Detailed information NTG0643586

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KB225_RS04275
• Genome accession: NZ_CP090575
• Coordinates: 917058..918104 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain 11H
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 912058..923104

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KB225_RS04250 (KB225_04250)	isaB	913199..913735 (+)	537	WP_001830372.1	immunodominant staphylococcal antigen IsaB family protein	-
KB225_RS04255 (KB225_04255)	-	913886..914872 (-)	987	WP_020368335.1	FUSC family protein	-
KB225_RS04260 (KB225_04260)	map	915046..915801 (+)	756	WP_001830397.1	type I methionyl aminopeptidase	-
KB225_RS04265 (KB225_04265)	-	915959..916345 (+)	387	WP_001830382.1	hypothetical protein	-
KB225_RS04270 (KB225_04270)	liaF	916360..917061 (+)	702	WP_002457093.1	cell wall-active antibiotics response protein LiaF	-
KB225_RS04275 (KB225_04275)	vraS	917058..918104 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
KB225_RS04280 (KB225_04280)	vraR	918094..918723 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
KB225_RS04285 (KB225_04285)	-	918780..919958 (-)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
KB225_RS04290 (KB225_04290)	-	920365..920649 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
KB225_RS04295 (KB225_04295)	-	920657..921121 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
KB225_RS04300 (KB225_04300)	-	921262..921477 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
KB225_RS04305 (KB225_04305)	-	921479..922705 (+)	1227	WP_234773845.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=643586 KB225_RS04275 WP_001830374.1 917058..918104(+) (vraS) [Staphylococcus epidermidis strain 11H]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=643586 KB225_RS04275 WP_001830374.1 917058..918104(+) (vraS) [Staphylococcus epidermidis strain 11H]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92