Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | L4X60_RS10065 | Genome accession | NZ_CP091525 |
| Coordinates | 2035085..2036434 (+) | Length | 449 a.a. |
| NCBI ID | WP_000815646.1 | Uniprot ID | Q9XB96 |
| Organism | Staphylococcus aureus strain N09CSA16 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 2030895..2065086 | 2035085..2036434 | within | 0 |
| SCCmec | 2035085..2056450 | 2035085..2036434 | within | 0 |
Gene organization within MGE regions
Location: 2030895..2065086
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L4X60_RS10050 (L4X60_10050) | - | 2031523..2032569 (+) | 1047 | WP_001060127.1 | hypothetical protein | - |
| L4X60_RS10055 (L4X60_10055) | - | 2032762..2033058 (+) | 297 | WP_000273824.1 | cassette chromosome ssDNA-binding protein | - |
| L4X60_RS10060 (L4X60_10060) | - | 2033058..2034851 (+) | 1794 | WP_000195100.1 | cassette chromosome replicative helicase | - |
| L4X60_RS10065 (L4X60_10065) | ccrA | 2035085..2036434 (+) | 1350 | WP_000815646.1 | cassette chromosome recombinase CcrA | Machinery gene |
| L4X60_RS10070 (L4X60_10070) | ccrB | 2036456..2038084 (+) | 1629 | WP_001186602.1 | cassette chromosome recombinase CcrB | Machinery gene |
| L4X60_RS10075 (L4X60_10075) | - | 2038602..2038952 (+) | 351 | WP_000859155.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| L4X60_RS10080 (L4X60_10080) | - | 2039039..2039350 (+) | 312 | WP_000700853.1 | DUF960 family protein | - |
| L4X60_RS10085 (L4X60_10085) | - | 2039368..2039874 (+) | 507 | WP_001092169.1 | DUF1643 domain-containing protein | - |
| L4X60_RS10090 (L4X60_10090) | - | 2039895..2040212 (+) | 318 | WP_000659050.1 | JAB domain-containing protein | - |
| L4X60_RS10095 (L4X60_10095) | - | 2040331..2041416 (+) | 1086 | WP_000868132.1 | tyrosine-type recombinase/integrase | - |
| L4X60_RS10100 (L4X60_10100) | - | 2041413..2043305 (+) | 1893 | WP_001557544.1 | site-specific integrase | - |
| L4X60_RS10105 (L4X60_10105) | - | 2043312..2043689 (+) | 378 | WP_000361059.1 | DUF6262 family protein | - |
| L4X60_RS10110 (L4X60_10110) | - | 2043840..2044622 (+) | 783 | WP_000067268.1 | aminoglycoside nucleotidyltransferase ANT(9)-Ia | - |
| L4X60_RS10115 (L4X60_10115) | erm(A) | 2044748..2045479 (-) | 732 | WP_001072201.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) | - |
| L4X60_RS14650 | - | 2045562..2045621 (-) | 60 | WP_010959190.1 | erythromycin resistance leader peptide | - |
| L4X60_RS10120 (L4X60_10120) | - | 2046013..2046675 (+) | 663 | WP_001092058.1 | class I SAM-dependent methyltransferase | - |
| L4X60_RS10125 (L4X60_10130) | - | 2047020..2047658 (-) | 639 | Protein_1971 | sulfite exporter TauE/SafE family protein | - |
| L4X60_RS10130 (L4X60_10135) | cstR | 2047658..2047918 (-) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| L4X60_RS10135 (L4X60_10140) | - | 2048054..2049118 (+) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| L4X60_RS10140 (L4X60_10145) | cstB | 2049151..2050485 (+) | 1335 | Protein_1974 | persulfide dioxygenase-sulfurtransferase CstB | - |
| L4X60_RS10145 (L4X60_10150) | - | 2050599..2051708 (-) | 1110 | WP_000943131.1 | ROK family transcriptional regulator | - |
| L4X60_RS10150 (L4X60_10155) | psm-mec | 2052063..2052131 (+) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| L4X60_RS10155 (L4X60_10160) | mecI | 2052216..2052587 (-) | 372 | WP_000369214.1 | mecA-type methicillin resistance repressor MecI | - |
| L4X60_RS10160 (L4X60_10165) | mecR1 | 2052587..2054344 (-) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| L4X60_RS10165 (L4X60_10170) | mecA | 2054441..2056450 (+) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| L4X60_RS10170 (L4X60_10175) | - | 2056496..2056924 (-) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| L4X60_RS10175 (L4X60_10180) | - | 2057021..2057764 (-) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| L4X60_RS10180 (L4X60_10185) | - | 2058641..2059030 (-) | 390 | WP_020444595.1 | hydroxymethylglutaryl-CoA synthase | - |
| L4X60_RS10185 (L4X60_10190) | - | 2059066..2059740 (+) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| L4X60_RS10190 (L4X60_10195) | aadD1 | 2059933..2060703 (+) | 771 | WP_001795128.1 | aminoglycoside O-nucleotidyltransferase ANT(4')-Ia | - |
| L4X60_RS10195 (L4X60_10200) | bleO | 2060920..2061324 (+) | 405 | WP_001242578.1 | bleomycin binding protein | - |
| L4X60_RS10200 (L4X60_10205) | mobV | 2061831..2063093 (+) | 1263 | WP_000119405.1 | MobV family relaxase | - |
| L4X60_RS10205 (L4X60_10210) | - | 2063338..2064321 (+) | 984 | Protein_1987 | protein rep | - |
| L4X60_RS10210 (L4X60_10215) | - | 2064412..2065086 (+) | 675 | WP_112401343.1 | IS6-like element IS257 family transposase | - |
Sequence
Protein
Download Length: 449 a.a. Molecular weight: 52607.20 Da Isoelectric Point: 9.9585
>NTDB_id=652156 L4X60_RS10065 WP_000815646.1 2035085..2036434(+) (ccrA) [Staphylococcus aureus strain N09CSA16]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA
Nucleotide
Download Length: 1350 bp
>NTDB_id=652156 L4X60_RS10065 WP_000815646.1 2035085..2036434(+) (ccrA) [Staphylococcus aureus strain N09CSA16]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus N315 |
100 |
100 |
1 |
| ccrA | Staphylococcus aureus COL |
74.833 |
100 |
0.748 |