Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   M5S53_RS09970 Genome accession   NZ_CP103592
Coordinates   2092940..2093596 (+) Length   218 a.a.
NCBI ID   WP_000611328.1    Uniprot ID   P66797
Organism   Escherichia coli O25b:H4-ST131 strain 4224     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2087940..2098596
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  M5S53_RS09940 (M5S53_09940) dcyD 2088819..2089805 (+) 987 WP_001128232.1 D-cysteine desulfhydrase -
  M5S53_RS09945 (M5S53_09945) tcyL 2089820..2090488 (+) 669 WP_001158220.1 cystine ABC transporter permease -
  M5S53_RS09950 (M5S53_09950) tcyN 2090485..2091237 (+) 753 WP_001273000.1 L-cystine ABC transporter ATP-binding protein TcyN -
  M5S53_RS09955 (M5S53_09955) sdiA 2091467..2092189 (+) 723 WP_001154255.1 transcriptional regulator SdiA -
  M5S53_RS09960 (M5S53_09960) yecF 2092257..2092481 (-) 225 WP_000106474.1 DUF2594 family protein YecF -
  M5S53_RS09965 (M5S53_09965) yecU 2092468..2092644 (-) 177 WP_001307856.1 protein YecU -
  M5S53_RS09970 (M5S53_09970) letA 2092940..2093596 (+) 657 WP_000611328.1 UvrY/SirA/GacA family response regulator transcription factor Regulator
  M5S53_RS09975 (M5S53_09975) uvrC 2093593..2095425 (+) 1833 WP_001283421.1 excinuclease ABC subunit UvrC Machinery gene
  M5S53_RS09980 (M5S53_09980) pgsA 2095482..2096030 (+) 549 WP_001160187.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
  M5S53_RS10000 (M5S53_10000) - 2096614..2097630 (-) 1017 WP_001531780.1 tyrosine-type recombinase/integrase -
  M5S53_RS10005 (M5S53_10005) - 2097599..2097862 (-) 264 WP_000833838.1 DUF4224 domain-containing protein -
  M5S53_RS10015 (M5S53_10015) - 2098072..2098254 (-) 183 WP_000916334.1 hypothetical protein -

Sequence

Protein


Download         Length: 218 a.a.        Molecular weight: 23862.63 Da        Isoelectric Point: 6.9614

>NTDB_id=623473 M5S53_RS09970 WP_000611328.1 2092940..2093596(+) (letA) [Escherichia coli O25b:H4-ST131 strain 4224]
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRANAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ

Nucleotide


Download         Length: 657 bp        

>NTDB_id=623473 M5S53_RS09970 WP_000611328.1 2092940..2093596(+) (letA) [Escherichia coli O25b:H4-ST131 strain 4224]
TTGATCAACGTTCTACTTGTTGATGACCACGAACTGGTGCGCGCAGGGATACGACGCATTCTGGAAGATATAAAGGGTAT
AAAAGTCGTCGGTGAGGCATCGTGCGGTGAAGACGCCGTTAAATGGTGCCGGGCAAATGCCGTTGACGTGGTGCTAATGG
ACATGAGTATGCCGGGCATTGGCGGTCTTGAGGCGACGCGTAAAATCGCGCGTTCCACAGCTGATGTCAAAATCATCATG
CTTACCGTCCATACAGAAAACCCTTTACCAGCGAAAGTCATGCAGGCCGGAGCTGCGGGCTACCTCAGCAAAGGCGCGGC
TCCGCAGGAAGTCGTGAGTGCGATTCGTTCTGTCTATTCAGGGCAGCGTTACATTGCTTCTGATATCGCTCAACAAATGG
CGTTAAGCCAGATCGAACCAGAAAAAACAGAAAGCCCATTTGCCAGTTTGTCTGAACGTGAATTGCAGATTATGCTGATG
ATCACCAAGGGCCAGAAGGTCAATGAGATCTCAGAACAGCTCAATCTCAGTCCGAAAACGGTGAACAGCTACCGCTATCG
TATGTTCAGTAAACTAAACATTCATGGCGATGTTGAGCTGACTCACCTGGCAATTCGCCATGGTCTGTGTAATGCGGAGA
CATTATCAAGTCAGTGA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(149-204)

Response regulator receiver domain (Response_reg)

(4-115)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P66797

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

50.725

94.954

0.482
  letA Legionella pneumophila strain ERS1305867

50.725

94.954

0.482