Detailed information    

insolico Bioinformatically predicted

Overview


Name   agrA   Type   Regulator
Locus tag   LK342_RS09790 Genome accession   NZ_CP086574
Coordinates   2040002..2040718 (+) Length   238 a.a.
NCBI ID   WP_000688486.1    Uniprot ID   A0A7U7PWL0
Organism   Staphylococcus argenteus strain RIVM_M046968     
Function   promote expression of competence genes (predicted from homology)   
Competence regulation

Related MGE


Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 2010716..2061676 2040002..2040718 within 0


Gene organization within MGE regions


Location: 2010716..2061676
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  LK342_RS09615 (LK342_09615) ssbA 2011409..2011879 (-) 471 WP_047437043.1 single-stranded DNA-binding protein Machinery gene
  LK342_RS09620 (LK342_09620) - 2011880..2012497 (-) 618 WP_071621397.1 MBL fold metallo-hydrolase -
  LK342_RS09625 (LK342_09625) - 2012578..2013498 (-) 921 WP_000138475.1 recombinase RecT -
  LK342_RS09630 (LK342_09630) - 2013500..2015443 (-) 1944 WP_047437048.1 AAA family ATPase -
  LK342_RS09635 (LK342_09635) - 2015452..2015715 (-) 264 WP_072292182.1 hypothetical protein -
  LK342_RS09640 (LK342_09640) - 2015724..2015984 (-) 261 WP_047437050.1 DUF1108 family protein -
  LK342_RS09645 (LK342_09645) - 2015989..2016291 (-) 303 WP_047437053.1 DUF2482 family protein -
  LK342_RS09650 (LK342_09650) - 2016386..2016547 (-) 162 WP_000066011.1 DUF1270 domain-containing protein -
  LK342_RS09655 (LK342_09655) - 2016544..2016864 (-) 321 WP_001120197.1 DUF771 domain-containing protein -
  LK342_RS09660 (LK342_09660) - 2016924..2017298 (+) 375 WP_047437056.1 hypothetical protein -
  LK342_RS09665 (LK342_09665) - 2017303..2017497 (-) 195 WP_047437059.1 hypothetical protein -
  LK342_RS09670 (LK342_09670) - 2017754..2017936 (-) 183 WP_072292181.1 hypothetical protein -
  LK342_RS09675 (LK342_09675) - 2018080..2018829 (-) 750 WP_047437065.1 phage antirepressor KilAC domain-containing protein -
  LK342_RS09680 (LK342_09680) - 2018846..2019115 (-) 270 WP_047432554.1 helix-turn-helix transcriptional regulator -
  LK342_RS09685 (LK342_09685) - 2019134..2019287 (-) 154 Protein_1875 transcriptional regulator -
  LK342_RS09690 (LK342_09690) - 2019250..2019963 (+) 714 WP_031768797.1 XRE family transcriptional regulator -
  LK342_RS09695 (LK342_09695) - 2019981..2020595 (+) 615 WP_047437068.1 hypothetical protein -
  LK342_RS09700 (LK342_09700) - 2020790..2020957 (+) 168 WP_047437071.1 hypothetical protein -
  LK342_RS09705 (LK342_09705) - 2021237..2022328 (+) 1092 WP_230582822.1 Abi family protein -
  LK342_RS09710 (LK342_09710) - 2022388..2023425 (+) 1038 WP_000857198.1 site-specific integrase -
  LK342_RS09715 (LK342_09715) sph 2023476..2024306 (+) 831 Protein_1881 sphingomyelin phosphodiesterase -
  LK342_RS09720 (LK342_09720) - 2024930..2025946 (-) 1017 WP_047528390.1 leukocidin/hemolysin toxin family protein -
  LK342_RS09725 (LK342_09725) - 2025968..2027023 (-) 1056 WP_047528391.1 leukocidin/hemolysin toxin family protein -
  LK342_RS09730 (LK342_09730) - 2027450..2028673 (+) 1224 WP_047528392.1 ArgE/DapE family deacylase -
  LK342_RS09735 (LK342_09735) - 2029281..2030588 (+) 1308 WP_047528393.1 TrkH family potassium uptake protein -
  LK342_RS09740 (LK342_09740) groL 2031180..2032796 (-) 1617 WP_001118817.1 chaperonin GroEL -
  LK342_RS09745 (LK342_09745) groES 2032872..2033156 (-) 285 WP_000917289.1 co-chaperone GroES -
  LK342_RS09750 (LK342_09750) mroQ 2033333..2034076 (+) 744 WP_047528396.1 CPBP family intramembrane glutamic endopeptidase MroQ -
  LK342_RS09755 (LK342_09755) - 2034102..2035361 (-) 1260 WP_047528397.1 SdrH family protein -
  LK342_RS09760 (LK342_09760) - 2035557..2036183 (+) 627 WP_047437110.1 nitroreductase family protein -
  LK342_RS09765 (LK342_09765) - 2036284..2037069 (+) 786 WP_047528398.1 carbon-nitrogen family hydrolase -
  LK342_RS13405 (LK342_09770) - 2037589..2037723 (-) 135 WP_001823225.1 delta-lysin family phenol-soluble modulin -
  LK342_RS09775 (LK342_09775) - 2037959..2038522 (+) 564 WP_047437114.1 accessory gene regulator AgrB -
  LK342_RS09780 (LK342_09780) - 2038526..2038666 (+) 141 WP_047437117.1 cyclic lactone autoinducer peptide -
  LK342_RS09785 (LK342_09785) - 2038691..2039983 (+) 1293 WP_047528400.1 GHKL domain-containing protein -
  LK342_RS09790 (LK342_09790) agrA 2040002..2040718 (+) 717 WP_000688486.1 LytTR family DNA-binding domain-containing protein Regulator
  LK342_RS09795 (LK342_09795) - 2041071..2042030 (-) 960 WP_047528401.1 carbohydrate kinase -
  LK342_RS09800 (LK342_09800) - 2042027..2043511 (-) 1485 WP_000141408.1 sucrose-6-phosphate hydrolase -
  LK342_RS09805 (LK342_09805) - 2043660..2044610 (-) 951 WP_047528402.1 LacI family DNA-binding transcriptional regulator -
  LK342_RS09810 (LK342_09810) - 2044782..2046032 (-) 1251 WP_001052255.1 ammonium transporter -
  LK342_RS09815 (LK342_09815) - 2046247..2046471 (-) 225 WP_047528404.1 sulfurtransferase TusA family protein -
  LK342_RS09820 (LK342_09820) - 2046546..2047628 (-) 1083 WP_047528406.1 YeeE/YedE family protein -
  LK342_RS09825 (LK342_09825) - 2047927..2048562 (-) 636 WP_001283609.1 redox-sensing transcriptional repressor Rex -
  LK342_RS09830 (LK342_09830) - 2048816..2050744 (+) 1929 WP_047528407.1 ABC-F family ATP-binding cassette domain-containing protein -
  LK342_RS09835 (LK342_09835) - 2051106..2052716 (+) 1611 WP_250340822.1 MutS family DNA mismatch repair protein -
  LK342_RS09840 (LK342_09840) tsaD 2052817..2053842 (-) 1026 WP_031787868.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD -
  LK342_RS09845 (LK342_09845) rimI 2053835..2054299 (-) 465 WP_000372752.1 ribosomal protein S18-alanine N-acetyltransferase -
  LK342_RS09850 (LK342_09850) tsaB 2054272..2054934 (-) 663 WP_047432522.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB -
  LK342_RS09855 (LK342_09855) tsaE 2054915..2055376 (-) 462 WP_031787870.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
  LK342_RS09860 (LK342_09860) - 2055413..2055562 (+) 150 WP_031787871.1 hypothetical protein -
  LK342_RS09865 (LK342_09865) ilvD 2055894..2057582 (+) 1689 WP_001255776.1 dihydroxy-acid dehydratase -
  LK342_RS09870 (LK342_09870) ilvB 2057600..2059369 (+) 1770 WP_014373872.1 biosynthetic-type acetolactate synthase large subunit -
  LK342_RS09875 (LK342_09875) - 2059369..2059623 (+) 255 WP_000196758.1 ACT domain-containing protein -
  LK342_RS09880 (LK342_09880) ilvC 2059762..2060766 (+) 1005 WP_000214558.1 ketol-acid reductoisomerase -

Sequence


Protein


Download         Length: 238 a.a.        Molecular weight: 27894.87 Da        Isoelectric Point: 5.8625

>NTDB_id=625599 LK342_RS09790 WP_000688486.1 2040002..2040718(+) (agrA) [Staphylococcus argenteus strain RIVM_M046968]
MKIFICEDDPKQRENMVTIIKNYIMIEEKPMEIALATDDPYEVLEQSKNMNDIGCYFLDIQLSTDINGIKLGSEIRKHDP
VGNIIFVTSHSELTYLTFVYKVAAMDFIFKDDPAELKTRIIDCLETAHTRLQLLSKDNSVETIELKRGSNSVYVQYDDIM
FFESSTKSHRLIAHLDNRQIEFYGNLKELSQLDDRFFRCHNSFVVNRHNIESIDSKERIVYFKNKEHCYASVRNVKKI

Nucleotide


Download         Length: 717 bp        

>NTDB_id=625599 LK342_RS09790 WP_000688486.1 2040002..2040718(+) (agrA) [Staphylococcus argenteus strain RIVM_M046968]
ATGAAAATTTTCATTTGCGAAGACGATCCAAAACAAAGAGAAAACATGGTTACCATTATTAAAAATTATATAATGATAGA
AGAAAAACCTATGGAAATTGCCCTCGCAACTGATGATCCTTATGAGGTGCTTGAGCAATCTAAAAATATGAATGATATAG
GTTGTTACTTTTTAGATATTCAACTTTCAACAGACATTAATGGTATTAAATTAGGTAGTGAAATACGTAAGCATGACCCT
GTTGGCAATATAATATTTGTTACTAGTCATAGTGAACTTACTTATTTAACATTTGTCTACAAAGTTGCAGCAATGGATTT
TATTTTTAAAGATGATCCTGCTGAATTAAAAACACGAATTATAGATTGTCTAGAAACTGCACATACACGCTTACAATTAT
TATCAAAAGATAATAGCGTTGAAACGATAGAGTTAAAACGTGGCAGTAATTCAGTGTATGTTCAATACGATGATATTATG
TTTTTCGAATCATCTACCAAATCGCATAGACTCATCGCCCATTTAGATAATCGTCAAATTGAATTTTATGGTAATTTAAA
AGAATTGAGTCAATTAGATGATCGTTTTTTCAGATGTCATAATAGTTTTGTTGTCAATCGTCATAATATCGAATCCATTG
ATTCGAAAGAACGAATTGTCTATTTTAAAAATAAAGAACATTGTTATGCATCGGTAAGAAACGTTAAAAAAATATAA


Secondary structure


Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure


Source ID Structure
  AlphaFold DB A0A7U7PWL0

Transmembrane helices


Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.



Visualization of predicted probability:


Similar proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  agrA Staphylococcus aureus N315

98.739

100

0.987