Detailed information NTG0637544

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: LUY98_RS00455
• Genome accession: NZ_CP089497
• Coordinates: 81146..82189 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017129.1
• Uniprot ID: A0A0U1MRG1
• Organism: Staphylococcus aureus strain 3045_IIV_ST8
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 76146..87189

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LUY98_RS00425	-	76769..76878 (+)	110	Protein_84	hypothetical protein	-
LUY98_RS00430	-	76907..77323 (+)	417	WP_025174454.1	hypothetical protein	-
LUY98_RS00435	-	77499..78485 (-)	987	WP_000999711.1	aromatic acid exporter family protein	-
LUY98_RS00440	map	79072..79830 (+)	759	WP_000636137.1	type I methionyl aminopeptidase	-
LUY98_RS00445	-	80047..80433 (+)	387	WP_001110183.1	hypothetical protein	-
LUY98_RS00450	liaF	80448..81149 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
LUY98_RS00455	vraS	81146..82189 (+)	1044	WP_001017129.1	sensor histidine kinase	Regulator
LUY98_RS00460	vraR	82179..82808 (+)	630	WP_061843483.1	two-component system response regulator VraR	Regulator
LUY98_RS00465	-	82921..84138 (-)	1218	WP_000037083.1	YihY/virulence factor BrkB family protein	-
LUY98_RS00470	-	84416..84691 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
LUY98_RS00475	-	84698..85162 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
LUY98_RS00480	-	85309..85509 (+)	201	WP_001813025.1	DUF1128 family protein	-
LUY98_RS00485	-	85512..86768 (+)	1257	WP_001793428.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40060.56 Da
• Isoelectric Point: 6.0577

>NTDB_id=637544 LUY98_RS00455 WP_001017129.1 81146..82189(+) (vraS) [Staphylococcus aureus strain 3045_IIV_ST8]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQILILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=637544 LUY98_RS00455 WP_001017129.1 81146..82189(+) (vraS) [Staphylococcus aureus strain 3045_IIV_ST8]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCT
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTACCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTCGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0U1MRG1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	99.712	100	0.997