Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   LUY95_RS11055 Genome accession   NZ_CP089506
Coordinates   2185569..2186918 (+) Length   449 a.a.
NCBI ID   WP_000815654.1    Uniprot ID   Q4JFB2
Organism   Staphylococcus aureus strain 0.0066_IIV_ST239     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 2185569..2206934 2185569..2186918 within 0


Gene organization within MGE regions


Location: 2185569..2206934
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  LUY95_RS11055 ccrA 2185569..2186918 (+) 1350 WP_000815654.1 cassette chromosome recombinase CcrA Machinery gene
  LUY95_RS11060 ccrB 2186940..2188568 (+) 1629 WP_001186599.1 cassette chromosome recombinase CcrB Machinery gene
  LUY95_RS11065 - 2189086..2189436 (+) 351 WP_000859155.1 SAUGI family uracil-DNA glycosylase inhibitor -
  LUY95_RS11070 - 2189523..2189834 (+) 312 WP_000700853.1 DUF960 family protein -
  LUY95_RS11075 - 2189852..2190358 (+) 507 WP_001092169.1 DUF1643 domain-containing protein -
  LUY95_RS11080 - 2190379..2190696 (+) 318 WP_000659050.1 JAB domain-containing protein -
  LUY95_RS11085 - 2190815..2191900 (+) 1086 WP_000868132.1 tyrosine-type recombinase/integrase -
  LUY95_RS11090 - 2191897..2193789 (+) 1893 WP_001557544.1 site-specific integrase -
  LUY95_RS11095 - 2193796..2194173 (+) 378 WP_000361059.1 DUF6262 family protein -
  LUY95_RS11100 - 2194324..2195106 (+) 783 WP_000067268.1 aminoglycoside nucleotidyltransferase ANT(9)-Ia -
  LUY95_RS11105 erm(A) 2195232..2195963 (-) 732 WP_001072201.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) -
  LUY95_RS11110 - 2196046..2196105 (-) 60 WP_010959190.1 erythromycin resistance leader peptide -
  LUY95_RS11115 - 2196497..2197159 (+) 663 WP_001092058.1 class I SAM-dependent methyltransferase -
  LUY95_RS11120 - 2197504..2198142 (-) 639 Protein_2160 sulfite exporter TauE/SafE family protein -
  LUY95_RS11125 cstR 2198142..2198402 (-) 261 WP_000220507.1 persulfide-sensing transcriptional repressor CstR -
  LUY95_RS11130 - 2198538..2199602 (+) 1065 WP_000438836.1 DsrE/DsrF/DrsH-like family protein -
  LUY95_RS11135 cstB 2199635..2200969 (+) 1335 Protein_2163 persulfide dioxygenase-sulfurtransferase CstB -
  LUY95_RS11140 - 2201083..2202192 (-) 1110 WP_001643603.1 ROK family transcriptional regulator -
  LUY95_RS11145 psm-mec 2202547..2202615 (+) 69 WP_014532405.1 phenol-soluble modulin PSM-mec -
  LUY95_RS11150 mecI 2202727..2203071 (-) 345 WP_000369213.1 mecA-type methicillin resistance repressor MecI -
  LUY95_RS11155 mecR1 2203071..2204828 (-) 1758 WP_000952923.1 beta-lactam sensor/signal transducer MecR1 -
  LUY95_RS11160 mecA 2204925..2206934 (+) 2010 WP_001801873.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 52665.36 Da        Isoelectric Point: 10.0809

>NTDB_id=637790 LUY95_RS11055 WP_000815654.1 2185569..2186918(+) (ccrA) [Staphylococcus aureus strain 0.0066_IIV_ST239]
MKQVIGYLRQSTMKQQSLAAQKQAIEAITEKHHIQHINFYSDKQSGRKDNRSGYRQITQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYRVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGTFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRLQKQTKQTPSDNQLKQKIKCPCCNATLTNMTIRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CRDFYQNQRIYTKIKSAIDKRIKRQRNIEKHHTLTQKQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQNTIQ
NIIQKRFTLNMLYPYIDEILITKSKTLMGIYFKNEPLNIVNQTTQSSIA

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=637790 LUY95_RS11055 WP_000815654.1 2185569..2186918(+) (ccrA) [Staphylococcus aureus strain 0.0066_IIV_ST239]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAAGCTATCGAAGC
AATAACCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATAACACAATTAATTCAACAAGGACAGTGTGACATATTATGCTGTTATCGTCTTAATAGGTTGCATCGTAAT
TTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATATCGTGTTCATATCTTAAGTGTGCATGATGGTTATTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAACATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATTATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGTCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATTGCAAAAACAAACCAAACAGACACCTTCGGATAATCAACTCAAACAAAAAATCAA
ATGCCCATGTTGTAATGCAACACTTACAAATATGACCATTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCACGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCCGAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAAGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAAAACAACTGATAGAAAAGTTGGCACAAGGCATCATTGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGGCATCAAATACAAAACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATGCTGTATCCCTACATTGATGAAATTCTTATCACAAAAAGTAAAACACT
AATGGGTATCTATTTCAAAAATGAACCCTTAAACATCGTCAATCAAACAACGCAATCGTCAATTGCATAA

Domains

Predicted by InterproScan.

Recombinase (Recombinase)

(169-248)

Resolvase, N terminal domain (Resolvase)

(4-147)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-321)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q4JFB2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus N315

95.323

100

0.953
  ccrA Staphylococcus aureus COL

75.501

100

0.755