Detailed information NTG0645376

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: L0998_RS01325
• Genome accession: NZ_CP090876
• Coordinates: 276704..277747 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain SAUR_BFS12
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 271704..282747

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
L0998_RS01295 (L0998_01295)	-	271765..271875 (+)	111	WP_001790257.1	hypothetical protein	-
L0998_RS01300 (L0998_01300)	-	271904..272317 (+)	414	WP_077446671.1	hypothetical protein	-
L0998_RS01305 (L0998_01305)	-	272826..273812 (-)	987	WP_054189634.1	FUSC family protein	-
L0998_RS01310 (L0998_01310)	map	274630..275388 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
L0998_RS01315 (L0998_01315)	-	275605..275991 (+)	387	WP_001110179.1	hypothetical protein	-
L0998_RS01320 (L0998_01320)	liaF	276006..276707 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
L0998_RS01325 (L0998_01325)	vraS	276704..277747 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
L0998_RS01330 (L0998_01330)	vraR	277737..278366 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
L0998_RS01335 (L0998_01335)	-	278476..279693 (-)	1218	WP_000037088.1	YihY/virulence factor BrkB family protein	-
L0998_RS01340 (L0998_01340)	-	279971..280246 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
L0998_RS01345 (L0998_01345)	-	280253..280717 (-)	465	WP_054189636.1	low molecular weight protein-tyrosine-phosphatase	-
L0998_RS01350 (L0998_01350)	-	280864..281064 (+)	201	WP_000180460.1	DUF1128 family protein	-
L0998_RS01355 (L0998_01355)	-	281067..282323 (+)	1257	WP_077446664.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=645376 L0998_RS01325 WP_001017131.1 276704..277747(+) (vraS) [Staphylococcus aureus strain SAUR_BFS12]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=645376 L0998_RS01325 WP_001017131.1 276704..277747(+) (vraS) [Staphylococcus aureus strain SAUR_BFS12]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTTATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACGGTTGGTATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAACGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACAAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTCCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCACTTGGTTTAAAAG
ACAAATCATTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1