Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpC   Type   Regulator
Locus tag   SPB_RS01765 Genome accession   NZ_AEUT02000001
Coordinates   353187..355295 (-) Length   702 a.a.
NCBI ID   WP_003105519.1    Uniprot ID   A0A854WD63
Organism   Streptococcus parauberis NCFD 2020     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 324415..355295 353187..355295 within 0


Gene organization within MGE regions


Location: 324415..355295
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPB_RS01625 (SPB_0332) - 324415..325035 (+) 621 WP_037621088.1 glycoside hydrolase family 73 protein -
  SPB_RS01630 (SPB_0333) - 325176..325979 (+) 804 WP_003105112.1 glycoside hydrolase family 73 protein -
  SPB_RS01635 (SPB_0334) - 326039..326560 (+) 522 WP_003104315.1 hypothetical protein -
  SPB_RS01640 (SPB_0335) - 326634..327014 (+) 381 WP_003103937.1 DUF1149 family protein -
  SPB_RS01645 (SPB_0336) - 327014..327862 (+) 849 WP_003104962.1 DegV family protein -
  SPB_RS01650 (SPB_0337) dapB 327880..328647 (+) 768 WP_003105813.1 4-hydroxy-tetrahydrodipicolinate reductase -
  SPB_RS01655 (SPB_0338) - 328644..329855 (+) 1212 WP_003102825.1 CCA tRNA nucleotidyltransferase -
  SPB_RS01660 (SPB_0339) - 329848..331725 (+) 1878 WP_003104195.1 ABC-F family ATP-binding cassette domain-containing protein -
  SPB_RS01665 (SPB_0340) - 331729..332202 (+) 474 WP_003105038.1 GNAT family N-acetyltransferase -
  SPB_RS01670 (SPB_0341) - 332337..334073 (+) 1737 WP_003102488.1 ABC transporter ATP-binding protein -
  SPB_RS01675 (SPB_0342) - 334073..335842 (+) 1770 WP_003103430.1 ABC transporter ATP-binding protein -
  SPB_RS01680 (SPB_0343) gdhA 335973..337319 (+) 1347 WP_003102566.1 NADP-specific glutamate dehydrogenase -
  SPB_RS01685 (SPB_0344) - 337386..337796 (+) 411 WP_003104023.1 peptide deformylase -
  SPB_RS01690 (SPB_0345) - 337834..338019 (-) 186 WP_003102863.1 hypothetical protein -
  SPB_RS10955 - 338169..338348 (-) 180 Protein_339 hypothetical protein -
  SPB_RS01700 (SPB_0347) - 338742..340463 (+) 1722 WP_003105372.1 ABC transporter ATP-binding protein -
  SPB_RS01705 (SPB_0348) - 340465..342207 (+) 1743 WP_003104485.1 ABC transporter ATP-binding protein -
  SPB_RS01710 (SPB_0349) mvk 342370..343248 (+) 879 WP_003105664.1 mevalonate kinase -
  SPB_RS01715 (SPB_0350) mvaD 343230..344165 (+) 936 WP_003104536.1 diphosphomevalonate decarboxylase -
  SPB_RS01720 (SPB_0351) - 344166..345167 (+) 1002 WP_003104029.1 phosphomevalonate kinase -
  SPB_RS01725 (SPB_0352) fni 345167..346162 (+) 996 WP_003102845.1 type 2 isopentenyl-diphosphate Delta-isomerase -
  SPB_RS01730 (SPB_0353) - 346225..347508 (-) 1284 WP_003106052.1 hydroxymethylglutaryl-CoA reductase, degradative -
  SPB_RS01735 (SPB_0354) - 347505..348671 (-) 1167 WP_003104825.1 hydroxymethylglutaryl-CoA synthase -
  SPB_RS01740 (SPB_0355) - 348863..349702 (+) 840 WP_003105934.1 thymidylate synthase -
  SPB_RS01745 (SPB_0356) - 349779..350294 (+) 516 WP_003104878.1 dihydrofolate reductase -
  SPB_RS01750 (SPB_0358) clpX 350499..351728 (+) 1230 WP_003103169.1 ATP-dependent Clp protease ATP-binding subunit ClpX Regulator
  SPB_RS01755 (SPB_0359) yihA 351737..352336 (+) 600 WP_003104323.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
  SPB_RS01760 (SPB_0360) - 352706..353164 (+) 459 WP_003103232.1 hypothetical protein -
  SPB_RS01765 (SPB_0361) clpC 353187..355295 (-) 2109 WP_003105519.1 AAA family ATPase Regulator

Sequence

Protein


Download         Length: 702 a.a.        Molecular weight: 77655.54 Da        Isoelectric Point: 4.8649

>NTDB_id=64536 SPB_RS01765 WP_003105519.1 353187..355295(-) (clpC) [Streptococcus parauberis NCFD 2020]
MTNYYGKDPFGSMDDIFNQLMGNTGGYQTENRRYLVNGREMTPEEFQEYRQTGKLSSTAPTQEQGYPQNQKEDGILNQLG
TNLTEEARQGHLDPVIGRNKEIQDTAEILARRTKNNPVLVGDAGVGKTAVVEGLAQAIVAGDVPAAIKNKEIISIDISGL
EAGTQYRGAFEENIQNLIKEVKEAGNVILFFDEIHQILGAGSTGGDSGSKGLADILKPALSRGELTVIGATTQDEYRNTI
LKNAALARRFNEVKVNAPSAEDTFHILMGIRNLYEQHHNVILPDSVLKAAVDYSVQYIPQRSLPDKAIDLIDMTAAHLAA
QHPVTDLKSLETAIASEKDKQEKAVAAEDYELALQAKVRIEELQKQMANHTEGQKVTATINDVAESVERLTGVPVSNMGA
SDLERLKEIGNRLRGHVIGQDQAVQAVAKAIRRNRAGFDDGNRPIGSFLFVGPTGVGKTELAKQLALDMFGSKDAIIRLD
MSEYSDRTAVSKLIGTTAGYVGYDDNQYTLTERVRRNPYSIILLDEIEKADPQVITLLLQVLDDGRLTDGQGNTIDFKNT
VIIATSNAGFGNEALTGQEDHDQKIMDRIAPYFRPEFLNRFNGVIEFSHLEKKDLKEIVELMLTEVNQTINKKGITLEVT
EPVKEELIELGYDKAMGVRPLRRVIEQEIRDRITDYYLEHPDDKHLKANLADGQIVISKQDK

Nucleotide


Download         Length: 2109 bp        

>NTDB_id=64536 SPB_RS01765 WP_003105519.1 353187..355295(-) (clpC) [Streptococcus parauberis NCFD 2020]
ATGACAAACTATTATGGAAAAGACCCTTTTGGTAGCATGGATGACATTTTTAATCAATTGATGGGTAACACAGGCGGTTA
TCAAACTGAAAATCGTCGTTACCTAGTTAATGGGCGTGAAATGACACCTGAAGAATTTCAAGAATATCGACAAACTGGTA
AGCTCAGTTCTACTGCTCCTACTCAGGAACAAGGCTATCCCCAAAATCAAAAAGAAGATGGCATTCTAAACCAATTGGGT
ACCAACTTAACTGAAGAAGCACGACAAGGACACTTAGATCCAGTCATTGGACGAAATAAAGAAATTCAAGATACAGCTGA
AATATTAGCTCGCCGGACCAAGAACAATCCCGTTCTAGTAGGTGATGCGGGGGTTGGTAAAACAGCTGTGGTCGAAGGCT
TAGCCCAAGCTATCGTTGCTGGTGACGTCCCTGCTGCCATTAAAAACAAAGAAATTATTTCTATTGATATTTCCGGCTTA
GAAGCAGGTACTCAATACCGTGGTGCTTTTGAAGAAAATATTCAGAATTTAATTAAAGAAGTTAAAGAAGCCGGAAATGT
TATCCTCTTCTTTGATGAAATTCATCAAATTTTAGGCGCTGGCTCAACAGGTGGTGATTCTGGTTCCAAAGGCTTGGCCG
ATATTCTTAAACCAGCCCTATCTCGTGGCGAGTTGACCGTCATCGGTGCGACAACTCAAGATGAATATCGAAACACTATT
CTGAAAAATGCGGCCTTGGCTCGTCGTTTTAACGAAGTTAAAGTCAATGCGCCTTCTGCCGAAGATACCTTCCACATTTT
GATGGGTATCAGGAATCTTTATGAGCAACACCACAACGTCATTCTTCCGGATTCTGTTTTGAAAGCAGCCGTGGATTACT
CCGTTCAGTACATTCCACAGCGTAGTCTTCCTGACAAAGCCATCGATTTAATTGACATGACGGCTGCCCATTTAGCTGCG
CAACACCCAGTCACTGATTTGAAGAGTCTTGAAACAGCAATTGCTAGTGAGAAAGACAAGCAAGAAAAGGCTGTCGCTGC
AGAAGATTATGAGTTAGCCTTGCAAGCTAAAGTACGAATTGAAGAATTACAAAAGCAAATGGCAAACCATACCGAAGGTC
AAAAAGTGACCGCAACCATCAACGATGTCGCCGAATCAGTTGAACGTCTAACCGGCGTACCAGTTTCCAATATGGGCGCA
AGTGACTTAGAACGTTTGAAAGAAATTGGCAACCGACTTAGAGGACATGTCATCGGACAGGATCAAGCTGTTCAAGCAGT
CGCAAAGGCTATCCGTCGTAACCGTGCCGGCTTTGATGATGGCAATCGCCCAATTGGGTCATTCCTCTTTGTTGGTCCGA
CCGGCGTTGGTAAAACGGAATTAGCCAAACAGCTTGCGCTTGACATGTTTGGTTCCAAGGATGCGATCATTCGTTTAGAT
ATGTCAGAATACAGTGATCGCACTGCCGTTTCTAAATTGATTGGGACTACTGCTGGTTATGTTGGTTACGACGACAATCA
ATACACATTAACTGAACGTGTCCGTCGTAATCCATACTCAATTATTTTACTGGATGAAATTGAAAAAGCAGACCCACAAG
TCATTACCCTACTACTCCAAGTATTAGATGATGGTCGTTTAACTGATGGCCAAGGTAATACGATTGACTTCAAAAATACT
GTGATTATTGCTACATCTAATGCTGGTTTTGGCAATGAAGCATTAACGGGTCAAGAAGATCATGACCAAAAAATTATGGA
CCGAATCGCTCCTTATTTTAGACCTGAATTCTTAAATCGTTTTAATGGTGTGATAGAATTCTCACATCTAGAAAAAAAGG
ATTTGAAAGAAATTGTTGAATTAATGTTAACGGAAGTTAATCAAACAATCAATAAAAAAGGTATCACTTTAGAAGTAACA
GAACCTGTTAAAGAGGAACTAATTGAATTAGGATATGACAAAGCTATGGGAGTTAGACCATTACGCCGTGTCATTGAACA
AGAAATCCGTGATCGTATAACAGACTATTATTTGGAACATCCCGATGATAAACATCTAAAAGCAAATTTAGCAGATGGTC
AAATTGTGATTAGTAAACAAGACAAATGA

Domains

Predicted by InterproScan.

AAA lid domain (AAA_lid_9)

(259-353)

ATPase family associated with various cellular activities (AAA) (AAA)

(118-250)

AAA domain (Cdc48 subfamily) (AAA_2)

(443-602)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(610-680)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A854WD63

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpC Lactococcus lactis subsp. cremoris KW2

48.515

100

0.489
  clpE Streptococcus mutans UA159

47.532

100

0.48
  clpE Streptococcus pneumoniae Rx1

46.968

100

0.474
  clpE Streptococcus pneumoniae D39

46.968

100

0.474
  clpE Streptococcus pneumoniae R6

46.968

100

0.474
  clpE Streptococcus pneumoniae TIGR4

46.968

100

0.474
  clpC Bacillus subtilis subsp. subtilis str. 168

44.651

91.88

0.41
  clpC Streptococcus pneumoniae TIGR4

41.617

95.157

0.396
  clpC Streptococcus pneumoniae Rx1

41.617

95.157

0.396
  clpC Streptococcus pneumoniae D39

41.617

95.157

0.396
  clpC Streptococcus mutans UA159

40.399

92.735

0.375
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

41.842

88.177

0.369
  clpC Streptococcus thermophilus LMG 18311

41.44

89.031

0.369
  clpC Streptococcus thermophilus LMD-9

41.506

88.889

0.369

Multiple sequence alignment