Detailed information NTG0062267

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: KW2_RS02975
• Genome accession: NC_022369
• Coordinates: 586492..588942 (+)
• Length: 816 a.a.
• NCBI ID: WP_021036842.1
• Uniprot ID: -
• Organism: Lactococcus cremoris subsp. cremoris KW2
• Function: degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 581492..593942

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KW2_RS02950 (kw2_0592)	-	582254..582766 (+)	513	WP_011834623.1	adenine phosphoribosyltransferase	-
KW2_RS02955 (kw2_0593)	rpoE	582983..583546 (+)	564	WP_015082149.1	DNA-directed RNA polymerase subunit delta	-
KW2_RS02960 (kw2_0594)	mltG	583682..585322 (+)	1641	WP_041168579.1	endolytic transglycosylase MltG	-
KW2_RS02965 (kw2_0595)	greA	585383..585853 (+)	471	WP_011834626.1	transcription elongation factor GreA	-
KW2_RS02970 (kw2_0596)	-	586047..586502 (+)	456	WP_011834627.1	CtsR family transcriptional regulator	-
KW2_RS02975 (kw2_0597)	clpC	586492..588942 (+)	2451	WP_021036842.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
KW2_RS02980 (kw2_0598)	hpf	589077..589634 (+)	558	WP_011834629.1	ribosome hibernation-promoting factor, HPF/YfiA family	-
KW2_RS02985 (kw2_0599)	eno	589822..591123 (+)	1302	WP_010905473.1	surface-displayed alpha-enolase	-
KW2_RS02990 (kw2_0600)	-	591228..591899 (-)	672	WP_011834634.1	ABC transporter ATP-binding protein	-
KW2_RS02995 (kw2_0601)	-	591901..592974 (-)	1074	WP_021036843.1	ABC transporter permease	-
KW2_RS03000 (kw2_0602)	-	592986..593555 (-)	570	WP_021036844.1	TetR/AcrR family transcriptional regulator	-

Sequence

Protein

• Length: 816 a.a.
• Molecular weight: 90336.70 Da
• Isoelectric Point: 6.6284

>NTDB_id=62267 KW2_RS02975 WP_021036842.1 586492..588942(+) (clpC) [Lactococcus cremoris subsp. cremoris KW2]
MKFENVKYTPTLDRIFEKAAEYAHQYQYGTIESAHLLAAMATTSGSIAYSILAGMNVDSSDLLIDLEDLSSHVKVKRSEL
RFSPRAEEVVTVASFLAVHNNAEAVGTEHLLYALLQVEDGFGLQLLKLQKINIVSLRKEIEKRTGLKVPENKKAVTPMSK
RKMAKGVAENSSTPTLDSVSSDLTEAARSGKLDPMIGREAEVDRLIHILSRRTKNNPVLVGEPGVGKSAIIEGLAQRIVN
GQVPIGLMNSRIMALNMATVVAGTKFRGEFEDRLTAIVEEVSADPDVIIFIDELHTIIGAGGGMDSVNDAANILKPALAR
GDFQMVGATTYHEYQKYIEKDEALERRLARINVDEPSSDEAIAILQGLREKFEDYHQVKFTDQAIKSAVTLSVRYMTSRK
LPDKAIDLLDEAAAAVKISVKNQETKRLELEKDLVKAQEELAEAVIKLDVKASRIKEKAVEKISDKIYKFSIKEEKRQEV
TDQAVIAVASTLTGVPITQMTKSESDRLINLEKELHKRVVGQEEAISAVSRAIRRARSGVADSRRPMGSFMFLGPTGVGK
TELAKALADSVFGSEDNMIRVDMSEFMEKHSTSRLIGAPPGYVGYDEGGQLTERVRNKPYSVVLLDEVEKAHPDVFNIML
QILDDGFVTDTKGRKVDFRNTIIIMTSNLGATALRDDKTVGFGAKNITADYSAMQSRILEELKRHYRPEFLNRIDENIVF
HSLESQEIEQIVKIMSKSLIKRLAEQDIHVKLTPSAIKLIAEVGFDPEYGARPLRKALQKEVEDLLSEQLLSGEIKAGNH
ISIGASNKKIKIAQIV

Nucleotide

• Length: 2451 bp

>NTDB_id=62267 KW2_RS02975 WP_021036842.1 586492..588942(+) (clpC) [Lactococcus cremoris subsp. cremoris KW2]
ATGAAATTTGAAAATGTAAAATATACACCAACGCTGGACCGAATTTTCGAGAAAGCAGCAGAATATGCCCACCAATATCA
ATACGGTACGATTGAAAGTGCTCATTTATTGGCAGCAATGGCTACTACTTCAGGCTCAATTGCTTACAGTATTCTTGCTG
GAATGAATGTTGATTCTTCAGACTTACTGATTGATTTGGAAGATTTATCTAGCCATGTCAAAGTGAAACGTTCTGAATTG
CGTTTCTCTCCTCGCGCAGAAGAAGTGGTTACTGTAGCTAGCTTTTTAGCTGTTCATAATAATGCAGAAGCAGTAGGAAC
AGAGCATTTGCTTTATGCATTACTTCAAGTCGAAGATGGTTTTGGTCTTCAACTTTTGAAGTTACAAAAAATCAACATTG
TTTCTTTGCGAAAAGAAATTGAAAAAAGAACAGGACTTAAAGTTCCAGAAAACAAAAAAGCTGTAACACCAATGTCCAAA
CGTAAGATGGCAAAAGGGGTAGCAGAGAATTCAAGTACACCAACTTTGGATTCAGTTTCTTCAGATTTAACTGAAGCTGC
TCGTTCAGGAAAGCTTGACCCAATGATTGGTCGGGAAGCAGAAGTTGACCGTTTGATTCATATTCTTAGTCGTAGAACAA
AAAATAACCCTGTTTTAGTTGGCGAACCTGGTGTTGGTAAATCAGCAATAATCGAGGGATTGGCTCAAAGAATTGTCAAC
GGCCAAGTACCTATCGGTTTGATGAATAGCCGGATTATGGCCCTAAATATGGCAACTGTTGTTGCTGGTACAAAATTTAG
AGGTGAATTTGAAGACCGCTTGACAGCAATTGTTGAAGAAGTAAGTGCTGACCCAGATGTCATCATTTTCATTGATGAAT
TGCATACAATTATTGGTGCTGGCGGGGGCATGGACTCGGTCAATGATGCAGCAAATATTTTAAAACCAGCCCTTGCACGT
GGTGATTTTCAAATGGTTGGGGCAACGACTTATCATGAATACCAAAAATACATTGAAAAAGATGAAGCGTTAGAACGTCG
TTTGGCAAGAATCAATGTTGATGAGCCAAGTTCAGATGAAGCCATTGCTATCCTACAAGGGTTACGTGAGAAATTTGAAG
ATTATCATCAAGTAAAATTTACTGACCAAGCGATTAAAAGCGCTGTGACACTTAGTGTTCGGTACATGACCAGTCGCAAA
TTGCCTGATAAAGCCATCGACTTGCTTGATGAAGCAGCGGCAGCAGTTAAAATTTCTGTTAAAAACCAAGAAACAAAACG
TCTTGAATTAGAGAAAGACTTAGTTAAAGCTCAAGAAGAACTAGCGGAAGCTGTCATTAAACTTGATGTTAAAGCCTCTC
GCATCAAAGAAAAAGCTGTTGAAAAAATTTCTGACAAGATTTATAAATTCTCAATAAAAGAGGAAAAACGTCAAGAAGTT
ACTGACCAAGCTGTTATTGCTGTTGCCTCAACGCTGACAGGTGTTCCAATTACTCAAATGACTAAATCTGAAAGCGACCG
TTTGATTAATCTTGAAAAAGAATTGCACAAACGGGTCGTTGGTCAAGAAGAAGCAATTTCTGCGGTTTCAAGAGCCATTC
GTCGGGCACGTTCTGGTGTGGCTGATAGTCGCCGTCCAATGGGTTCATTTATGTTTCTTGGACCAACTGGTGTTGGGAAA
ACTGAGTTAGCTAAGGCCTTGGCCGATAGTGTTTTTGGTAGCGAAGACAACATGATTCGAGTGGACATGAGTGAATTCAT
GGAAAAACATTCAACTTCACGCTTGATTGGGGCCCCTCCAGGATATGTTGGTTATGATGAAGGTGGTCAATTGACTGAAC
GCGTTCGTAATAAACCCTATTCTGTGGTTCTTTTAGATGAAGTTGAGAAAGCTCATCCTGACGTTTTCAATATCATGCTC
CAAATTTTAGACGATGGATTTGTGACAGATACAAAGGGCCGCAAAGTTGATTTTAGAAACACAATTATTATCATGACTTC
AAACTTGGGTGCAACGGCTCTTCGTGATGATAAAACAGTTGGTTTTGGTGCAAAAAATATCACGGCTGACTACTCAGCTA
TGCAATCAAGAATTTTGGAAGAACTTAAACGTCATTATCGTCCAGAGTTTCTCAATCGTATTGATGAAAACATTGTTTTC
CATTCATTGGAAAGTCAAGAAATTGAACAAATTGTTAAGATTATGAGCAAATCTTTGATTAAACGTTTGGCGGAACAAGA
TATTCATGTGAAACTTACGCCATCAGCAATAAAACTAATCGCTGAAGTAGGATTTGACCCAGAATATGGGGCACGTCCAT
TGCGTAAAGCACTCCAAAAAGAAGTTGAAGATCTTTTAAGTGAACAATTGCTCTCGGGTGAGATTAAAGCAGGAAATCAT
ATTTCCATTGGTGCTTCTAATAAAAAAATTAAAATCGCTCAAATTGTTTGA

Domains

Predicted by InterproScan.

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (723-802)

• AAA lid domain (AAA_lid_9) (357-449)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (96-144)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (19-69)

• ATPase family associated with various cellular activities (AAA) (AAA) (218-334)

• AAA domain (Cdc48 subfamily) (AAA_2) (545-716)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	95.956	100	0.96
clpC	Streptococcus thermophilus LMD-9	51.023	100	0.52
clpC	Streptococcus thermophilus LMG 18311	50.903	100	0.518
clpC	Streptococcus pneumoniae Rx1	49.517	100	0.502
clpC	Streptococcus pneumoniae D39	49.517	100	0.502
clpC	Streptococcus pneumoniae TIGR4	49.396	100	0.501
clpC	Streptococcus mutans UA159	49.038	100	0.5
clpC	Bacillus subtilis subsp. subtilis str. 168	50.249	98.284	0.494
clpE	Streptococcus mutans UA159	46.923	79.657	0.374
clpC	Lactococcus lactis subsp. cremoris KW2	46.626	79.902	0.373
clpE	Streptococcus pneumoniae TIGR4	47.049	76.838	0.362
clpE	Streptococcus pneumoniae Rx1	47.049	76.838	0.362
clpE	Streptococcus pneumoniae D39	47.049	76.838	0.362
clpE	Streptococcus pneumoniae R6	47.049	76.838	0.362