Detailed information NTG0662135

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MNU44_RS04570
• Genome accession: NZ_CP093173
• Coordinates: 987243..988289 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain TMDU-137
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 982243..993289

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MNU44_RS04545 (MNU44_04540)	-	983384..983920 (+)	537	WP_001830372.1	hypothetical protein	-
MNU44_RS04550 (MNU44_04545)	-	984071..985057 (-)	987	WP_020368335.1	aromatic acid exporter family protein	-
MNU44_RS04555 (MNU44_04550)	map	985231..985986 (+)	756	WP_001830397.1	type I methionyl aminopeptidase	-
MNU44_RS04560 (MNU44_04555)	-	986144..986530 (+)	387	WP_001830382.1	hypothetical protein	-
MNU44_RS04565 (MNU44_04560)	liaF	986545..987246 (+)	702	WP_002457093.1	cell wall-active antibiotics response protein LiaF	-
MNU44_RS04570 (MNU44_04565)	vraS	987243..988289 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
MNU44_RS04575 (MNU44_04570)	vraR	988279..988908 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
MNU44_RS04580 (MNU44_04575)	-	988965..990143 (-)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
MNU44_RS04585 (MNU44_04580)	-	990550..990834 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
MNU44_RS04590 (MNU44_04585)	-	990842..991306 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
MNU44_RS04595 (MNU44_04590)	-	991447..991662 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
MNU44_RS04600 (MNU44_04595)	-	991664..992905 (+)	1242	WP_002457094.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=662135 MNU44_RS04570 WP_001830374.1 987243..988289(+) (vraS) [Staphylococcus epidermidis strain TMDU-137]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=662135 MNU44_RS04570 WP_001830374.1 987243..988289(+) (vraS) [Staphylococcus epidermidis strain TMDU-137]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GATTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92