NTDB

Overview

Name	micA	Type	Regulator
Locus tag	L1A14_RS05860	Genome accession	NZ_CP090883
Coordinates	1150185..1150889 (-)	Length	234 a.a.
NCBI ID	WP_000722076.1	Uniprot ID	Q9S1K0
Organism	Streptococcus pneumoniae strain LE4448
Function	repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1145185..1155889

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
L1A14_RS05830 (L1A14_05830)	-	1145366..1146352 (+)	987	WP_000204733.1	L-lactate dehydrogenase	-
L1A14_RS05835 (L1A14_05835)	-	1146653..1147396 (-)	744	Protein_1151	ion channel	-
L1A14_RS05840 (L1A14_05840)	-	1147443..1147697 (-)	255	WP_001812387.1	type II toxin-antitoxin system RelE/ParE family toxin	-
L1A14_RS05845 (L1A14_05845)	-	1147699..1147941 (-)	243	WP_000208080.1	DUF6290 family protein	-
L1A14_RS05850 (L1A14_05850)	vicX	1148032..1148841 (-)	810	WP_001289493.1	MBL fold metallo-hydrolase	Regulator
L1A14_RS05855 (L1A14_05855)	micB	1148843..1150192 (-)	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	Regulator
L1A14_RS05860 (L1A14_05860)	micA	1150185..1150889 (-)	705	WP_000722076.1	response regulator YycF	Regulator
L1A14_RS05865 (L1A14_05865)	mutY	1150944..1152119 (-)	1176	WP_000886147.1	A/G-specific adenine glycosylase	-
L1A14_RS05870 (L1A14_05870)	-	1152448..1154118 (-)	1671	WP_000845287.1	formate--tetrahydrofolate ligase	-
L1A14_RS05875 (L1A14_05875)	coaB	1154348..1155037 (+)	690	WP_000699489.1	phosphopantothenate--cysteine ligase	-
L1A14_RS05880 (L1A14_05880)	coaC	1155049..1155600 (+)	552	WP_001284130.1	phosphopantothenoylcysteine decarboxylase	-

Sequence

Protein

Download Length: 234 a.a. Molecular weight: 26815.63 Da Isoelectric Point: 4.7164

                                >NTDB_id=645685 L1A14_RS05860 WP_000722076.1 1150185..1150889(-) (micA) [Streptococcus pneumoniae strain LE4448]

MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA

KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT

HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide

Download Length: 705 bp

                                >NTDB_id=645685 L1A14_RS05860 WP_000722076.1 1150185..1150889(-) (micA) [Streptococcus pneumoniae strain LE4448]

ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA

AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA

TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC

AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA

GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC

AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC

CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT

CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC

CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
PDB	1NXS
PDB	2A9O
PDB	2A9P

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
micA	Streptococcus pneumoniae Cp1015	100	100	1
vicR	Streptococcus mutans UA159	78.541	99.573	0.782
covR	Streptococcus salivarius strain HSISS4	44.156	98.718	0.436
covR	Lactococcus lactis subsp. lactis strain DGCC12653	43.478	98.291	0.427
scnR	Streptococcus mutans UA159	38.197	99.573	0.38

Detailed information NTG0645685