Detailed information
Bioinformatically predicted
Overview
| Name | ccrB | Type | Machinery gene |
| Locus tag | MNU31_RS00280 | Genome accession | NZ_CP093179 |
| Coordinates | 60974..62602 (-) | Length | 542 a.a. |
| NCBI ID | WP_001186596.1 | Uniprot ID | - |
| Organism | Staphylococcus epidermidis strain TMDU-190 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 42811..115065 | 60974..62602 | within | 0 |
Gene organization within MGE regions
Location: 42811..115065
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MNU31_RS00185 (MNU31_00185) | mecA | 42811..44820 (-) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| MNU31_RS00190 (MNU31_00190) | mecR1 | 44917..46674 (+) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| MNU31_RS00195 (MNU31_00195) | mecI | 46674..47045 (+) | 372 | WP_000369214.1 | mecA-type methicillin resistance repressor MecI | - |
| MNU31_RS00200 (MNU31_00200) | psm-mec | 47130..47198 (-) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| MNU31_RS00205 (MNU31_00205) | - | 47532..48662 (+) | 1131 | WP_010922808.1 | ROK family transcriptional regulator | - |
| MNU31_RS00210 (MNU31_00210) | cstB | 48776..50110 (-) | 1335 | Protein_39 | persulfide dioxygenase-sulfurtransferase CstB | - |
| MNU31_RS00215 (MNU31_00215) | - | 50143..51207 (-) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| MNU31_RS00220 (MNU31_00220) | cstR | 51343..51603 (+) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| MNU31_RS00225 (MNU31_00225) | - | 51603..52241 (+) | 639 | Protein_42 | sulfite exporter TauE/SafE family protein | - |
| MNU31_RS00230 (MNU31_00235) | - | 52515..53131 (-) | 617 | Protein_43 | CadD family cadmium resistance transporter | - |
| MNU31_RS00235 (MNU31_00240) | - | 53212..55626 (-) | 2415 | WP_000378485.1 | cadmium-translocating P-type ATPase CadA | - |
| MNU31_RS00240 (MNU31_00245) | - | 55619..55984 (-) | 366 | WP_000159127.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| MNU31_RS00245 (MNU31_00250) | - | 56222..56599 (-) | 378 | WP_001041908.1 | DUF6262 family protein | - |
| MNU31_RS00250 (MNU31_00255) | - | 56606..58498 (-) | 1893 | WP_002485298.1 | site-specific integrase | - |
| MNU31_RS00255 (MNU31_00260) | - | 58693..59016 (-) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| MNU31_RS00260 (MNU31_00265) | - | 59009..59215 (-) | 207 | WP_001077283.1 | hypothetical protein | - |
| MNU31_RS00265 (MNU31_00270) | - | 59217..59738 (-) | 522 | WP_000836008.1 | DUF1643 domain-containing protein | - |
| MNU31_RS00270 (MNU31_00275) | - | 59757..60068 (-) | 312 | WP_000833212.1 | DUF960 family protein | - |
| MNU31_RS00275 (MNU31_00280) | - | 60153..60503 (-) | 351 | WP_000171449.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| MNU31_RS00280 (MNU31_00285) | ccrB | 60974..62602 (-) | 1629 | WP_001186596.1 | recombinase family protein | Machinery gene |
| MNU31_RS00285 (MNU31_00290) | ccrA | 62623..63969 (-) | 1347 | WP_000816499.1 | recombinase family protein | Machinery gene |
| MNU31_RS00290 (MNU31_00295) | - | 64162..64437 (-) | 276 | WP_001791132.1 | hypothetical protein | - |
| MNU31_RS00295 (MNU31_00300) | - | 64527..66314 (-) | 1788 | WP_000181743.1 | DUF927 domain-containing protein | - |
| MNU31_RS00300 (MNU31_00305) | - | 66314..66598 (-) | 285 | WP_000659554.1 | DUF1413 domain-containing protein | - |
| MNU31_RS00305 (MNU31_00310) | - | 66736..67784 (+) | 1049 | Protein_58 | ACP synthase | - |
| MNU31_RS00310 (MNU31_00315) | - | 67837..68409 (+) | 573 | WP_000489177.1 | ADP-ribosyltransferase | - |
| MNU31_RS00315 (MNU31_00320) | - | 68741..69067 (+) | 327 | WP_000624048.1 | helix-turn-helix domain-containing protein | - |
| MNU31_RS00320 (MNU31_00325) | - | 69104..69937 (+) | 834 | WP_000694291.1 | CPBP family intramembrane glutamic endopeptidase | - |
| MNU31_RS00325 (MNU31_00330) | - | 70142..70306 (+) | 165 | WP_001028954.1 | hypothetical protein | - |
| MNU31_RS00330 (MNU31_00335) | - | 70623..71258 (+) | 636 | WP_254104805.1 | hypothetical protein | - |
| MNU31_RS00335 (MNU31_00340) | - | 71344..72516 (+) | 1173 | WP_000195429.1 | IS256-like element IS256 family transposase | - |
| MNU31_RS00340 (MNU31_00345) | - | 72561..72728 (+) | 168 | WP_254104807.1 | hypothetical protein | - |
| MNU31_RS00345 (MNU31_00350) | - | 72966..73325 (-) | 360 | WP_000432280.1 | DUF4870 domain-containing protein | - |
| MNU31_RS00350 (MNU31_00355) | - | 73490..74560 (-) | 1071 | WP_001054882.1 | nitronate monooxygenase family protein | - |
| MNU31_RS00355 (MNU31_00360) | - | 74573..75439 (-) | 867 | WP_001052247.1 | LysR family transcriptional regulator | - |
| MNU31_RS00360 (MNU31_00365) | - | 75426..76616 (-) | 1191 | WP_000716034.1 | YbfB/YjiJ family MFS transporter | - |
| MNU31_RS00365 (MNU31_00370) | - | 76827..77501 (+) | 675 | Protein_70 | IS6 family transposase | - |
| MNU31_RS00370 (MNU31_00375) | - | 77561..77989 (-) | 429 | WP_000671997.1 | VOC family protein | - |
| MNU31_RS00375 (MNU31_00380) | - | 78070..78999 (+) | 930 | WP_002504713.1 | HTH domain-containing protein | - |
| MNU31_RS00380 (MNU31_00385) | - | 79161..80240 (+) | 1080 | Protein_73 | hypothetical protein | - |
| MNU31_RS00385 (MNU31_00390) | - | 80297..80971 (+) | 675 | WP_002487846.1 | IS6-like element IS257 family transposase | - |
| MNU31_RS00390 (MNU31_00395) | - | 81037..81231 (-) | 195 | WP_000261373.1 | hypothetical protein | - |
| MNU31_RS00395 (MNU31_00400) | - | 81343..81600 (-) | 258 | WP_001802814.1 | hypothetical protein | - |
| MNU31_RS00400 (MNU31_00405) | - | 81788..82303 (+) | 516 | WP_000377077.1 | hypothetical protein | - |
| MNU31_RS00405 (MNU31_00410) | merB | 82498..83148 (-) | 651 | WP_000790334.1 | organomercurial lyase MerB | - |
| MNU31_RS00410 (MNU31_00415) | merA | 83230..84873 (-) | 1644 | WP_000193219.1 | mercury(II) reductase | - |
| MNU31_RS00415 (MNU31_00420) | - | 84931..85269 (-) | 339 | WP_000968575.1 | hypothetical protein | - |
| MNU31_RS00420 (MNU31_00425) | - | 85404..86084 (-) | 681 | WP_000010351.1 | cytochrome c biogenesis CcdA family protein | - |
| MNU31_RS00425 (MNU31_00430) | - | 86081..86434 (-) | 354 | WP_000746201.1 | TlpA disulfide reductase family protein | - |
| MNU31_RS00430 (MNU31_00435) | merR | 86451..86858 (-) | 408 | WP_000425271.1 | Hg(II)-responsive transcriptional regulator MerR | - |
| MNU31_RS00435 (MNU31_00440) | - | 87158..88504 (-) | 1347 | WP_000163428.1 | NAD(P)/FAD-dependent oxidoreductase | - |
| MNU31_RS00440 (MNU31_00445) | - | 88787..89461 (+) | 675 | WP_001105999.1 | IS6-like element IS257 family transposase | - |
| MNU31_RS00445 (MNU31_00450) | - | 89491..89805 (+) | 315 | Protein_86 | MFS transporter | - |
| MNU31_RS00450 (MNU31_00455) | - | 90345..90737 (+) | 393 | Protein_87 | hydroxyacid dehydrogenase | - |
| MNU31_RS00455 (MNU31_00460) | - | 90973..92391 (+) | 1419 | WP_002498810.1 | aspartate aminotransferase family protein | - |
| MNU31_RS00460 (MNU31_00465) | - | 92476..92748 (-) | 273 | Protein_89 | hypothetical protein | - |
| MNU31_RS00465 (MNU31_00470) | - | 92761..93981 (-) | 1221 | WP_032601843.1 | hypothetical protein | - |
| MNU31_RS00470 (MNU31_00475) | - | 93981..94793 (-) | 813 | WP_002504699.1 | abortive infection system antitoxin AbiGi family protein | - |
| MNU31_RS00475 (MNU31_00480) | - | 94984..96498 (+) | 1515 | WP_002504700.1 | class I SAM-dependent DNA methyltransferase | - |
| MNU31_RS00480 (MNU31_00485) | - | 96488..97762 (+) | 1275 | WP_002504701.1 | restriction endonuclease subunit S | - |
| MNU31_RS00485 (MNU31_00490) | - | 97746..100865 (+) | 3120 | WP_002504702.1 | type I restriction endonuclease subunit R | - |
| MNU31_RS00490 (MNU31_00495) | - | 100943..101266 (-) | 324 | WP_001176049.1 | PepSY domain-containing protein | - |
| MNU31_RS00495 (MNU31_00500) | - | 101660..101881 (-) | 222 | WP_002504703.1 | hypothetical protein | - |
| MNU31_RS00500 (MNU31_00505) | - | 101830..102273 (-) | 444 | WP_000941333.1 | hypothetical protein | - |
| MNU31_RS00505 (MNU31_00510) | - | 102335..102862 (-) | 528 | WP_002504704.1 | hypothetical protein | - |
| MNU31_RS00510 (MNU31_00515) | - | 102997..103485 (-) | 489 | WP_000393586.1 | hypothetical protein | - |
| MNU31_RS00515 (MNU31_00520) | - | 103501..103791 (-) | 291 | WP_000065261.1 | hypothetical protein | - |
| MNU31_RS00520 (MNU31_00525) | - | 103848..104720 (-) | 873 | WP_000373149.1 | HTH domain-containing protein | - |
| MNU31_RS13365 | - | 104890..105039 (-) | 150 | Protein_102 | JAB domain-containing protein | - |
| MNU31_RS00530 (MNU31_00535) | - | 105268..105930 (-) | 663 | WP_001092058.1 | class I SAM-dependent methyltransferase | - |
| MNU31_RS13405 | - | 106322..106381 (+) | 60 | WP_010959190.1 | erythromycin resistance leader peptide | - |
| MNU31_RS00535 (MNU31_00540) | erm(A) | 106489..107220 (+) | 732 | WP_254104725.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) | - |
| MNU31_RS00540 (MNU31_00545) | - | 107346..108128 (-) | 783 | WP_000067268.1 | aminoglycoside nucleotidyltransferase ANT(9)-Ia | - |
| MNU31_RS00545 (MNU31_00550) | - | 108279..108656 (-) | 378 | WP_000361059.1 | DUF6262 family protein | - |
| MNU31_RS00550 (MNU31_00555) | - | 108663..110555 (-) | 1893 | WP_254104727.1 | site-specific integrase | - |
| MNU31_RS00555 (MNU31_00560) | - | 110552..111637 (-) | 1086 | WP_000868132.1 | tyrosine-type recombinase/integrase | - |
| MNU31_RS00560 (MNU31_00565) | - | 111678..111995 (-) | 318 | WP_130825069.1 | JAB domain-containing protein | - |
| MNU31_RS00565 (MNU31_00570) | - | 112016..112522 (-) | 507 | WP_000849085.1 | DUF1643 domain-containing protein | - |
| MNU31_RS00570 (MNU31_00575) | - | 112538..112849 (-) | 312 | WP_001083108.1 | DUF960 family protein | - |
| MNU31_RS00575 (MNU31_00580) | - | 112945..113283 (-) | 339 | WP_000171557.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| MNU31_RS00580 (MNU31_00585) | - | 113389..115065 (-) | 1677 | WP_002504707.1 | recombinase family protein | - |
Sequence
Protein
Download Length: 542 a.a. Molecular weight: 62274.15 Da Isoelectric Point: 9.7334
>NTDB_id=662161 MNU31_RS00280 WP_001186596.1 60974..62602(-) (ccrB) [Staphylococcus epidermidis strain TMDU-190]
MQQLKQKRVGIYVRVSTEIQSTEGYSIDGQINQIREYCDFNNFVVVDVYADRGISGKSMNRPELQRLLKDANEGQIDSVM
VYKTNRLARNTSDLLKIVEDLHRQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPDSKHELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGKPFSIGSVTYILSNPFYVGKIQFAK
YKDWNEKRRKGLNDKPIIAEGKHSPIIIQDLWDKVQLRKKQVSQKPQVHGKGTNLLTGIVHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEKYVMDQILEIVKSDKVINQVLERVNQENKVDIGALNHDIAYKQQQYD
EVSGKLHNLVKTIEDNPDLTSALKATIHQYETQLNDITNQMNQLKQQQNQEKLSYDTKQIAALLQRIFQNIESMDKAQLK
ALYLTVIDRIDIRKDGNHKKQFYVTLKLNNEIIKQLFNNTPLDEVLLSTSSLFLPQTLFLQI
MQQLKQKRVGIYVRVSTEIQSTEGYSIDGQINQIREYCDFNNFVVVDVYADRGISGKSMNRPELQRLLKDANEGQIDSVM
VYKTNRLARNTSDLLKIVEDLHRQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPDSKHELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGKPFSIGSVTYILSNPFYVGKIQFAK
YKDWNEKRRKGLNDKPIIAEGKHSPIIIQDLWDKVQLRKKQVSQKPQVHGKGTNLLTGIVHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEKYVMDQILEIVKSDKVINQVLERVNQENKVDIGALNHDIAYKQQQYD
EVSGKLHNLVKTIEDNPDLTSALKATIHQYETQLNDITNQMNQLKQQQNQEKLSYDTKQIAALLQRIFQNIESMDKAQLK
ALYLTVIDRIDIRKDGNHKKQFYVTLKLNNEIIKQLFNNTPLDEVLLSTSSLFLPQTLFLQI
Nucleotide
Download Length: 1629 bp
>NTDB_id=662161 MNU31_RS00280 WP_001186596.1 60974..62602(-) (ccrB) [Staphylococcus epidermidis strain TMDU-190]
ATGCAACAACTCAAACAAAAACGTGTCGGTATCTATGTTCGTGTATCAACGGAAATCCAAAGTACTGAAGGCTATAGTAT
CGATGGACAAATCAATCAAATTCGAGAATATTGTGATTTCAATAACTTTGTTGTTGTAGATGTATACGCGGATAGAGGTA
TCTCTGGAAAATCTATGAACCGACCAGAACTACAACGTTTGTTAAAAGATGCGAACGAAGGTCAGATTGATTCTGTTATG
GTCTACAAAACAAACCGACTAGCACGTAACACTTCTGACTTACTCAAAATTGTTGAAGACCTTCATCGTCAAAATGTCGA
ATTCTTCAGCTTATCTGAGCGTATGGAAGTCAATACAAGCAGTGGTAAATTGATGCTACAAATTCTAGCGAGTTTTTCAG
AATTTGAAAGAAATAATATTGTCGAAAATGTATTCATGGGTCAAACCCGACGCGCTCAAGAAGGCTATTATCAAGGCAAT
TTGCCGCTGGGCTATGACAAAATACCGGATAGCAAGCATGAACTCATGATAAACCAACATGAAGCGAATATTGTCAAATA
TATATTTGAGTCATATGCTAAAGGCCACGGATATCGTAAAATTGCGAATGCACTCAATCACAAAGGATACGTGACTAAAA
AAGGAAAGCCTTTCAGTATTGGTTCAGTGACCTATATCTTATCTAATCCATTCTATGTTGGTAAAATTCAATTCGCAAAG
TACAAAGATTGGAATGAAAAGCGTCGTAAAGGGCTGAATGATAAACCAATAATAGCTGAAGGTAAGCATTCCCCTATTAT
TATTCAAGACTTATGGGATAAAGTCCAATTACGTAAAAAACAAGTCAGTCAAAAACCTCAAGTCCACGGTAAAGGAACTA
ATCTATTAACAGGTATCGTTCATTGTCCACAATGTGGTGCACCAATGGCAGCTAGTAACACAACGAACACATTGAAAGAT
GGTACCAAGAAGCGAATACGTTATTATTCTTGCAGTAACTTCCGAAACAAAGGCTCAAAAGTATGTTCTGCGAATAGCGT
TAGAGCTGATGTGATTGAGAAATACGTCATGGATCAAATACTCGAAATTGTCAAAAGTGATAAAGTCATTAACCAAGTCT
TAGAACGTGTCAATCAAGAAAATAAAGTCGATATTGGTGCATTGAACCACGATATCGCTTATAAACAACAACAATACGAT
GAAGTCAGCGGGAAACTCCATAATTTAGTTAAAACCATTGAAGATAATCCGGACCTAACATCTGCATTGAAAGCAACTAT
TCATCAATATGAAACACAACTCAATGACATTACAAATCAAATGAATCAACTCAAACAGCAACAAAATCAAGAGAAACTAT
CTTATGATACGAAACAAATCGCTGCCCTATTACAACGAATATTTCAAAATATAGAATCAATGGATAAAGCACAACTCAAA
GCATTATATCTTACAGTCATTGACCGTATTGATATTCGTAAAGACGGTAATCATAAAAAACAGTTCTACGTTACACTAAA
ACTCAATAATGAAATTATTAAACAACTTTTCAATAATACCCCTCTCGACGAAGTGCTCCTCAGCACTTCGTCTTTATTTT
TGCCTCAAACGCTCTTTCTTCAAATCTAA
ATGCAACAACTCAAACAAAAACGTGTCGGTATCTATGTTCGTGTATCAACGGAAATCCAAAGTACTGAAGGCTATAGTAT
CGATGGACAAATCAATCAAATTCGAGAATATTGTGATTTCAATAACTTTGTTGTTGTAGATGTATACGCGGATAGAGGTA
TCTCTGGAAAATCTATGAACCGACCAGAACTACAACGTTTGTTAAAAGATGCGAACGAAGGTCAGATTGATTCTGTTATG
GTCTACAAAACAAACCGACTAGCACGTAACACTTCTGACTTACTCAAAATTGTTGAAGACCTTCATCGTCAAAATGTCGA
ATTCTTCAGCTTATCTGAGCGTATGGAAGTCAATACAAGCAGTGGTAAATTGATGCTACAAATTCTAGCGAGTTTTTCAG
AATTTGAAAGAAATAATATTGTCGAAAATGTATTCATGGGTCAAACCCGACGCGCTCAAGAAGGCTATTATCAAGGCAAT
TTGCCGCTGGGCTATGACAAAATACCGGATAGCAAGCATGAACTCATGATAAACCAACATGAAGCGAATATTGTCAAATA
TATATTTGAGTCATATGCTAAAGGCCACGGATATCGTAAAATTGCGAATGCACTCAATCACAAAGGATACGTGACTAAAA
AAGGAAAGCCTTTCAGTATTGGTTCAGTGACCTATATCTTATCTAATCCATTCTATGTTGGTAAAATTCAATTCGCAAAG
TACAAAGATTGGAATGAAAAGCGTCGTAAAGGGCTGAATGATAAACCAATAATAGCTGAAGGTAAGCATTCCCCTATTAT
TATTCAAGACTTATGGGATAAAGTCCAATTACGTAAAAAACAAGTCAGTCAAAAACCTCAAGTCCACGGTAAAGGAACTA
ATCTATTAACAGGTATCGTTCATTGTCCACAATGTGGTGCACCAATGGCAGCTAGTAACACAACGAACACATTGAAAGAT
GGTACCAAGAAGCGAATACGTTATTATTCTTGCAGTAACTTCCGAAACAAAGGCTCAAAAGTATGTTCTGCGAATAGCGT
TAGAGCTGATGTGATTGAGAAATACGTCATGGATCAAATACTCGAAATTGTCAAAAGTGATAAAGTCATTAACCAAGTCT
TAGAACGTGTCAATCAAGAAAATAAAGTCGATATTGGTGCATTGAACCACGATATCGCTTATAAACAACAACAATACGAT
GAAGTCAGCGGGAAACTCCATAATTTAGTTAAAACCATTGAAGATAATCCGGACCTAACATCTGCATTGAAAGCAACTAT
TCATCAATATGAAACACAACTCAATGACATTACAAATCAAATGAATCAACTCAAACAGCAACAAAATCAAGAGAAACTAT
CTTATGATACGAAACAAATCGCTGCCCTATTACAACGAATATTTCAAAATATAGAATCAATGGATAAAGCACAACTCAAA
GCATTATATCTTACAGTCATTGACCGTATTGATATTCGTAAAGACGGTAATCATAAAAAACAGTTCTACGTTACACTAAA
ACTCAATAATGAAATTATTAAACAACTTTTCAATAATACCCCTCTCGACGAAGTGCTCCTCAGCACTTCGTCTTTATTTT
TGCCTCAAACGCTCTTTCTTCAAATCTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrB | Staphylococcus aureus N315 |
86.531 |
100 |
0.865 |