Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   M5S63_RS09880 Genome accession   NZ_CP103521
Coordinates   2052958..2053614 (+) Length   218 a.a.
NCBI ID   WP_000611328.1    Uniprot ID   P66797
Organism   Escherichia coli strain 2779 - blood draw same patient as MB9267     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2047958..2058614
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  M5S63_RS09850 (M5S63_09850) dcyD 2048838..2049824 (+) 987 WP_020232905.1 D-cysteine desulfhydrase -
  M5S63_RS09855 (M5S63_09855) tcyL 2049839..2050507 (+) 669 WP_001158220.1 cystine ABC transporter permease -
  M5S63_RS09860 (M5S63_09860) tcyN 2050504..2051256 (+) 753 WP_001272994.1 L-cystine ABC transporter ATP-binding protein TcyN -
  M5S63_RS09865 (M5S63_09865) sdiA 2051486..2052208 (+) 723 WP_001154271.1 transcriptional regulator SdiA -
  M5S63_RS09870 (M5S63_09870) yecF 2052275..2052499 (-) 225 WP_000106474.1 DUF2594 family protein YecF -
  M5S63_RS09875 (M5S63_09875) yecU 2052486..2052662 (-) 177 WP_000590347.1 protein YecU -
  M5S63_RS09880 (M5S63_09880) letA 2052958..2053614 (+) 657 WP_000611328.1 UvrY/SirA/GacA family response regulator transcription factor Regulator
  M5S63_RS09885 (M5S63_09885) uvrC 2053611..2055443 (+) 1833 WP_001283421.1 excinuclease ABC subunit UvrC Machinery gene
  M5S63_RS09890 (M5S63_09890) pgsA 2055500..2056048 (+) 549 WP_001160187.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
  M5S63_RS09910 (M5S63_09910) yecA 2056698..2057363 (+) 666 WP_000847881.1 UPF0149 family protein YecA -

Sequence

Protein


Download         Length: 218 a.a.        Molecular weight: 23862.63 Da        Isoelectric Point: 6.9614

>NTDB_id=622639 M5S63_RS09880 WP_000611328.1 2052958..2053614(+) (letA) [Escherichia coli strain 2779 - blood draw same patient as MB9267]
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRANAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ

Nucleotide


Download         Length: 657 bp        

>NTDB_id=622639 M5S63_RS09880 WP_000611328.1 2052958..2053614(+) (letA) [Escherichia coli strain 2779 - blood draw same patient as MB9267]
TTGATCAACGTTCTACTTGTTGATGACCACGAACTGGTGCGCGCAGGGATACGACGCATTCTGGAAGATATAAAGGGTAT
AAAAGTCGTCGGTGAGGCATCGTGCGGTGAAGACGCCGTTAAATGGTGCCGGGCAAATGCCGTTGACGTGGTGCTAATGG
ACATGAGTATGCCGGGCATTGGCGGTCTTGAGGCGACGCGTAAAATCGCGCGTTCCACAGCTGATGTCAAAATCATCATG
CTTACCGTCCATACAGAAAACCCTTTACCAGCGAAAGTCATGCAGGCCGGTGCTGCTGGCTACCTCAGCAAAGGCGCGGC
TCCGCAGGAAGTCGTGAGTGCGATCCGTTCTGTCTATTCAGGGCAGCGTTACATTGCTTCTGACATCGCTCAACAAATGG
CGTTAAGCCAGATCGAACCAGAAAAAACAGAAAGCCCATTTGCCAGTTTGTCTGAACGTGAATTGCAGATTATGCTGATG
ATCACCAAGGGCCAGAAGGTCAATGAGATCTCAGAACAGCTCAATCTCAGTCCGAAAACGGTGAACAGCTACCGCTATCG
TATGTTCAGTAAACTAAACATTCATGGCGATGTTGAGCTGACTCACCTGGCAATTCGCCATGGTCTGTGTAATGCGGAGA
CATTATCAAGTCAGTGA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(149-204)

Response regulator receiver domain (Response_reg)

(4-115)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P66797

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

50.725

94.954

0.482
  letA Legionella pneumophila strain ERS1305867

50.725

94.954

0.482