Detailed information NTG0671023

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MUA72_RS04330
• Genome accession: NZ_CP094714
• Coordinates: 955897..956940 (+)
• Length: 347 a.a.
• NCBI ID: WP_050330549.1
• Uniprot ID: A0A0K1ACB9
• Organism: Staphylococcus schleiferi strain IVB6176
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 950897..961940

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MUA72_RS04305 (MUA72_04295)	-	951319..952458 (+)	1140	WP_242678349.1	exo-alpha-sialidase	-
MUA72_RS04310 (MUA72_04300)	-	952842..953840 (-)	999	WP_194368683.1	aromatic acid exporter family protein	-
MUA72_RS04315 (MUA72_04305)	map	953938..954699 (+)	762	WP_167732697.1	type I methionyl aminopeptidase	-
MUA72_RS04320 (MUA72_04310)	-	954797..955186 (+)	390	WP_016425509.1	hypothetical protein	-
MUA72_RS04325 (MUA72_04315)	liaF	955199..955900 (+)	702	WP_016425508.1	cell wall-active antibiotics response protein LiaF	-
MUA72_RS04330 (MUA72_04320)	vraS	955897..956940 (+)	1044	WP_050330549.1	sensor histidine kinase	Regulator
MUA72_RS04335 (MUA72_04325)	vraR	956930..957559 (+)	630	WP_016425506.1	response regulator transcription factor	Regulator
MUA72_RS04340 (MUA72_04330)	-	957614..958186 (-)	573	WP_016425505.1	carbonic anhydrase	-
MUA72_RS04345 (MUA72_04335)	-	958219..959478 (-)	1260	WP_016425504.1	YihY/virulence factor BrkB family protein	-
MUA72_RS04350 (MUA72_04340)	-	959769..960056 (-)	288	WP_016425503.1	YtxH domain-containing protein	-
MUA72_RS04355 (MUA72_04345)	-	960064..960522 (-)	459	WP_016425502.1	low molecular weight protein-tyrosine-phosphatase	-
MUA72_RS04360 (MUA72_04350)	-	960655..960858 (+)	204	WP_016425501.1	DUF1128 family protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40139.47 Da
• Isoelectric Point: 5.4523

>NTDB_id=671023 MUA72_RS04330 WP_050330549.1 955897..956940(+) (vraS) [Staphylococcus schleiferi strain IVB6176]
MNHYVRAIGSMLILVYSMFTAFFFIDKVFTNIIYFQGMFYTQIFGIPVFIFLNLIVIFLCIIVGSVLAYKINQQNDWLKQ
QIERAFEGETVGINDQHIELYNETIELYQALVPLNQELHKMRIKTQNLTNESYNMNDLKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETELTPPLDQQIPTLEKMVQDSQLEMRALLLHLRPIGLKDRSLGEGIKSLVTDLQRKVPMKVVQEI
DEFEVPKGIEDHLFRITQEAISNTLRHAKGKQVTVELLNREDYLLLRIQDDGIGFNVDDKLEQSYGLKNMRERAIEIGAT
FHIVSLPDAGTRIEVKAPLDKEVHNDN

Nucleotide

• Length: 1044 bp

>NTDB_id=671023 MUA72_RS04330 WP_050330549.1 955897..956940(+) (vraS) [Staphylococcus schleiferi strain IVB6176]
ATGAACCATTACGTTCGTGCCATAGGCTCAATGTTGATTTTAGTCTACAGTATGTTTACTGCTTTTTTCTTTATTGATAA
AGTCTTTACTAATATCATTTATTTTCAAGGCATGTTTTATACCCAGATTTTTGGGATTCCCGTATTTATCTTTTTAAATT
TAATCGTTATCTTTCTTTGTATCATTGTAGGTAGCGTACTTGCCTATAAAATCAATCAACAAAATGATTGGTTGAAGCAA
CAAATTGAACGTGCATTTGAAGGGGAAACAGTAGGGATCAATGACCAACATATCGAATTATATAATGAGACGATTGAACT
GTATCAAGCCCTTGTTCCTTTGAATCAAGAACTTCATAAAATGCGTATTAAAACTCAAAATTTAACGAACGAATCTTATA
ATATGAACGATTTGAAAGTGAAAAAAATAATTGAAGATGAGAGACAACGGTTGGCTAGGGAATTACACGATAGTGTGTCC
CAACAACTCTTTGCGGCAAGCATGATGTTATCCGCGATTAAAGAAACAGAGTTAACCCCACCACTCGATCAGCAAATTCC
AACTTTAGAGAAAATGGTCCAAGATTCTCAGTTGGAGATGCGGGCGTTATTGTTACATTTGAGACCGATAGGACTTAAAG
ACCGCTCGTTAGGTGAAGGTATTAAATCATTAGTTACAGATCTACAAAGAAAAGTTCCAATGAAAGTTGTACAAGAAATT
GACGAATTTGAAGTGCCAAAAGGGATAGAAGACCACTTATTTCGAATCACTCAAGAAGCCATCTCTAATACATTACGTCA
TGCTAAAGGGAAACAAGTTACTGTCGAATTGCTCAATCGTGAAGACTATTTATTGTTGCGTATTCAAGATGACGGTATCG
GTTTTAATGTAGATGACAAATTAGAGCAAAGTTATGGACTTAAAAATATGCGTGAACGTGCAATAGAAATCGGGGCAACC
TTTCATATCGTTTCATTGCCAGACGCTGGGACGAGAATAGAAGTAAAGGCACCACTTGATAAGGAGGTACATAATGACAA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase (HisKA_3) (147-210)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

3D structure

• AlphaFold DB: A0A0K1ACB9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	84.438	100	0.844