Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpX   Type   Regulator
Locus tag   LK450_RS03185 Genome accession   NZ_CP085939
Coordinates   644450..645682 (-) Length   410 a.a.
NCBI ID   WP_003027977.1    Uniprot ID   I0SHV1
Organism   Streptococcus anginosus subsp. anginosus strain FDAARGOS_1569     
Function   require for competence development (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 628248..647432 644450..645682 within 0


Gene organization within MGE regions


Location: 628248..647432
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  LK450_RS03125 (LK450_03125) - 628248..629888 (-) 1641 WP_003030632.1 hypothetical protein -
  LK450_RS03130 (LK450_03130) - 629878..630621 (-) 744 WP_003030627.1 ABC transporter ATP-binding protein -
  LK450_RS03135 (LK450_03135) - 630749..631289 (-) 541 Protein_620 DUF1697 domain-containing protein -
  LK450_RS03140 (LK450_03140) uvrB 631320..633308 (-) 1989 WP_003030651.1 excinuclease ABC subunit UvrB -
  LK450_RS03145 (LK450_03145) - 633399..634358 (-) 960 WP_003030658.1 CPBP family intramembrane glutamic endopeptidase -
  LK450_RS03150 (LK450_03150) - 634521..636704 (+) 2184 WP_003032255.1 ABC transporter substrate-binding protein/permease -
  LK450_RS03155 (LK450_03155) - 636704..637444 (+) 741 WP_003032251.1 amino acid ABC transporter ATP-binding protein -
  LK450_RS03160 (LK450_03160) - 637820..639355 (+) 1536 WP_003032268.1 ATP-binding cassette domain-containing protein -
  LK450_RS03165 (LK450_03165) - 639376..641124 (-) 1749 WP_003032246.1 ABC transporter ATP-binding protein -
  LK450_RS03170 (LK450_03170) - 641105..642850 (-) 1746 WP_003032265.1 ABC transporter ATP-binding protein -
  LK450_RS03175 (LK450_03175) - 643023..643730 (-) 708 WP_003032270.1 glucosaminidase domain-containing protein -
  LK450_RS03180 (LK450_03180) yihA 643851..644438 (-) 588 WP_003032247.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
  LK450_RS03185 (LK450_03185) clpX 644450..645682 (-) 1233 WP_003027977.1 ATP-dependent Clp protease ATP-binding subunit ClpX Regulator
  LK450_RS03190 (LK450_03190) - 645721..645894 (-) 174 WP_003032252.1 hypothetical protein -
  LK450_RS03195 (LK450_03195) - 645894..646406 (-) 513 WP_003032260.1 dihydrofolate reductase -
  LK450_RS03200 (LK450_03200) - 646593..647432 (-) 840 WP_003032264.1 thymidylate synthase -

Sequence

Protein


Download         Length: 410 a.a.        Molecular weight: 45688.21 Da        Isoelectric Point: 4.4242

>NTDB_id=621390 LK450_RS03185 WP_003027977.1 644450..645682(-) (clpX) [Streptococcus anginosus subsp. anginosus strain FDAARGOS_1569]
MPTNRTNEMMVYCSFCGKSQEEVQKIIAGNNAFICNECVELAQEIIREELAEEVLADLSEVPKPQELLNILNHYVIGQDR
AKRALAVAVYNHYKRINFHDNREDEEDVELQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATALTEAGYVGEDVEN
ILLKLLQAADFNIERAERGIIYVDEIDKIAKKSENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPQQEMIQVDT
KNILFIVGGAFDGIEEIVKQRLGEKIIGFGQNNKAIDETGSYMQEIISEDIQKFGLIPELIGRLPVFAALEPLTVDDLVR
ILREPKNALVKQYQTLLSYDDVKLEFDDDALQEIANKAIERKTGARGLRSIIEETMMDVMFEVPSQENVKLVRITKEAVD
GTDKPILETA

Nucleotide


Download         Length: 1233 bp        

>NTDB_id=621390 LK450_RS03185 WP_003027977.1 644450..645682(-) (clpX) [Streptococcus anginosus subsp. anginosus strain FDAARGOS_1569]
ATGCCTACAAATCGTACGAACGAAATGATGGTTTATTGTTCTTTTTGTGGTAAAAGCCAAGAGGAAGTTCAAAAAATTAT
CGCAGGAAATAATGCCTTCATTTGTAATGAATGTGTGGAATTAGCACAAGAAATTATTAGAGAAGAATTGGCAGAAGAAG
TGCTGGCAGACTTGTCAGAAGTACCAAAACCGCAAGAACTACTCAATATTTTGAATCATTATGTGATTGGACAAGACCGT
GCTAAGCGAGCATTGGCCGTTGCTGTTTACAATCACTATAAACGCATCAATTTTCATGATAATCGTGAAGATGAGGAAGA
TGTCGAATTGCAGAAATCCAATATCCTCATGATTGGGCCAACTGGTTCTGGCAAGACCTTTCTCGCTCAAACTTTGGCAA
AAAGTCTGAATGTTCCTTTTGCGATTGCAGATGCGACAGCTTTGACAGAAGCTGGGTATGTCGGAGAAGATGTTGAAAAT
ATTCTCTTGAAACTCTTGCAAGCAGCAGATTTCAATATTGAGCGTGCTGAACGTGGTATCATCTATGTAGATGAGATTGA
TAAAATTGCGAAGAAAAGCGAAAATGTCTCTATTACTCGTGATGTGTCTGGTGAAGGTGTTCAGCAAGCGCTCCTCAAAA
TTATTGAAGGAACAGTAGCCAGCGTACCTCCGCAAGGCGGCCGCAAGCACCCTCAACAAGAGATGATTCAAGTAGATACG
AAAAATATTCTCTTTATCGTTGGTGGTGCATTTGACGGTATTGAAGAAATTGTCAAACAACGTCTAGGCGAAAAAATTAT
CGGTTTTGGTCAAAACAACAAGGCCATTGATGAAACTGGTTCTTATATGCAAGAAATCATCTCTGAAGATATTCAAAAAT
TTGGCTTGATTCCGGAATTGATTGGTCGTTTGCCTGTGTTTGCAGCGCTTGAGCCTTTAACAGTTGATGATTTGGTGCGA
ATCCTTCGCGAACCAAAGAATGCTTTAGTGAAGCAATATCAGACTCTTCTTTCTTATGATGATGTCAAATTGGAGTTTGA
TGATGATGCTCTCCAAGAGATTGCCAACAAAGCCATTGAACGTAAGACAGGTGCGCGTGGATTGCGGTCGATTATCGAGG
AAACTATGATGGATGTCATGTTTGAAGTTCCAAGTCAAGAAAATGTGAAGTTAGTGCGGATTACCAAGGAAGCAGTTGAC
GGAACGGATAAGCCGATTTTAGAAACAGCATAA

Domains

Predicted by InterproScan.

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(313-390)

ClpX C4-type zinc finger (zf-C4_ClpX)

(12-48)

AAA domain (Cdc48 subfamily) (AAA_2)

(111-306)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB I0SHV1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpX Streptococcus mutans UA159

86.829

100

0.868
  clpX Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819

58.458

98.049

0.573