Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   M5T00_RS10690 Genome accession   NZ_CP103589
Coordinates   2262604..2263260 (+) Length   218 a.a.
NCBI ID   WP_000611328.1    Uniprot ID   P66797
Organism   Escherichia coli strain 4750     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2257604..2268260
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  M5T00_RS10660 (M5T00_10660) dcyD 2258483..2259469 (+) 987 WP_001128237.1 D-cysteine desulfhydrase -
  M5T00_RS10665 (M5T00_10665) tcyL 2259484..2260152 (+) 669 WP_001158220.1 cystine ABC transporter permease -
  M5T00_RS10670 (M5T00_10670) tcyN 2260149..2260901 (+) 753 WP_001273000.1 L-cystine ABC transporter ATP-binding protein TcyN -
  M5T00_RS10675 (M5T00_10675) sdiA 2261131..2261853 (+) 723 WP_001154255.1 transcriptional regulator SdiA -
  M5T00_RS10680 (M5T00_10680) yecF 2261921..2262145 (-) 225 WP_000106474.1 DUF2594 family protein YecF -
  M5T00_RS10685 (M5T00_10685) yecU 2262132..2262308 (-) 177 WP_001307856.1 protein YecU -
  M5T00_RS10690 (M5T00_10690) letA 2262604..2263260 (+) 657 WP_000611328.1 UvrY/SirA/GacA family response regulator transcription factor Regulator
  M5T00_RS10695 (M5T00_10695) uvrC 2263257..2265089 (+) 1833 WP_001773939.1 excinuclease ABC subunit UvrC Machinery gene
  M5T00_RS10700 (M5T00_10700) pgsA 2265146..2265694 (+) 549 WP_001538881.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
  M5T00_RS10720 (M5T00_10720) yecA 2266343..2267008 (+) 666 WP_000847877.1 UPF0149 family protein YecA -

Sequence

Protein


Download         Length: 218 a.a.        Molecular weight: 23862.63 Da        Isoelectric Point: 6.9614

>NTDB_id=623385 M5T00_RS10690 WP_000611328.1 2262604..2263260(+) (letA) [Escherichia coli strain 4750]
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRANAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ

Nucleotide


Download         Length: 657 bp        

>NTDB_id=623385 M5T00_RS10690 WP_000611328.1 2262604..2263260(+) (letA) [Escherichia coli strain 4750]
TTGATCAACGTTCTACTTGTTGATGACCACGAACTGGTGCGCGCAGGGATACGACGCATTCTGGAAGATATAAAGGGTAT
AAAAGTCGTCGGTGAGGCATCGTGCGGTGAAGACGCCGTTAAATGGTGCCGGGCAAATGCCGTTGACGTGGTGCTAATGG
ACATGAGTATGCCGGGCATTGGCGGTCTTGAGGCGACGCGTAAAATCGCGCGTTCCACAGCTGATGTCAAAATCATCATG
CTTACCGTCCATACAGAAAACCCTTTACCAGCGAAAGTCATGCAGGCCGGAGCTGCGGGCTACCTCAGCAAAGGCGCGGC
TCCGCAGGAAGTCGTTAGTGCGATTCGTTCTGTCTATTCAGGGCAGCGTTACATTGCTTCTGATATCGCTCAACAAATGG
CGTTAAGCCAGATCGAACCAGAAAAAACAGAAAGCCCATTTGCCAGTTTGTCTGAACGTGAATTGCAGATTATGCTGATG
ATCACCAAGGGCCAGAAGGTCAATGAGATCTCAGAACAGCTCAATCTCAGTCCGAAAACGGTGAACAGCTACCGCTATCG
TATGTTCAGTAAACTAAACATTCATGGCGATGTTGAGCTGACTCACCTGGCAATTCGCCATGGTCTGTGTAATGCGGAGA
CATTATCAAGTCAGTGA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(149-204)

Response regulator receiver domain (Response_reg)

(4-115)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P66797

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

50.725

94.954

0.482
  letA Legionella pneumophila strain ERS1305867

50.725

94.954

0.482