Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   N5922_RS09610 Genome accession   NZ_CP104681
Coordinates   1993525..1994181 (+) Length   218 a.a.
NCBI ID   WP_000611328.1    Uniprot ID   P66797
Organism   Escherichia coli strain 2022CK-00450     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1988525..1999181
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  N5922_RS09580 (N5922_09575) dcyD 1989404..1990390 (+) 987 WP_001128215.1 D-cysteine desulfhydrase -
  N5922_RS09585 (N5922_09580) tcyL 1990405..1991073 (+) 669 WP_001158220.1 cystine ABC transporter permease -
  N5922_RS09590 (N5922_09585) tcyN 1991070..1991822 (+) 753 WP_001272994.1 L-cystine ABC transporter ATP-binding protein TcyN -
  N5922_RS09595 (N5922_09590) sdiA 1992052..1992774 (+) 723 WP_016242211.1 transcriptional regulator SdiA -
  N5922_RS09600 (N5922_09595) yecF 1992842..1993066 (-) 225 WP_000106474.1 DUF2594 family protein YecF -
  N5922_RS09605 (N5922_09600) yecU 1993053..1993229 (-) 177 WP_000590344.1 protein YecU -
  N5922_RS25875 - 1993267..1993383 (-) 117 WP_001302039.1 hypothetical protein -
  N5922_RS09610 (N5922_09605) letA 1993525..1994181 (+) 657 WP_000611328.1 UvrY/SirA/GacA family response regulator transcription factor Regulator
  N5922_RS09615 (N5922_09610) uvrC 1994178..1996010 (+) 1833 WP_001283424.1 excinuclease ABC subunit UvrC Machinery gene
  N5922_RS09620 (N5922_09615) pgsA 1996067..1996615 (+) 549 WP_001160187.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
  N5922_RS09640 (N5922_09635) - 1997310..1998050 (-) 741 WP_001742934.1 hypothetical protein -
  N5922_RS09645 (N5922_09640) - 1998131..1999141 (+) 1011 WP_016242210.1 site-specific integrase -

Sequence

Protein


Download         Length: 218 a.a.        Molecular weight: 23862.63 Da        Isoelectric Point: 6.9614

>NTDB_id=632374 N5922_RS09610 WP_000611328.1 1993525..1994181(+) (letA) [Escherichia coli strain 2022CK-00450]
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRANAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ

Nucleotide


Download         Length: 657 bp        

>NTDB_id=632374 N5922_RS09610 WP_000611328.1 1993525..1994181(+) (letA) [Escherichia coli strain 2022CK-00450]
TTGATCAACGTTCTACTTGTTGATGACCACGAACTGGTGCGCGCAGGGATACGACGCATTCTGGAAGATATAAAGGGTAT
AAAAGTCGTCGGTGAGGCATCGTGCGGTGAAGACGCCGTTAAGTGGTGTCGGGCAAATGCCGTTGACGTGGTGCTAATGG
ACATGAGTATGCCGGGCATTGGCGGTCTTGAGGCGACGCGTAAAATCGCGCGTTCCACAGCTGATGTCAAAATCATCATG
CTTACCGTCCATACAGAAAACCCTTTACCAGCGAAAGTCATGCAGGCCGGTGCTGCGGGCTACCTCAGCAAAGGCGCGGC
TCCGCAGGAAGTCGTGAGTGCGATTCGTTCTGTCTATTCAGGGCAGCGTTACATTGCTTCTGACATCGCTCAACAAATGG
CGTTAAGCCAGATCGAACCAGAAAAAACAGAAAGCCCATTTGCCAGTTTGTCTGAACGTGAATTGCAGATTATGCTGATG
ATCACCAAGGGCCAGAAGGTCAATGAGATCTCAGAACAGCTCAATCTCAGTCCGAAAACGGTGAACAGCTACCGCTATCG
TATGTTCAGTAAACTAAACATTCATGGCGATGTTGAGCTGACTCACCTGGCAATTCGCCATGGTCTGTGTAATGCGGAGA
CATTATCAAGTCAGTGA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(149-204)

Response regulator receiver domain (Response_reg)

(4-115)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P66797

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

50.725

94.954

0.482
  letA Legionella pneumophila strain ERS1305867

50.725

94.954

0.482