Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   LZ178_RS00195 Genome accession   NZ_CP090375
Coordinates   50758..52107 (-) Length   449 a.a.
NCBI ID   WP_257241390.1    Uniprot ID   -
Organism   Staphylococcus aureus strain GD4SA108-1     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 49113..65931 50758..52107 within 0


Gene organization within MGE regions


Location: 49113..65931
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  LZ178_RS00190 (LZ178_00190) ccrB 49113..50738 (-) 1626 WP_257241389.1 recombinase family protein Machinery gene
  LZ178_RS00195 (LZ178_00195) ccrA 50758..52107 (-) 1350 WP_257241390.1 recombinase family protein Machinery gene
  LZ178_RS00200 (LZ178_00200) - 52299..52574 (-) 276 WP_053027474.1 hypothetical protein -
  LZ178_RS00205 (LZ178_00205) - 52643..54430 (-) 1788 WP_044466492.1 DUF927 domain-containing protein -
  LZ178_RS00210 (LZ178_00210) - 54556..55983 (-) 1428 WP_259489399.1 DUF6038 family protein -
  LZ178_RS00215 (LZ178_00215) - 56408..57082 (-) 675 WP_072291720.1 IS6-like element IS257 family transposase -
  LZ178_RS00220 (LZ178_00220) fexB 57732..59141 (-) 1410 WP_002415211.1 chloramphenicol/florfenicol efflux MFS transporter FexB -
  LZ178_RS00225 (LZ178_00225) - 59546..59713 (-) 168 Protein_42 recombinase family protein -
  LZ178_RS00230 (LZ178_00230) - 59770..60450 (-) 681 WP_002325565.1 IS6-like element IS1216 family transposase -
  LZ178_RS00235 (LZ178_00235) poxtA 60504..62132 (-) 1629 WP_002415638.1 ABC-F type ribosomal protection protein PoxtA -
  LZ178_RS00240 (LZ178_00240) - 63003..63677 (-) 675 WP_072291720.1 IS6-like element IS257 family transposase -
  LZ178_RS00245 (LZ178_00245) - 63718..63825 (-) 108 Protein_46 beta-lactam sensor/signal transducer MecR1 -
  LZ178_RS00250 (LZ178_00250) mecA 63922..65931 (+) 2010 WP_194376038.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 52051.66 Da        Isoelectric Point: 10.0659

>NTDB_id=641790 LZ178_RS00195 WP_257241390.1 50758..52107(-) (ccrA) [Staphylococcus aureus strain GD4SA108-1]
MKQAIGYLRQSTLKQQSLAAQKQTIKALAEKHSIQHITFYSDKQSGRTDKRNGYQQITELIQQGQCDVLCCYRLNRLHRN
LKNALKLMKLCQTYHVHILSVHDGYFDMDKAFDRLKLNIFISLAELESDNIGEQVKNGIKEKAKQGKLITTHAPFGYHYH
NGTFTINKSEAPTVKAVFSYYLQGYGYKKIAQYLEANEKFINRKPYQVRNIIMNSNYCGRVINQYGQYDNMFPSIVSTNI
YEQAQAIRSQKQLKRTSSANQLKQKIKCPCCSSTLTNMTIRKKHHTLRYYVCPQNLNASRFVCEFKGINAQALEASVLST
CQDFFQNQHLYSKINHTIQQRLKKQKDIEAKSTVTQEQLIEKLAQGKIDAETFREQTQSFRQQSKPITSIHTHQIQKALQ
NVMQQRFTLNILYPYIDEIHITKNKTLTGIYFKNEPLNIVNQTTQSSIA

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=641790 LZ178_RS00195 WP_257241390.1 50758..52107(-) (ccrA) [Staphylococcus aureus strain GD4SA108-1]
ATGAAACAAGCAATTGGTTACTTACGTCAAAGTACACTCAAACAACAATCTCTAGCAGCACAGAAACAGACCATCAAAGC
ACTAGCCGAAAAACACAGTATTCAACACATTACCTTTTATAGCGATAAGCAATCAGGACGCACTGATAAGCGAAATGGTT
ACCAACAAATTACTGAACTGATTCAACAGGGACAATGTGACGTATTATGTTGCTATCGTCTAAATCGACTTCATCGTAAT
CTAAAAAATGCATTAAAGCTCATGAAATTATGTCAAACGTATCATGTTCATATCTTAAGCGTTCATGATGGCTACTTCGA
CATGGATAAAGCATTCGATCGGCTCAAACTCAATATTTTCATCAGCTTGGCCGAACTAGAATCTGATAATATAGGCGAAC
AAGTCAAAAATGGAATCAAAGAAAAAGCAAAACAAGGTAAACTCATCACGACTCATGCACCCTTTGGCTATCACTATCAT
AATGGGACATTCACAATAAACAAGTCAGAAGCACCAACAGTAAAAGCTGTATTCAGTTACTATCTTCAAGGATATGGCTA
TAAAAAAATTGCGCAATACTTAGAAGCTAATGAGAAATTTATCAATCGTAAACCCTATCAAGTACGTAATATTATCATGA
ACTCTAATTATTGTGGTCGAGTCATTAATCAATACGGACAATATGACAACATGTTCCCTTCTATTGTTTCGACTAATATA
TATGAACAAGCTCAAGCCATACGTTCACAAAAGCAACTCAAACGGACATCATCAGCTAATCAACTCAAACAAAAAATCAA
ATGTCCGTGTTGTAGCTCAACACTCACAAATATGACCATTAGAAAAAAGCACCATACATTACGTTATTATGTCTGTCCTC
AAAATTTGAATGCATCTCGTTTTGTCTGTGAATTCAAGGGCATCAACGCACAAGCATTAGAAGCGAGTGTCTTATCTACA
TGTCAAGACTTCTTTCAAAATCAACATCTGTATTCGAAAATCAACCATACAATTCAACAACGACTCAAAAAACAAAAAGA
CATAGAAGCTAAAAGTACAGTCACGCAAGAACAACTGATAGAAAAATTAGCCCAAGGCAAAATTGATGCAGAAACATTCA
GAGAACAAACGCAATCATTTCGACAACAGTCAAAACCTATAACATCAATCCATACGCATCAAATTCAAAAGGCTTTACAA
AATGTCATGCAACAACGTTTCACATTAAACATATTGTACCCTTACATTGATGAAATTCATATTACCAAAAATAAAACACT
TACGGGTATCTATTTCAAAAACGAGCCCTTAAACATCGTCAATCAAACAACACAATCATCGATTGCTTAA

Domains

Predicted by InterproScan.

Resolvase, N terminal domain (Resolvase)

(4-147)

Recombinase (Recombinase)

(169-250)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-322)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus COL

86.414

100

0.864
  ccrA Staphylococcus aureus N315

78.174

100

0.782