Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   M5R24_RS10225 Genome accession   NZ_CP103562
Coordinates   2134696..2135352 (+) Length   218 a.a.
NCBI ID   WP_000611328.1    Uniprot ID   P66797
Organism   Escherichia coli O25b:H4-ST131 strain 751     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2129696..2140352
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  M5R24_RS10195 (M5R24_10195) dcyD 2130575..2131561 (+) 987 WP_001128232.1 D-cysteine desulfhydrase -
  M5R24_RS10200 (M5R24_10200) tcyL 2131576..2132244 (+) 669 WP_001158220.1 cystine ABC transporter permease -
  M5R24_RS10205 (M5R24_10205) tcyN 2132241..2132993 (+) 753 WP_001273000.1 L-cystine ABC transporter ATP-binding protein TcyN -
  M5R24_RS10210 (M5R24_10210) sdiA 2133223..2133945 (+) 723 WP_001154255.1 transcriptional regulator SdiA -
  M5R24_RS10215 (M5R24_10215) yecF 2134013..2134237 (-) 225 WP_000106474.1 DUF2594 family protein YecF -
  M5R24_RS10220 (M5R24_10220) yecU 2134224..2134400 (-) 177 WP_205849389.1 protein YecU -
  M5R24_RS10225 (M5R24_10225) letA 2134696..2135352 (+) 657 WP_000611328.1 UvrY/SirA/GacA family response regulator transcription factor Regulator
  M5R24_RS10230 (M5R24_10230) uvrC 2135349..2137181 (+) 1833 WP_001283421.1 excinuclease ABC subunit UvrC Machinery gene
  M5R24_RS10235 (M5R24_10235) pgsA 2137238..2137786 (+) 549 WP_001160187.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
  M5R24_RS10255 (M5R24_10255) - 2138370..2139386 (-) 1017 WP_001531780.1 tyrosine-type recombinase/integrase -
  M5R24_RS10260 (M5R24_10260) - 2139355..2139558 (-) 204 WP_252146624.1 DUF4224 domain-containing protein -

Sequence

Protein


Download         Length: 218 a.a.        Molecular weight: 23862.63 Da        Isoelectric Point: 6.9614

>NTDB_id=623218 M5R24_RS10225 WP_000611328.1 2134696..2135352(+) (letA) [Escherichia coli O25b:H4-ST131 strain 751]
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRANAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ

Nucleotide


Download         Length: 657 bp        

>NTDB_id=623218 M5R24_RS10225 WP_000611328.1 2134696..2135352(+) (letA) [Escherichia coli O25b:H4-ST131 strain 751]
TTGATCAACGTTCTACTTGTTGATGACCACGAACTGGTGCGCGCAGGGATACGACGCATTCTGGAAGATATAAAGGGTAT
AAAAGTCGTCGGTGAGGCATCGTGCGGTGAAGACGCCGTTAAATGGTGCCGGGCAAATGCCGTTGACGTGGTGCTAATGG
ACATGAGTATGCCGGGCATTGGCGGTCTTGAGGCGACGCGTAAAATCGCGCGTTCCACAGCTGATGTCAAAATCATCATG
CTTACCGTCCATACAGAAAACCCTTTACCAGCGAAAGTCATGCAGGCCGGAGCTGCGGGCTACCTCAGCAAAGGCGCGGC
TCCGCAGGAAGTCGTGAGTGCGATTCGTTCTGTCTATTCAGGGCAGCGTTACATTGCTTCTGATATCGCTCAACAAATGG
CGTTAAGCCAGATCGAACCAGAAAAAACAGAAAGCCCATTTGCCAGTTTGTCTGAACGTGAATTGCAGATTATGCTGATG
ATCACCAAGGGCCAGAAGGTCAATGAGATCTCAGAACAGCTCAATCTCAGTCCGAAAACGGTGAACAGCTACCGCTATCG
TATGTTCAGTAAACTAAACATTCATGGCGATGTTGAGCTGACTCACCTGGCAATTCGCCATGGTCTGTGTAATGCGGAGA
CATTATCAAGTCAGTGA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(149-204)

Response regulator receiver domain (Response_reg)

(4-115)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P66797

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

50.725

94.954

0.482
  letA Legionella pneumophila strain ERS1305867

50.725

94.954

0.482