NTDB

Overview

Name	cclA/cilC	Type	Machinery gene
Locus tag	L1A14_RS08425	Genome accession	NZ_CP090883
Coordinates	1641867..1642526 (+)	Length	219 a.a.
NCBI ID	WP_000565024.1	Uniprot ID	A0A4J1XTA1
Organism	Streptococcus pneumoniae strain LE4448
Function	processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1636867..1647526

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
L1A14_RS08400 (L1A14_08400)	-	1637172..1637489 (-)	318	WP_001151646.1	PTS sugar transporter subunit IIB	-
L1A14_RS08405 (L1A14_08405)	-	1637504..1638400 (-)	897	WP_000825665.1	PEP phosphonomutase	-
L1A14_RS08410 (L1A14_08410)	-	1638403..1639665 (-)	1263	WP_000413345.1	PTS sugar transporter subunit IIC	-
L1A14_RS08415 (L1A14_08415)	-	1639945..1641123 (+)	1179	WP_000175878.1	ROK family transcriptional regulator	-
L1A14_RS08420 (L1A14_08420)	-	1641351..1641797 (-)	447	WP_000155412.1	GNAT family N-acetyltransferase	-
L1A14_RS08425 (L1A14_08425)	cclA/cilC	1641867..1642526 (+)	660	WP_000565024.1	A24 family peptidase	Machinery gene
L1A14_RS08430 (L1A14_08430)	-	1642578..1643729 (-)	1152	WP_000481758.1	XRE family transcriptional regulator	-
L1A14_RS08435 (L1A14_08435)	-	1643744..1644475 (-)	732	WP_000934017.1	hypothetical protein	-
L1A14_RS08440 (L1A14_08440)	-	1644704..1644805 (+)	102	Protein_1676	prepilin peptidase	-
L1A14_RS08445 (L1A14_08445)	trpA	1644777..1645553 (-)	777	WP_001127028.1	tryptophan synthase subunit alpha	-
L1A14_RS08450 (L1A14_08450)	trpB	1645546..1646769 (-)	1224	WP_000331297.1	tryptophan synthase subunit beta	-
L1A14_RS08455 (L1A14_08455)	-	1646747..1647346 (-)	600	WP_000169899.1	phosphoribosylanthranilate isomerase	-

Sequence

Protein

Download Length: 219 a.a. Molecular weight: 24951.16 Da Isoelectric Point: 8.2409

                                >NTDB_id=645696 L1A14_RS08425 WP_000565024.1 1641867..1642526(+) (cclA/cilC) [Streptococcus pneumoniae strain LE4448]

MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELVLG

LLFLLYSWKLLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFHLILITSSGWNLVMVSFLILGILAHFIDIRMGAGDFL

FLASCALVFSVTELLILIQFASATGILAFILQKKKERLPFVPFLLLATCLIIFGKLLLV

Nucleotide

Download Length: 660 bp

                                >NTDB_id=645696 L1A14_RS08425 WP_000565024.1 1641867..1642526(+) (cclA/cilC) [Streptococcus pneumoniae strain LE4448]

ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA

ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC

AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAATTAGTCTTAGGA

CTCCTCTTTCTGCTTTACTCTTGGAAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTGGGTAT

CTACGACTTTCACCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAACTTCCTCTGGCTGGA

ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGCGCAGGGGATTTCCTC

TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTTGCTTCTGCGACGGGTATCCT

GGCCTTTATCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG

GTAAGCTACTGCTTGTCTGA

Domains

Predicted by InterproScan.

Bacterial Peptidase A24 N-terminal domain (A24_N_bact)

(8-89)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A4J1XTA1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
cclA/cilC	Streptococcus pneumoniae TIGR4	96.804	100	0.968
cclA/cilC	Streptococcus pneumoniae Rx1	95.434	100	0.954
cclA/cilC	Streptococcus pneumoniae D39	95.434	100	0.954
cclA/cilC	Streptococcus pneumoniae R6	95.434	100	0.954
cclA/cilC	Streptococcus mitis SK321	91.324	100	0.913
cclA/cilC	Streptococcus mitis NCTC 12261	85.388	100	0.854

Detailed information NTG0645696