Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | LUZ08_RS10290 | Genome accession | NZ_CP089489 |
| Coordinates | 2055357..2056703 (+) | Length | 448 a.a. |
| NCBI ID | WP_000816499.1 | Uniprot ID | Q9R3W9 |
| Organism | Staphylococcus aureus strain E1174_IV_ST22 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 2055357..2110961 | 2055357..2056703 | within | 0 |
Gene organization within MGE regions
Location: 2055357..2110961
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LUZ08_RS10290 | ccrA | 2055357..2056703 (+) | 1347 | WP_000816499.1 | cassette chromosome recombinase CcrA | Machinery gene |
| LUZ08_RS10295 | ccrB | 2056724..2058352 (+) | 1629 | WP_001186596.1 | cassette chromosome recombinase CcrB | Machinery gene |
| LUZ08_RS10300 | - | 2058823..2059173 (+) | 351 | WP_000171449.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| LUZ08_RS10305 | - | 2059258..2059569 (+) | 312 | WP_000833212.1 | DUF960 family protein | - |
| LUZ08_RS10310 | - | 2059588..2060109 (+) | 522 | WP_000836008.1 | DUF1643 domain-containing protein | - |
| LUZ08_RS10315 | - | 2060111..2060317 (+) | 207 | WP_001077283.1 | hypothetical protein | - |
| LUZ08_RS10320 | - | 2060310..2060633 (+) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| LUZ08_RS10325 | - | 2060828..2062720 (+) | 1893 | WP_002485298.1 | site-specific integrase | - |
| LUZ08_RS10330 | - | 2062727..2063104 (+) | 378 | WP_001041908.1 | DUF6262 family protein | - |
| LUZ08_RS10335 | - | 2063342..2063707 (+) | 366 | WP_000159127.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| LUZ08_RS10340 | - | 2063700..2066114 (+) | 2415 | WP_000378487.1 | cadmium-translocating P-type ATPase CadA | - |
| LUZ08_RS10345 | - | 2066195..2066812 (+) | 618 | WP_000562107.1 | CadD family cadmium resistance transporter | - |
| LUZ08_RS10350 | - | 2067086..2067724 (-) | 639 | Protein_2005 | sulfite exporter TauE/SafE family protein | - |
| LUZ08_RS10355 | cstR | 2067724..2067984 (-) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| LUZ08_RS10360 | - | 2068120..2069184 (+) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| LUZ08_RS10365 | cstB | 2069217..2070551 (+) | 1335 | Protein_2008 | persulfide dioxygenase-sulfurtransferase CstB | - |
| LUZ08_RS10370 | - | 2070665..2071774 (-) | 1110 | WP_000943131.1 | ROK family transcriptional regulator | - |
| LUZ08_RS10375 | psm-mec | 2072133..2072201 (+) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| LUZ08_RS10380 | mecI | 2072286..2072657 (-) | 372 | Protein_2011 | mecA-type methicillin resistance repressor MecI | - |
| LUZ08_RS10385 | - | 2072657..2074248 (-) | 1592 | Protein_2012 | BlaR1 family beta-lactam sensor/signal transducer | - |
| LUZ08_RS10390 | mecA | 2074345..2076354 (+) | 2010 | WP_078056515.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| LUZ08_RS10395 | - | 2076400..2076828 (-) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| LUZ08_RS10400 | - | 2076925..2077668 (-) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| LUZ08_RS10405 | - | 2078545..2078934 (-) | 390 | WP_020444595.1 | hydroxymethylglutaryl-CoA synthase | - |
| LUZ08_RS10410 | - | 2078970..2079644 (+) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| LUZ08_RS10415 | - | 2079733..2080687 (-) | 955 | Protein_2018 | replication initiation factor domain-containing protein | - |
| LUZ08_RS10420 | mobV | 2081214..2082456 (-) | 1243 | Protein_2019 | MobV family relaxase | - |
| LUZ08_RS10425 | tet(K) | 2082642..2084021 (-) | 1380 | WP_000492283.1 | tetracycline efflux MFS transporter Tet(K) | - |
| LUZ08_RS10430 | - | 2084218..2084892 (+) | 675 | WP_001106055.1 | IS6-like element IS257 family transposase | - |
| LUZ08_RS10435 | - | 2085024..2085266 (+) | 243 | WP_001803415.1 | LytTR family DNA-binding domain-containing protein | - |
| LUZ08_RS10440 | - | 2085337..2085627 (+) | 291 | WP_169301211.1 | DUF3021 domain-containing protein | - |
| LUZ08_RS10445 | - | 2086060..2086734 (+) | 675 | WP_001105999.1 | IS6-like element IS257 family transposase | - |
| LUZ08_RS10450 | - | 2086770..2087300 (+) | 531 | WP_041205518.1 | hypothetical protein | - |
| LUZ08_RS10455 | merB | 2087495..2088145 (-) | 651 | WP_000790333.1 | organomercurial lyase MerB | - |
| LUZ08_RS10460 | merA | 2088227..2089870 (-) | 1644 | WP_000193219.1 | mercury(II) reductase | - |
| LUZ08_RS10465 | - | 2089928..2090266 (-) | 339 | WP_000968575.1 | hypothetical protein | - |
| LUZ08_RS10470 | - | 2090401..2091081 (-) | 681 | WP_033842288.1 | cytochrome c biogenesis CcdA family protein | - |
| LUZ08_RS10475 | - | 2091078..2091431 (-) | 354 | WP_033842287.1 | TlpA disulfide reductase family protein | - |
| LUZ08_RS10480 | merR | 2091448..2091855 (-) | 408 | WP_000425271.1 | Hg(II)-responsive transcriptional regulator MerR | - |
| LUZ08_RS10485 | - | 2092155..2093501 (-) | 1347 | WP_000163428.1 | NAD(P)/FAD-dependent oxidoreductase | - |
| LUZ08_RS10490 | - | 2093784..2094458 (+) | 675 | WP_001105999.1 | IS6-like element IS257 family transposase | - |
| LUZ08_RS10495 | - | 2094520..2096733 (+) | 2214 | Protein_2034 | type I restriction endonuclease subunit R | - |
| LUZ08_RS10500 | - | 2096811..2097134 (-) | 324 | WP_001176049.1 | PepSY domain-containing protein | - |
| LUZ08_RS10505 | - | 2097528..2097749 (-) | 222 | WP_002504703.1 | hypothetical protein | - |
| LUZ08_RS10510 | - | 2097698..2098141 (-) | 444 | WP_000941333.1 | hypothetical protein | - |
| LUZ08_RS10515 | - | 2098203..2098730 (-) | 528 | WP_000717929.1 | hypothetical protein | - |
| LUZ08_RS10520 | - | 2098865..2099353 (-) | 489 | WP_000393586.1 | hypothetical protein | - |
| LUZ08_RS10525 | - | 2099369..2099659 (-) | 291 | WP_000065261.1 | hypothetical protein | - |
| LUZ08_RS10530 | - | 2099716..2100588 (-) | 873 | WP_000373149.1 | HTH domain-containing protein | - |
| LUZ08_RS10535 | - | 2100758..2100904 (-) | 147 | Protein_2042 | JAB domain-containing protein | - |
| LUZ08_RS10540 | - | 2101136..2101798 (-) | 663 | WP_001092058.1 | class I SAM-dependent methyltransferase | - |
| LUZ08_RS10545 | - | 2102190..2102249 (+) | 60 | WP_181875734.1 | erythromycin resistance leader peptide | - |
| LUZ08_RS10550 | erm(A) | 2102307..2103038 (+) | 732 | WP_001072197.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) | - |
| LUZ08_RS10555 | - | 2103164..2103946 (-) | 783 | WP_000067268.1 | aminoglycoside nucleotidyltransferase ANT(9)-Ia | - |
| LUZ08_RS10560 | - | 2104097..2104474 (-) | 378 | WP_000361059.1 | DUF6262 family protein | - |
| LUZ08_RS10565 | - | 2104481..2106373 (-) | 1893 | WP_001557544.1 | site-specific integrase | - |
| LUZ08_RS10570 | - | 2106370..2107455 (-) | 1086 | WP_000868132.1 | tyrosine-type recombinase/integrase | - |
| LUZ08_RS10575 | - | 2107574..2107891 (-) | 318 | WP_130825069.1 | JAB domain-containing protein | - |
| LUZ08_RS10580 | - | 2107912..2108418 (-) | 507 | WP_000849085.1 | DUF1643 domain-containing protein | - |
| LUZ08_RS10585 | - | 2108434..2108745 (-) | 312 | WP_001083108.1 | DUF960 family protein | - |
| LUZ08_RS10590 | - | 2108841..2109179 (-) | 339 | WP_000171557.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| LUZ08_RS10595 | ccrC | 2109285..2110961 (-) | 1677 | WP_000676597.1 | cassette chromosome recombinase CcrC | - |
Sequence
Protein
Download Length: 448 a.a. Molecular weight: 52138.19 Da Isoelectric Point: 10.1760
>NTDB_id=637403 LUZ08_RS10290 WP_000816499.1 2055357..2056703(+) (ccrA) [Staphylococcus aureus strain E1174_IV_ST22]
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA
Nucleotide
Download Length: 1347 bp
>NTDB_id=637403 LUZ08_RS10290 WP_000816499.1 2055357..2056703(+) (ccrA) [Staphylococcus aureus strain E1174_IV_ST22]
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus COL |
78.174 |
100 |
0.783 |
| ccrA | Staphylococcus aureus N315 |
72.383 |
100 |
0.725 |