Detailed information NTG0625516

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: LK336_RS00420
• Genome accession: NZ_CP086572
• Coordinates: 79102..80145 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus argenteus strain RIVM_M036020
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 74102..85145

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LK336_RS00395 (LK336_00395)	-	74153..74875 (+)	723	WP_031787877.1	type 1 glutamine amidotransferase	-
LK336_RS00400 (LK336_00400)	-	75507..76493 (-)	987	WP_031788370.1	aromatic acid exporter family protein	-
LK336_RS00405 (LK336_00405)	map	77024..77782 (+)	759	WP_031788218.1	type I methionyl aminopeptidase	-
LK336_RS00410 (LK336_00410)	-	78003..78389 (+)	387	WP_001110170.1	hypothetical protein	-
LK336_RS00415 (LK336_00415)	liaF	78404..79105 (+)	702	WP_031788217.1	cell wall-active antibiotics response protein LiaF	-
LK336_RS00420 (LK336_00420)	vraS	79102..80145 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
LK336_RS00425 (LK336_00425)	vraR	80135..80764 (+)	630	WP_000153529.1	two-component system response regulator VraR	Regulator
LK336_RS00430 (LK336_00430)	-	80880..82103 (-)	1224	WP_000037065.1	YihY/virulence factor BrkB family protein	-
LK336_RS00435 (LK336_00435)	-	82382..82657 (-)	276	WP_000428174.1	YtxH domain-containing protein	-
LK336_RS00440 (LK336_00440)	-	82664..83128 (-)	465	WP_000228669.1	low molecular weight protein-tyrosine-phosphatase	-
LK336_RS00445 (LK336_00445)	-	83275..83475 (+)	201	WP_000180459.1	DUF1128 family protein	-
LK336_RS00450 (LK336_00450)	-	83487..84734 (+)	1248	WP_000656301.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=625516 LK336_RS00420 WP_001017131.1 79102..80145(+) (vraS) [Staphylococcus argenteus strain RIVM_M036020]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=625516 LK336_RS00420 WP_001017131.1 79102..80145(+) (vraS) [Staphylococcus argenteus strain RIVM_M036020]
ATGAACCATTATATTAGAACAATTGGTTCGATGCTCATCTTAGTATACAGCATGCTAGCGGCATTTCTTTTTATAGATAA
AGTTTTCGTTAATATTATTTATTTTCAAGGCATGTTTTATACACAAATATTTGGGATTCCAGTCTTTTTATTTTTAAATC
TCATTATCATTTTATTGTGTATCATCGTCGGATCGGTGCTTGCCTACAAAATTAATCAACAAAATGATTGGATTAAGACA
CAAATTGAGCGTTCTATGGAAGGCGAAACAGTAGGTATCAATGATCAAAATATAGAAATATATAGTGAAACATTAGATTT
ATATCATACGTTAGTACCTTTAAATCAAGAATTGCATAAGTTAAGACTCAAAACGCAAAATTTAACAAATGAAAATTACA
ATATTAATGATGTTAAAGTTAAAAAGATTATCGAAGATGAAAGACAACGTTTAGCTAGAGAACTACACGACTCTGTTAGT
CAACAACTTTTTGCGGCAAGTATGATGTTATCTGCAATTAAAGAAACGAAATTAGAACCACCTTTAGATCAACAAATACC
TATTTTAGAGAAAATGGTTCAAGATTCTCAGTTAGAAATGCGTGCTTTGCTGCTACACTTAAGACCACTCGGCTTGAAAG
ATAAGTCATTAGGCGAAGGTATTAAAGATTTAGTTATTGATTTACAAAAGAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCAAAAGGTATTGAAGATCATTTATTTAGAATTACGCAAGAAGCAATATCTAATACATTGAGACA
TTCAAATGGTACGAAAGTAACTGTAGAATTATTTAATAAAGATGATTATTTATTGTTAAGGATACAAGATAATGGTAAAG
GTTTTAATGTAGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCACTACCAGATTCAGGTACACGTATTGAGGTGAAAGCACCTCTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1