Detailed information NTG0662496

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MNU33_RS04545
• Genome accession: NZ_CP093208
• Coordinates: 960087..961133 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain TSM-47
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 955087..966133

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MNU33_RS04520 (MNU33_04515)	-	956228..956764 (+)	537	WP_001830372.1	hypothetical protein	-
MNU33_RS04525 (MNU33_04520)	-	956915..957901 (-)	987	WP_001830388.1	aromatic acid exporter family protein	-
MNU33_RS04530 (MNU33_04525)	map	958075..958830 (+)	756	WP_001830397.1	type I methionyl aminopeptidase	-
MNU33_RS04535 (MNU33_04530)	-	958988..959374 (+)	387	WP_001830382.1	hypothetical protein	-
MNU33_RS04540 (MNU33_04535)	liaF	959389..960090 (+)	702	WP_001830436.1	cell wall-active antibiotics response protein LiaF	-
MNU33_RS04545 (MNU33_04540)	vraS	960087..961133 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
MNU33_RS04550 (MNU33_04545)	vraR	961123..961752 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
MNU33_RS04555 (MNU33_04550)	-	961809..962987 (-)	1179	WP_021298785.1	YihY/virulence factor BrkB family protein	-
MNU33_RS04560 (MNU33_04555)	-	963394..963678 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
MNU33_RS04565 (MNU33_04560)	-	963686..964150 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
MNU33_RS04570 (MNU33_04565)	-	964291..964506 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
MNU33_RS04575 (MNU33_04570)	-	964508..965749 (+)	1242	WP_001832467.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=662496 MNU33_RS04545 WP_001830374.1 960087..961133(+) (vraS) [Staphylococcus epidermidis strain TSM-47]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=662496 MNU33_RS04545 WP_001830374.1 960087..961133(+) (vraS) [Staphylococcus epidermidis strain TSM-47]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92