Detailed information    

insolico Bioinformatically predicted

Overview

Name   comM   Type   Regulator
Locus tag   LXA46_RS09240 Genome accession   NZ_CP089948
Coordinates   1840845..1841465 (-) Length   206 a.a.
NCBI ID   WP_000839908.1    Uniprot ID   A0A0B7M636
Organism   Streptococcus pneumoniae TIGR4     
Function   fratricide immunity (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1830341..1852532 1840845..1841465 within 0


Gene organization within MGE regions


Location: 1830341..1852532
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  LXA46_RS09180 (LXA46_09170) - 1830341..1831135 (-) 795 WP_001101210.1 hypothetical protein -
  LXA46_RS09185 (LXA46_09175) - 1831543..1831968 (-) 426 WP_000204063.1 hypothetical protein -
  LXA46_RS09190 (LXA46_09180) - 1832097..1832456 (-) 360 WP_000749819.1 hypothetical protein -
  LXA46_RS09195 (LXA46_09185) - 1832502..1832708 (-) 207 WP_000366093.1 hypothetical protein -
  LXA46_RS09200 (LXA46_09190) - 1832695..1832856 (-) 162 WP_000289348.1 helix-turn-helix transcriptional regulator -
  LXA46_RS09205 (LXA46_09195) lytA 1833214..1834170 (-) 957 WP_000405234.1 N-acetylmuramoyl-L-alanine amidase LytA -
  LXA46_RS09210 (LXA46_09200) - 1834546..1835916 (-) 1371 WP_001036271.1 MATE family efflux transporter -
  LXA46_RS09215 (LXA46_09205) recA 1836222..1837388 (-) 1167 WP_001085462.1 recombinase RecA Machinery gene
  LXA46_RS09220 (LXA46_09210) cinA 1837443..1838699 (-) 1257 WP_000642718.1 competence/damage-inducible protein A Machinery gene
  LXA46_RS09225 (LXA46_09215) - 1838784..1839800 (-) 1017 WP_000239283.1 LCP family protein -
  LXA46_RS09230 (LXA46_09220) - 1839808..1840326 (-) 519 WP_000455537.1 GNAT family N-acetyltransferase -
  LXA46_RS09235 (LXA46_09225) tsaE 1840316..1840759 (-) 444 WP_000288232.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
  LXA46_RS09240 (LXA46_09230) comM 1840845..1841465 (-) 621 WP_000839908.1 hypothetical protein Regulator
  LXA46_RS09245 (LXA46_09235) - 1841848..1842711 (-) 864 WP_001093641.1 helix-turn-helix transcriptional regulator -
  LXA46_RS09250 - 1842903..1843073 (+) 171 WP_001227862.1 PhrA family quorum-sensing system peptide -
  LXA46_RS09255 (LXA46_09240) pneA1 1843176..1843400 (+) 225 WP_000181087.1 two-peptide bacteriocin subunit PneA1 -
  LXA46_RS09260 (LXA46_09245) pneA2 1843407..1843595 (+) 189 WP_000786759.1 two-peptide bacteriocin subunit PneA2 -
  LXA46_RS09265 (LXA46_09250) lanM 1843711..1846701 (+) 2991 WP_000875573.1 type 2 lanthipeptide synthetase LanM -
  LXA46_RS09270 (LXA46_09255) - 1847051..1847755 (+) 705 WP_001033170.1 flavodoxin family protein -
  LXA46_RS09275 (LXA46_09260) - 1847736..1848665 (+) 930 WP_000912954.1 M50 family metallopeptidase -
  LXA46_RS09280 (LXA46_09265) - 1848662..1850770 (+) 2109 WP_000701298.1 peptidase domain-containing ABC transporter -
  LXA46_RS09285 (LXA46_09270) - 1850794..1852206 (+) 1413 WP_000699968.1 S8 family serine peptidase -
  LXA46_RS09290 (LXA46_09275) - 1852260..1852532 (+) 273 WP_000939671.1 hypothetical protein -

Sequence

Protein


Download         Length: 206 a.a.        Molecular weight: 23552.72 Da        Isoelectric Point: 10.1254

>NTDB_id=639355 LXA46_RS09240 WP_000839908.1 1840845..1841465(-) (comM) [Streptococcus pneumoniae TIGR4]
MKSMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFVSGICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLL
INLLGAVLVLSDNLFIKNTLQQELVDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKKTVLVTILATLLFLRNPMTI
VSLLIYIGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFF

Nucleotide


Download         Length: 621 bp        

>NTDB_id=639355 LXA46_RS09240 WP_000839908.1 1840845..1841465(-) (comM) [Streptococcus pneumoniae TIGR4]
ATGAAATCAATGAGAATCTTATTTTTGTTAGCTTTAATTCAAATCAGTTTGAGTAGCTGTTTCCTATGGAAGGAATGCAT
CTTGTCCTTTAAACAAAGTACAGCTTTTTTCATCGGAAGCATGGTTTTCGTTTCAGGAATCTGTGCTGGAGTAAATTATC
TTTATACCCGTAAGCAAGAAGTCCATAGTGTCCTAGCCAGTAAGAAGTCGGTGAAGCTTTTTTACAGTATGTTACTCTTA
ATTAATTTGTTAGGAGCTGTTCTTGTTTTGTCAGATAACTTGTTCATCAAAAATACGCTGCAGCAAGAATTAGTTGACTT
TTTATTGCCATCCTTCTTTTTCCTATTTGGGCTAGATTTGCTGATTTTTTTACCCTTGAAAAAATACGTGCGCGATTTTC
TTGCTATGCTGGACAGAAAAAAGACAGTGTTGGTGACTATTTTAGCAACACTTCTTTTCTTAAGAAATCCAATGACCATT
GTCTCACTTCTGATTTATATTGGACTGGGCTTGTTTTTTGCAGCCTATCTTGTCCCAAATTCGGTTAAGAAGGAAGTTTC
CTTTTATGGTCATATTTTCCGAGATCTTGTATTGGTCATTGTTACGCTCATTTTCTTTTAG

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7M636

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comM Streptococcus pneumoniae D39

100

100

1
  comM Streptococcus pneumoniae R6

100

100

1
  comM Streptococcus pneumoniae TIGR4

100

100

1
  comM Streptococcus mitis NCTC 12261

38.974

94.66

0.369
  comM Streptococcus mitis SK321

38.974

94.66

0.369