Detailed information NTG0633312

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: LPC11_RS04685
• Genome accession: NZ_CP088218
• Coordinates: 975599..976642 (+)
• Length: 347 a.a.
• NCBI ID: WP_002452288.1
• Uniprot ID: A0A2T4Q1J8
• Organism: Staphylococcus sp. HL28
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 970599..981642

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LPC11_RS04660 (LPC11_04660)	-	971656..972381 (+)	726	WP_023373124.1	type 1 glutamine amidotransferase	-
LPC11_RS04665 (LPC11_04665)	-	972448..973434 (-)	987	WP_023373122.1	aromatic acid exporter family protein	-
LPC11_RS04670 (LPC11_04670)	map	973601..974356 (+)	756	WP_023373120.1	type I methionyl aminopeptidase	-
LPC11_RS04675 (LPC11_04675)	-	974500..974886 (+)	387	WP_023373118.1	DUF2543 family protein	-
LPC11_RS04680 (LPC11_04680)	liaF	974901..975602 (+)	702	WP_023373116.1	cell wall-active antibiotics response protein LiaF	-
LPC11_RS04685 (LPC11_04685)	vraS	975599..976642 (+)	1044	WP_002452288.1	sensor histidine kinase	Regulator
LPC11_RS04690 (LPC11_04690)	vraR	976632..977261 (+)	630	WP_002466112.1	two-component system response regulator VraR	Regulator
LPC11_RS04695 (LPC11_04695)	-	977320..978555 (-)	1236	WP_023373114.1	YihY/virulence factor BrkB family protein	-
LPC11_RS04700 (LPC11_04700)	-	978783..979067 (-)	285	WP_002466132.1	YtxH domain-containing protein	-
LPC11_RS04705 (LPC11_04705)	-	979074..979538 (-)	465	WP_023373112.1	low molecular weight protein-tyrosine-phosphatase	-
LPC11_RS04710 (LPC11_04710)	-	979685..979888 (+)	204	WP_041613607.1	DUF1128 domain-containing protein	-
LPC11_RS04715 (LPC11_04715)	-	979901..981142 (+)	1242	WP_023373108.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40101.60 Da
• Isoelectric Point: 6.2449

>NTDB_id=633312 LPC11_RS04685 WP_002452288.1 975599..976642(+) (vraS) [Staphylococcus sp. HL28]
MNHYIRAIGSMLILIYSMLTAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNIIVILLCIIVGSVLAYKINQQNDWIKT
QIERSIEGETVGINDQNIELYSETLEIYHTLVPLNQELHRLRMKTQNLTNENYNMNDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETQLEPPLDQQIPVLEKMIQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QEFKVPKGIEDHLFRITQEAISNTLRHSNGTRVTVELFNKQDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYGD

Nucleotide

• Length: 1044 bp

>NTDB_id=633312 LPC11_RS04685 WP_002452288.1 975599..976642(+) (vraS) [Staphylococcus sp. HL28]
ATGAACCACTATATAAGAGCTATTGGGTCTATGCTGATATTGATATATAGTATGTTAACGGCGTTCTTATTTATTGATAA
AGTTTTTGTCAACATCATTTACTTTCAAGGCATGTTTTATACACAAATTTTCGGTATTCCAGTGTTCTTATTTTTAAATA
TTATAGTTATATTATTATGTATTATAGTAGGGTCAGTTTTAGCATATAAAATTAATCAACAGAATGATTGGATTAAAACT
CAAATTGAGCGATCAATTGAAGGGGAAACTGTTGGAATTAATGACCAAAATATTGAATTGTATAGCGAGACGTTGGAAAT
ATATCACACACTCGTTCCATTAAATCAAGAGTTACATCGATTAAGAATGAAAACACAAAATTTAACTAACGAAAATTATA
ATATGAATGATGTTAAAGTTAAAAAAATTATTGAAGATGAGCGACAACGCTTAGCTAGGGAATTGCATGATTCTGTAAGC
CAACAATTATTTGCAGCAAGTATGATGTTATCAGCAATAAAAGAAACACAGTTAGAACCACCATTAGATCAACAAATACC
CGTTCTTGAAAAAATGATTCAAGATTCACAACTTGAAATGAGAGCATTGTTACTTCATTTAAGACCACTAGGATTAAAAG
ATAAATCATTAGGTGAAGGTATTAAAGATTTAGTCATTGACCTTCAAAAGAAAGTACCAATGAAAGTAGTCCATGAAATC
CAAGAATTTAAAGTACCAAAAGGAATAGAAGATCATTTATTCAGAATCACACAAGAAGCAATTTCAAATACTTTGAGACA
TTCTAATGGTACAAGAGTAACGGTTGAATTATTTAATAAGCAAGATTATCTACTTTTACGTATACAAGATAATGGTAAAG
GTTTTAATGTAGATGAGAAACTTGAACAAAGCTATGGATTAAAGAATATGCGTGAACGTGCACTAGAAATTGGTGCCACA
TTCCATATCGTATCATTACCAGACTCTGGTACACGTATTGAAGTTAAAGCACCATTAAACAAGGAGGATTCGTATGGCGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase (HisKA_3) (147-210)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

3D structure

• AlphaFold DB: A0A2T4Q1J8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	94.524	100	0.945