Detailed information NTG0635347

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: LTK15_RS01405
• Genome accession: NZ_CP089154
• Coordinates: 260129..261172 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain UNC_SaCF36
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 255129..266172

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LTK15_RS01375 (LTK15_01375)	-	255809..255918 (+)	110	Protein_261	hypothetical protein	-
LTK15_RS01380 (LTK15_01380)	-	255947..256360 (+)	414	WP_001622129.1	hypothetical protein	-
LTK15_RS01385 (LTK15_01385)	-	256538..257524 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
LTK15_RS01390 (LTK15_01390)	map	258055..258813 (+)	759	WP_000636137.1	type I methionyl aminopeptidase	-
LTK15_RS01395 (LTK15_01395)	-	259030..259416 (+)	387	WP_001110184.1	hypothetical protein	-
LTK15_RS01400 (LTK15_01400)	liaF	259431..260132 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
LTK15_RS01405 (LTK15_01405)	vraS	260129..261172 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
LTK15_RS01410 (LTK15_01410)	vraR	261162..261791 (+)	630	WP_086040686.1	two-component system response regulator VraR	Regulator
LTK15_RS01415 (LTK15_01415)	-	261904..263121 (-)	1218	WP_000037083.1	YihY/virulence factor BrkB family protein	-
LTK15_RS01420 (LTK15_01420)	-	263399..263674 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
LTK15_RS01425 (LTK15_01425)	-	263681..264145 (-)	465	WP_000228668.1	low molecular weight protein-tyrosine-phosphatase	-
LTK15_RS01430 (LTK15_01430)	-	264292..264492 (+)	201	WP_000180459.1	DUF1128 family protein	-
LTK15_RS01435 (LTK15_01435)	-	264504..265751 (+)	1248	WP_232044296.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=635347 LTK15_RS01405 WP_001017131.1 260129..261172(+) (vraS) [Staphylococcus aureus strain UNC_SaCF36]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=635347 LTK15_RS01405 WP_001017131.1 260129..261172(+) (vraS) [Staphylococcus aureus strain UNC_SaCF36]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTACCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTCGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1