 (+) 750 WP_262559916.1 hypothetical protein -
  MUA74_RS00225 (MUA74_00225) - 50357..51334 (+) 978 WP_262609268.1 DUF1002 domain-containing protein -
  MUA74_RS00230 (MUA74_00230) - 51483..52271 (-) 789 WP_262609553.1 nucleotidyltransferase domain-containing protein -
  MUA74_RS00235 (MUA74_00235) - 52523..53767 (-) 1245 WP_262609269.1 Shedu immune nuclease family protein -
  MUA74_RS00240 (MUA74_00240) - 54909..55370 (+) 462 WP_262609270.1 abortive infection system antitoxin AbiGi family protein -
  MUA74_RS00245 (MUA74_00245) - 55539..55727 (+) 189 WP_262609271.1 plantaricin C family lantibiotic -
  MUA74_RS00250 (MUA74_00250) - 55751..55957 (+) 207 WP_262609272.1 class II lanthipeptide, LchA2/BrtA2 family -
  MUA74_RS00255 (MUA74_00255) lanM 55976..58873 (+) 2898 WP_262609273.1 type 2 lanthipeptide synthetase LanM -
  MUA74_RS00260 (MUA74_00260) - 58875..61031 (+) 2157 WP_262609274.1 peptidase domain-containing ABC transporter -
  MUA74_RS00265 (MUA74_00265) lanM 61034..63793 (+) 2760 WP_262609275.1 type 2 lanthipeptide synthetase LanM -
  MUA74_RS00270 (MUA74_00270) - 63812..64909 (+) 1098 WP_262609276.1 hypothetical protein -
  MUA74_RS00275 (MUA74_00275) - 64924..65793 (+) 870 WP_262609277.1 ABC transporter ATP-binding protein -
  MUA74_RS00280 (MUA74_00280) - 65777..66502 (+) 726 WP_262609278.1 ABC transporter permease -
  MUA74_RS00285 (MUA74_00285) - 66531..66704 (+) 174 WP_198618760.1 hypothetical protein -
  MUA74_RS00290 (MUA74_00290) - 67409..67720 (+) 312 WP_262609279.1 antibiotic biosynthesis monooxygenase -
  MUA74_RS00295 (MUA74_00295) - 68358..71105 (+) 2748 WP_262609280.1 DNA methyltransferase -
  MUA74_RS00300 (MUA74_00300) - 71095..73041 (+) 1947 WP_175528680.1 DEAD/DEAH box helicase -
  MUA74_RS00305 (MUA74_00305) - 73044..74174 (+) 1131 WP_197945456.1 GIY-YIG nuclease family protein -
  MUA74_RS00310 (MUA74_00310) - 74268..74489 (-) 222 WP_175528681.1 hypothetical protein -
  MUA74_RS00315 (MUA74_00315) - 74504..75013 (-) 510 WP_262609281.1 DUF1643 domain-containing protein -
  MUA74_RS00320 (MUA74_00320) - 75028..75339 (-) 312 WP_053017467.1 DUF960 domain-containing protein -
  MUA74_RS00325 (MUA74_00325) - 75426..75776 (-) 351 WP_262609282.1 SAUGI family uracil-DNA glycosylase inhibitor -
  MUA74_RS00330 (MUA74_00330) ccrB 76242..77870 (-) 1629 WP_262609283.1 recombinase family protein Machinery gene
  MUA74_RS00335 (MUA74_00335) ccrA 77891..79240 (-) 1350 WP_262609284.1 recombinase family protein Machinery gene
  MUA74_RS00340 (MUA74_00340) - 79432..79707 (-) 276 WP_046099761.1 hypothetical protein -
  MUA74_RS00345 (MUA74_00345) - 79776..81563 (-) 1788 WP_262609285.1 DUF927 domain-containing protein -
  MUA74_RS00350 (MUA74_00350) - 81563..81856 (-) 294 WP_262609286.1 single-stranded DNA-binding protein -
  MUA74_RS00355 (MUA74_00355) - 81993..83042 (+) 1050 WP_262609287.1 ACP synthase -
  MUA74_RS00360 (MUA74_00360) - 83191..83868 (+) 678 WP_262609288.1 hypothetical protein -
  MUA74_RS00365 (MUA74_00365) - 84140..84271 (+) 132 Protein_70 IS3 family transposase -
  MUA74_RS00370 (MUA74_00370) - 84461..87190 (+) 2730 WP_262609289.1 ATP-dependent RecD-like DNA helicase -
  MUA74_RS00375 (MUA74_00375) - 87298..87693 (-) 396 Protein_72 ATP-binding protein -
  MUA74_RS00380 (MUA74_00380) - 87753..88535 (-) 783 WP_262609290.1 hypothetical protein -
  MUA74_RS00385 (MUA74_00385) - 88766..89221 (+) 456 WP_262609291.1 DeoR family transcriptional regulator -
  MUA74_RS00390 (MUA74_00390) - 89824..91887 (+) 2064 WP_262605592.1 heavy metal translocating P-type ATPase -
  MUA74_RS00395 (MUA74_00395) - 92076..92363 (+) 288 WP_262605593.1 transposase -
  MUA74_RS00400 (MUA74_00400) - 92375..93091 (+) 717 WP_262605928.1 IS3 family transposase -
  MUA74_RS00405 (MUA74_00405) - 93520..94593 (-) 1074 WP_262609292.1 IS30 family transposase -
  MUA74_RS00410 (MUA74_00410) - 94849..104643 (+) 9795 WP_262609293.1 YSIRK-type signal peptide-containing protein -
  MUA74_RS00415 (MUA74_00415) - 105173..105679 (+) 507 WP_019469178.1 hypothetical protein -
  MUA74_RS00420 (MUA74_00420) - 105697..107172 (+) 1476 WP_262605596.1 DUF6038 family protein -
  MUA74_RS00425 (MUA74_00425) - 107397..108497 (+) 1101 WP_262605597.1 DNA polymerase -
  MUA74_RS00430 (MUA74_00430) - 108490..108858 (+) 369 WP_262605598.1 hypothetical protein -
  MUA74_RS00435 (MUA74_00435) - 108858..110477 (+) 1620 WP_262605599.1 DUF5906 domain-containing protein -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 52401.97 Da        Isoelectric Point: 9.8831

>NTDB_id=671185 MUA74_RS00335 WP_262609284.1 77891..79240(-) (ccrA) [Staphylococcus sp. IVB6233]
MKQAIGYLRQSTTKQQSLPAQKQAIKTLAEKHNIQHITFYSDKQSGRTDKRNGYQQITELIQQGQFDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKINIFISLAELESDNIGEQVKNGIKEKAKQGKMITTHAPFGYHYH
NGTFTIDTVKAPTIKAVFNYYLQGYGYKKIAQYLEADDKFINRKPYQVRNIILNPNYCGRVINQYGQYENMFPAIVSTTI
YEEAQVTRTQKQVKRKPSENQLKQKIKCPYCYSTLTNTTVRKPDHSLRYYVCPQNMNNARFVCEFKGINAQELETSVLTT
CQDFFQNQQLYSKINQTIQQQLKRQRDIETKTTLNHEQLIEKLANGKIDAETFREQTQSLCQQSKPISSIHTHQIRKALQ
NVIQQRFTLNMLYPYIDEIHITKSKTLTGIYFKNEPLNIVNQTAQSSIA

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=671185 MUA74_RS00335 WP_262609284.1 77891..79240(-) (ccrA) [Staphylococcus sp. IVB6233]
ATGAAACAAGCAATTGGCTATTTACGTCAAAGTACAACTAAGCAACAATCACTTCCGGCACAGAAACAAGCCATCAAGAC
ATTGGCTGAAAAACACAATATTCAACACATCACATTTTATAGCGATAAGCAATCAGGACGCACTGATAAGCGGAATGGTT
ACCAACAAATTACTGAACTGATTCAACAAGGACAATTTGACGTACTATGTTGCTATCGTCTAAATCGACTTCATCGTAAT
CTAAAAAATGCATTAAAACTCATGAAATTGTGTCAAAAATACCATGTTCATATCTTAAGCGTTCATGATGGCTATTTTGA
TATGGATAAAGCATTCGATCGGCTCAAAATCAATATTTTCATCAGCTTGGCCGAATTAGAATCTGATAATATAGGCGAAC
AAGTCAAAAATGGAATCAAAGAAAAAGCGAAACAAGGTAAAATGATTACAACACATGCACCCTTTGGGTATCACTATCAT
AATGGTACTTTCACAATAGACACAGTAAAAGCACCAACAATAAAAGCTGTGTTCAATTATTACCTTCAAGGTTATGGTTA
TAAAAAAATTGCGCAATACTTAGAAGCTGATGATAAATTCATTAATCGCAAGCCCTATCAAGTGCGTAATATTATCCTTA
ACCCTAATTACTGTGGCCGGGTTATCAATCAATACGGACAATATGAAAACATGTTCCCAGCTATTGTCAGTACAACGATA
TACGAAGAAGCTCAAGTTACCCGAACTCAGAAACAAGTAAAACGTAAGCCGTCAGAAAATCAACTCAAACAAAAAATCAA
ATGTCCCTATTGTTATTCGACACTCACAAACACGACTGTCCGAAAACCAGATCATTCATTGCGTTACTATGTCTGTCCGC
AAAATATGAATAACGCTCGCTTTGTTTGTGAATTTAAAGGAATCAACGCACAAGAATTAGAAACAAGTGTCTTAACGACT
TGTCAGGACTTCTTTCAGAACCAACAGCTGTATTCAAAAATTAACCAAACAATTCAACAACAACTCAAAAGACAAAGAGA
CATAGAAACTAAAACTACACTCAACCACGAACAGCTAATAGAAAAATTGGCCAACGGCAAAATTGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTATGTCAACAATCCAAACCTATATCATCAATCCATACGCATCAAATTCGAAAGGCTTTACAA
AATGTCATTCAACAACGTTTCACGTTAAACATGTTGTACCCTTACATCGATGAAATTCATATTACCAAAAGTAAAACGCT
TACAGGTATCTATTTCAAAAATGAGCCCTTAAACATCGTCAATCAAACAGCACAATCATCGATTGCTTAA

Domains

Predicted by InterproScan.

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-322)

Recombinase (Recombinase)

(170-249)

Resolvase, N terminal domain (Resolvase)

(4-147)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus COL

91.537

100

0.915
  ccrA Staphylococcus aureus N315

74.165

100

0.742