Detailed information NTG0637791

Bioinformatically predicted

Overview

• Name: ccrB
• Type: Machinery gene
• Locus tag: LUY95_RS11060
• Genome accession: NZ_CP089506
• Coordinates: 2186940..2188568 (+)
• Length: 542 a.a.
• NCBI ID: WP_001186599.1
• Uniprot ID: M1XHS4
• Organism: Staphylococcus aureus strain 0.0066_IIV_ST239
• Function: promote SCCmec transfer (predicted from homology) Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
SCCmec	2185569..2206934	2186940..2188568	within	0

Gene organization within MGE regions

Location: 2185569..2206934

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LUY95_RS11055	ccrA	2185569..2186918 (+)	1350	WP_000815654.1	cassette chromosome recombinase CcrA	Machinery gene
LUY95_RS11060	ccrB	2186940..2188568 (+)	1629	WP_001186599.1	cassette chromosome recombinase CcrB	Machinery gene
LUY95_RS11065	-	2189086..2189436 (+)	351	WP_000859155.1	SAUGI family uracil-DNA glycosylase inhibitor	-
LUY95_RS11070	-	2189523..2189834 (+)	312	WP_000700853.1	DUF960 family protein	-
LUY95_RS11075	-	2189852..2190358 (+)	507	WP_001092169.1	DUF1643 domain-containing protein	-
LUY95_RS11080	-	2190379..2190696 (+)	318	WP_000659050.1	JAB domain-containing protein	-
LUY95_RS11085	-	2190815..2191900 (+)	1086	WP_000868132.1	tyrosine-type recombinase/integrase	-
LUY95_RS11090	-	2191897..2193789 (+)	1893	WP_001557544.1	site-specific integrase	-
LUY95_RS11095	-	2193796..2194173 (+)	378	WP_000361059.1	DUF6262 family protein	-
LUY95_RS11100	-	2194324..2195106 (+)	783	WP_000067268.1	aminoglycoside nucleotidyltransferase ANT(9)-Ia	-
LUY95_RS11105	erm(A)	2195232..2195963 (-)	732	WP_001072201.1	23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A)	-
LUY95_RS11110	-	2196046..2196105 (-)	60	WP_010959190.1	erythromycin resistance leader peptide	-
LUY95_RS11115	-	2196497..2197159 (+)	663	WP_001092058.1	class I SAM-dependent methyltransferase	-
LUY95_RS11120	-	2197504..2198142 (-)	639	Protein_2160	sulfite exporter TauE/SafE family protein	-
LUY95_RS11125	cstR	2198142..2198402 (-)	261	WP_000220507.1	persulfide-sensing transcriptional repressor CstR	-
LUY95_RS11130	-	2198538..2199602 (+)	1065	WP_000438836.1	DsrE/DsrF/DrsH-like family protein	-
LUY95_RS11135	cstB	2199635..2200969 (+)	1335	Protein_2163	persulfide dioxygenase-sulfurtransferase CstB	-
LUY95_RS11140	-	2201083..2202192 (-)	1110	WP_001643603.1	ROK family transcriptional regulator	-
LUY95_RS11145	psm-mec	2202547..2202615 (+)	69	WP_014532405.1	phenol-soluble modulin PSM-mec	-
LUY95_RS11150	mecI	2202727..2203071 (-)	345	WP_000369213.1	mecA-type methicillin resistance repressor MecI	-
LUY95_RS11155	mecR1	2203071..2204828 (-)	1758	WP_000952923.1	beta-lactam sensor/signal transducer MecR1	-
LUY95_RS11160	mecA	2204925..2206934 (+)	2010	WP_001801873.1	PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA	-

Sequence

Protein

• Length: 542 a.a.
• Molecular weight: 62650.81 Da
• Isoelectric Point: 9.8600

>NTDB_id=637791 LUY95_RS11060 WP_001186599.1 2186940..2188568(+) (ccrB) [Staphylococcus aureus strain 0.0066_IIV_ST239]
MQQLKTKRVGIYVRVSTEMQSTEGYSIDGQINQIKEYCDFHHFEVKDIYADRGISGKSMNRPELQRILKDAKDGYIDCVM
VYKTNRLARNTSDLLKIVEDLHKQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPNSKHELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGKPFSISSITYILANPFYIGKIQFAK
YKDWSEKRRKGLNDKPVIAEGKHSPIINQDLWDKVQMRKKQVSQKPQVHGKGTNLLTGIIHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEDYVMKQILEIVKSDKVIQRVVTHVNQENQVDGAALHHDIAYKQQQYD
EVQIKLNNLIKTIEDNPDLTSVIRPSIQKYEKQLNDITNQINQLKNQQNEDKPLFDAKEISKLLQHIFHDIKHIEKSRLK
ALYLSVIDRIDIKKDGNHKKQFYVTLKLNNEIIKQLFNNKQLDEVHLSTSSLFLPQTLYLTI

Nucleotide

• Length: 1629 bp

>NTDB_id=637791 LUY95_RS11060 WP_001186599.1 2186940..2188568(+) (ccrB) [Staphylococcus aureus strain 0.0066_IIV_ST239]
ATGCAACAACTTAAAACAAAACGTGTCGGTATCTATGTACGTGTTTCAACAGAAATGCAAAGCACAGAAGGTTATAGTAT
CGACGGACAAATCAATCAAATCAAAGAATACTGTGACTTCCATCATTTTGAAGTTAAAGATATATACGCTGACCGTGGTA
TTTCAGGTAAATCTATGAATCGACCTGAGCTCCAACGTATATTGAAGGATGCGAAAGATGGCTATATCGACTGTGTTATG
GTCTACAAAACAAACCGATTAGCTCGTAATACATCTGATCTTCTCAAAATTGTCGAAGATTTACACAAACAAAATGTCGA
ATTTTTCAGTTTATCAGAGCGTATGGAAGTCAATACTTCATCGGGTAAGCTCATGTTACAAATACTTGCGAGTTTCTCAG
AATTCGAACGTAATAACATTGTCGAGAATGTATTTATGGGTCAAACGAGACGTGCCCAAGAAGGCTATTATCAAGGCAAT
TTGCCGCTGGGCTATGACAAAATACCTAATAGTAAACATGAACTGATGATTAATCAACATGAAGCTAATATTGTGAAATA
TATATTCGAGTCCTATGCCAAAGGCCATGGCTATCGTAAAATAGCCAATGCATTAAATCACAAAGGCTATGTCACTAAAA
AGGGTAAACCTTTTAGTATTAGTTCTATCACATATATATTAGCTAACCCATTCTATATCGGCAAAATTCAATTTGCGAAA
TACAAAGATTGGAGTGAAAAACGTCGTAAAGGGCTTAATGATAAACCAGTGATAGCTGAAGGTAAGCATTCCCCCATTAT
TAATCAAGATTTATGGGATAAAGTACAAATGCGTAAAAAACAAGTCAGTCAAAAACCCCAAGTCCATGGCAAAGGAACGA
ATCTGCTTACAGGCATTATTCACTGTCCCCAATGTGGCGCACCTATGGCAGCAAGCAATACCACGAATACACTTAAAGAC
GGGACTAAGAAACGTATTCGTTACTATTCATGTAGTAATTTTCGGAACAAGGGTTCCAAAGTATGTTCGGCAAACAGTGT
AAGAGCTGATGTGATTGAAGATTATGTGATGAAGCAAATACTTGAAATAGTCAAAAGTGATAAAGTCATTCAACGCGTAG
TAACACACGTCAATCAAGAAAATCAAGTTGATGGCGCTGCACTTCATCACGATATTGCTTATAAGCAACAACAATATGAT
GAAGTACAAATCAAACTAAATAACTTGATTAAAACCATCGAGGATAATCCGGACTTAACATCAGTAATCAGACCAAGTAT
TCAAAAATATGAAAAGCAACTCAATGACATTACGAATCAAATCAACCAACTCAAAAATCAACAAAATGAAGATAAGCCTT
TATTTGATGCCAAAGAAATCAGTAAACTATTACAACACATCTTTCATGATATTAAGCACATAGAAAAATCTCGACTCAAA
GCATTGTATCTATCAGTGATTGATCGCATTGATATTAAAAAAGATGGTAATCATAAAAAACAATTCTATGTCACACTCAA
ACTTAATAACGAAATCATAAAACAACTTTTCAATAATAAACAACTCGACGAAGTGCATCTCAGCACTTCGTCTTTGTTTT
TGCCCCAAACACTATATCTTACTATTTAG

Domains

Predicted by InterproScan.

• Ogr/Delta-like zinc finger (Ogr_Delta) (301-356)

• Recombinase (Recombinase) (180-280)

• Resolvase, N terminal domain (Resolvase) (11-156)

3D structure

• AlphaFold DB: M1XHS4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ccrB	Staphylococcus aureus N315	99.815	100	0.998