Detailed information
Bioinformatically predicted
Overview
| Name | sigH | Type | Regulator |
| Locus tag | MAK06_RS02520 | Genome accession | NZ_CP091876 |
| Coordinates | 530053..530622 (+) | Length | 189 a.a. |
| NCBI ID | WP_000872873.1 | Uniprot ID | - |
| Organism | Staphylococcus aureus strain FRI-1169 | ||
| Function | promote expression of competence genes (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 526970..584173 | 530053..530622 | within | 0 |
Gene organization within MGE regions
Location: 526970..584173
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MAK06_RS02505 (MAK06_11355) | - | 528290..528694 (+) | 405 | WP_000370182.1 | Mini-ribonuclease 3 | - |
| MAK06_RS02510 (MAK06_11350) | rlmB | 528702..529448 (+) | 747 | WP_000390328.1 | 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB | - |
| MAK06_RS02515 (MAK06_11345) | - | 529448..529972 (+) | 525 | WP_000664738.1 | NYN domain-containing protein | - |
| MAK06_RS02520 (MAK06_11340) | sigH | 530053..530622 (+) | 570 | WP_000872873.1 | RNA polymerase sigma factor | Regulator |
| MAK06_RS02525 (MAK06_11335) | rpmG | 530737..530880 (+) | 144 | WP_001788193.1 | 50S ribosomal protein L33 | - |
| MAK06_RS02530 (MAK06_11330) | secE | 530936..531118 (+) | 183 | WP_001074474.1 | preprotein translocase subunit SecE | - |
| MAK06_RS02535 (MAK06_11325) | nusG | 531131..531679 (+) | 549 | WP_001288302.1 | transcription termination/antitermination protein NusG | - |
| MAK06_RS02540 (MAK06_11320) | rplK | 531860..532282 (+) | 423 | WP_001085792.1 | 50S ribosomal protein L11 | - |
| MAK06_RS02545 (MAK06_11315) | rplA | 532490..533182 (+) | 693 | WP_001074619.1 | 50S ribosomal protein L1 | - |
| MAK06_RS02550 (MAK06_11310) | rplJ | 533454..533954 (+) | 501 | WP_001273085.1 | 50S ribosomal protein L10 | - |
| MAK06_RS02555 (MAK06_11305) | rplL | 533997..534365 (+) | 369 | WP_001273586.1 | 50S ribosomal protein L7/L12 | - |
| MAK06_RS02560 (MAK06_11300) | - | 534540..535148 (+) | 609 | WP_000020304.1 | class I SAM-dependent methyltransferase | - |
| MAK06_RS02565 (MAK06_11295) | rpoB | 535363..538914 (+) | 3552 | WP_000918667.1 | DNA-directed RNA polymerase subunit beta | - |
| MAK06_RS02570 (MAK06_11290) | rpoC | 539078..542674 (+) | 3597 | WP_001788197.1 | DNA-directed RNA polymerase subunit beta' | - |
| MAK06_RS02575 (MAK06_11285) | - | 542811..543065 (+) | 255 | WP_000031892.1 | ribosomal L7Ae/L30e/S12e/Gadd45 family protein | - |
| MAK06_RS02580 (MAK06_11280) | rpsL | 543163..543576 (+) | 414 | WP_001142337.1 | 30S ribosomal protein S12 | - |
| MAK06_RS02585 (MAK06_11275) | rpsG | 543642..544112 (+) | 471 | WP_001137495.1 | 30S ribosomal protein S7 | - |
| MAK06_RS02590 (MAK06_11270) | fusA | 544235..546316 (+) | 2082 | WP_000090315.1 | elongation factor G | - |
| MAK06_RS02595 (MAK06_11265) | tuf | 546533..547717 (+) | 1185 | WP_001040568.1 | elongation factor Tu | - |
| MAK06_RS02600 (MAK06_11260) | - | 547999..549174 (-) | 1176 | WP_000887915.1 | M20 family metallopeptidase | - |
| MAK06_RS02605 (MAK06_11255) | - | 549345..550532 (+) | 1188 | WP_000250824.1 | glycine C-acetyltransferase | - |
| MAK06_RS02610 (MAK06_11250) | hchA | 550798..551676 (+) | 879 | WP_000076404.1 | glyoxalase III HchA | - |
| MAK06_RS02615 (MAK06_11245) | - | 551836..553473 (+) | 1638 | WP_000122340.1 | ribulokinase | - |
| MAK06_RS02620 (MAK06_11240) | - | 553687..554652 (+) | 966 | WP_000723301.1 | NAD-dependent epimerase/dehydratase family protein | - |
| MAK06_RS02625 (MAK06_11235) | - | 554987..556063 (+) | 1077 | WP_000076036.1 | branched-chain amino acid aminotransferase | - |
| MAK06_RS02630 (MAK06_11230) | - | 556313..556996 (+) | 684 | WP_000454784.1 | HAD family hydrolase | - |
| MAK06_RS02635 (MAK06_11225) | - | 557112..557774 (-) | 663 | WP_001067262.1 | deoxynucleoside kinase | - |
| MAK06_RS02640 (MAK06_11220) | - | 557767..558384 (-) | 618 | WP_001039519.1 | deoxynucleoside kinase | - |
| MAK06_RS02645 (MAK06_11215) | tadA | 558451..558921 (+) | 471 | WP_000180281.1 | tRNA adenosine(34) deaminase TadA | - |
| MAK06_RS02650 (MAK06_11210) | - | 559068..559937 (+) | 870 | WP_000593367.1 | Cof-type HAD-IIB family hydrolase | - |
| MAK06_RS02655 (MAK06_11205) | - | 559958..560524 (+) | 567 | WP_000677261.1 | NADPH-dependent FMN reductase | - |
| MAK06_RS02660 (MAK06_11200) | sdrC | 560954..563791 (+) | 2838 | WP_238097423.1 | MSCRAMM family adhesin SdrC | - |
| MAK06_RS02665 (MAK06_11195) | sdrD | 564158..568285 (+) | 4128 | WP_000934423.1 | MSCRAMM family adhesin SdrD | - |
| MAK06_RS02670 (MAK06_11190) | sdrE | 568679..572143 (+) | 3465 | WP_053862567.1 | MSCRAMM family adhesin SdrE | - |
| MAK06_RS02675 (MAK06_11185) | - | 572263..573735 (+) | 1473 | WP_001106738.1 | glycosyltransferase | - |
| MAK06_RS02680 (MAK06_11180) | - | 573859..575349 (-) | 1491 | WP_001106113.1 | glycosyltransferase | - |
| MAK06_RS02685 (MAK06_11175) | folE2 | 575631..576509 (-) | 879 | WP_000134232.1 | GTP cyclohydrolase FolE2 | - |
| MAK06_RS02690 (MAK06_11170) | bshB2 | 576522..577187 (-) | 666 | WP_000129063.1 | bacillithiol biosynthesis deacetylase BshB2 | - |
| MAK06_RS02695 (MAK06_11165) | - | 577201..577563 (-) | 363 | WP_001547756.1 | YojF family protein | - |
| MAK06_RS02700 (MAK06_11160) | nagB | 577839..578597 (+) | 759 | WP_000866415.1 | glucosamine-6-phosphate deaminase | - |
| MAK06_RS02705 (MAK06_11155) | hxlA | 578674..579306 (+) | 633 | WP_000422861.1 | 3-hexulose-6-phosphate synthase | - |
| MAK06_RS02710 (MAK06_11150) | hxlB | 579308..579856 (+) | 549 | WP_001051594.1 | 6-phospho-3-hexuloisomerase | - |
| MAK06_RS02715 (MAK06_11145) | - | 579969..580616 (+) | 648 | WP_000667097.1 | HAD family hydrolase | - |
| MAK06_RS02720 (MAK06_11140) | - | 581118..582518 (+) | 1401 | WP_000347061.1 | MFS transporter | - |
Sequence
Protein
Download Length: 189 a.a. Molecular weight: 23028.91 Da Isoelectric Point: 9.4170
>NTDB_id=654118 MAK06_RS02520 WP_000872873.1 530053..530622(+) (sigH) [Staphylococcus aureus strain FRI-1169]
MKYDLTTQDSTIKRNNAINDKDFEKLVMDLQPLIIRRIKTFGFNHYDLEDLYQEILIRMYRSVQTFDFSGEQPFTNYVQC
LITSVKYDYLRKYLATNKRMDNLINEYRVTYPCAIKRFDVENNYLNKLAIKELICQFKYLSAFEKDVMYLMCEQYKPREI
AQLMHVKEKVIYNAIQRCKNKIKRYFKMI
MKYDLTTQDSTIKRNNAINDKDFEKLVMDLQPLIIRRIKTFGFNHYDLEDLYQEILIRMYRSVQTFDFSGEQPFTNYVQC
LITSVKYDYLRKYLATNKRMDNLINEYRVTYPCAIKRFDVENNYLNKLAIKELICQFKYLSAFEKDVMYLMCEQYKPREI
AQLMHVKEKVIYNAIQRCKNKIKRYFKMI
Nucleotide
Download Length: 570 bp
>NTDB_id=654118 MAK06_RS02520 WP_000872873.1 530053..530622(+) (sigH) [Staphylococcus aureus strain FRI-1169]
TTGAAATACGATTTGACAACTCAAGACAGTACAATCAAACGTAACAATGCAATAAATGATAAAGACTTCGAAAAGTTAGT
AATGGATCTACAACCATTAATTATTCGACGCATCAAAACATTTGGATTTAATCATTATGATTTAGAAGACTTATATCAAG
AAATACTTATACGGATGTATAGGTCGGTCCAAACATTTGATTTTAGTGGAGAGCAGCCTTTCACAAATTATGTTCAATGT
TTAATTACGTCTGTAAAGTATGATTATTTGAGAAAATATTTAGCTACAAATAAAAGAATGGATAATTTGATTAATGAATA
TAGAGTTACGTATCCATGTGCAATAAAGCGTTTTGATGTTGAAAACAATTATTTGAATAAATTAGCAATTAAAGAGTTGA
TTTGTCAGTTTAAGTATTTGAGTGCATTTGAAAAAGATGTCATGTATTTAATGTGTGAACAATATAAGCCGAGAGAAATT
GCTCAATTGATGCATGTAAAAGAGAAAGTGATTTATAATGCCATACAACGATGTAAAAATAAAATAAAACGTTATTTCAA
AATGATTTGA
TTGAAATACGATTTGACAACTCAAGACAGTACAATCAAACGTAACAATGCAATAAATGATAAAGACTTCGAAAAGTTAGT
AATGGATCTACAACCATTAATTATTCGACGCATCAAAACATTTGGATTTAATCATTATGATTTAGAAGACTTATATCAAG
AAATACTTATACGGATGTATAGGTCGGTCCAAACATTTGATTTTAGTGGAGAGCAGCCTTTCACAAATTATGTTCAATGT
TTAATTACGTCTGTAAAGTATGATTATTTGAGAAAATATTTAGCTACAAATAAAAGAATGGATAATTTGATTAATGAATA
TAGAGTTACGTATCCATGTGCAATAAAGCGTTTTGATGTTGAAAACAATTATTTGAATAAATTAGCAATTAAAGAGTTGA
TTTGTCAGTTTAAGTATTTGAGTGCATTTGAAAAAGATGTCATGTATTTAATGTGTGAACAATATAAGCCGAGAGAAATT
GCTCAATTGATGCATGTAAAAGAGAAAGTGATTTATAATGCCATACAACGATGTAAAAATAAAATAAAACGTTATTTCAA
AATGATTTGA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| sigH | Staphylococcus aureus N315 |
99.471 |
100 |
0.995 |
| sigH | Staphylococcus aureus MW2 |
98.413 |
100 |
0.984 |