Detailed information NTG0645671

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: L1A14_RS02725
• Genome accession: NZ_CP090883
• Coordinates: 517422..518159 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219127.1
• Uniprot ID: A0A4J1ZS24
• Organism: Streptococcus pneumoniae strain LE4448
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 512422..523159

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
L1A14_RS02690 (L1A14_02690)	-	513398..513592 (-)	195	WP_001808905.1	hypothetical protein	-
L1A14_RS02695 (L1A14_02695)	-	513754..514041 (-)	288	WP_000777760.1	hypothetical protein	-
L1A14_RS02700 (L1A14_02700)	-	514051..514461 (-)	411	WP_001278301.1	HIT family protein	-
L1A14_RS02705 (L1A14_02705)	pptA	514529..515260 (+)	732	WP_000889923.1	ABC transporter ATP-binding protein	Regulator
L1A14_RS02710 (L1A14_02710)	-	515257..516306 (+)	1050	WP_000653752.1	ABC transporter permease	-
L1A14_RS02715 (L1A14_02715)	-	516474..516803 (-)	330	WP_000132570.1	hypothetical protein	-
L1A14_RS02720 (L1A14_02720)	-	517079..517417 (+)	339	WP_000682119.1	LytTR family DNA-binding domain-containing protein	-
L1A14_RS02725 (L1A14_02725)	comE/blpR	517422..518159 (+)	738	WP_001219127.1	response regulator transcription factor	Regulator
L1A14_RS02730 (L1A14_02730)	-	518173..519513 (+)	1341	WP_001017622.1	sensor histidine kinase	-
L1A14_RS02735 (L1A14_02735)	blpC	519555..519710 (-)	156	WP_000358813.1	quorum-sensing system pheromone BlpC	-
L1A14_RS02740 (L1A14_02740)	-	519767..521128 (-)	1362	WP_001069092.1	bacteriocin secretion accessory protein	-
L1A14_RS10505	comA/nlmT	521139..521627 (-)	489	WP_307774349.1	ATP-binding cassette domain-containing protein	Regulator
L1A14_RS10510	comA/nlmT	521611..522051 (-)	441	WP_001808911.1	ATP-binding cassette domain-containing protein	Regulator
L1A14_RS10515	comA/nlmT	522041..522766 (-)	726	WP_167750760.1	ABC transporter transmembrane domain-containing protein	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28683.81 Da
• Isoelectric Point: 6.0431

>NTDB_id=645671 L1A14_RS02725 WP_001219127.1 517422..518159(+) (comE/blpR) [Streptococcus pneumoniae strain LE4448]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIREQD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPSLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=645671 L1A14_RS02725 WP_001219127.1 517422..518159(+) (comE/blpR) [Streptococcus pneumoniae strain LE4448]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCAGAGGTACATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTAGCTAGAAAGATTCGGGAACAAGAC
CCTTATGCCCTAATCGTCTTTGTGACGACTCACTCGGAGTTTATGCCTCTGTCCTTTCGCTACCAAGTGTCAGCTTTGGA
CTACATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAATATCCTTTCAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACGGACAGGCTAGAATTTACGGCGAGTTTAGAGGA
GGTTTTTAAGCAGGAACCCAGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGCTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: A0A4J1ZS24

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	53.498	99.184	0.531
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.843	98.776	0.384