Detailed information NTG0641829

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: LZ178_RS09935
• Genome accession: NZ_CP090375
• Coordinates: 2052120..2053163 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain GD4SA108-1
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2047120..2058163

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LZ178_RS09905 (LZ178_09885)	-	2047541..2048797 (-)	1257	WP_074347694.1	aminopeptidase	-
LZ178_RS09910 (LZ178_09890)	-	2048800..2049000 (-)	201	WP_000180460.1	DUF1128 family protein	-
LZ178_RS09915 (LZ178_09895)	-	2049147..2049611 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
LZ178_RS09920 (LZ178_09900)	-	2049618..2049893 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
LZ178_RS09925 (LZ178_09905)	-	2050171..2051388 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
LZ178_RS09930 (LZ178_09910)	vraR	2051501..2052130 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
LZ178_RS09935 (LZ178_09915)	vraS	2052120..2053163 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
LZ178_RS09940 (LZ178_09920)	liaF	2053160..2053861 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
LZ178_RS09945 (LZ178_09925)	-	2053876..2054262 (-)	387	WP_001110182.1	hypothetical protein	-
LZ178_RS09950 (LZ178_09930)	map	2054479..2055237 (-)	759	WP_000636145.1	type I methionyl aminopeptidase	-
LZ178_RS09955 (LZ178_09935)	-	2055821..2056807 (+)	987	WP_000999712.1	aromatic acid exporter family protein	-
LZ178_RS09960 (LZ178_09940)	-	2056996..2057409 (-)	414	WP_078064776.1	hypothetical protein	-
LZ178_RS09965 (LZ178_09945)	-	2057438..2057548 (-)	111	WP_014937049.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=641829 LZ178_RS09935 WP_001017131.1 2052120..2053163(-) (vraS) [Staphylococcus aureus strain GD4SA108-1]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=641829 LZ178_RS09935 WP_001017131.1 2052120..2053163(-) (vraS) [Staphylococcus aureus strain GD4SA108-1]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1