Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   SIR_RS11515 Genome accession   NC_022246
Coordinates   332873..333562 (+) Length   229 a.a.
NCBI ID   WP_021002458.1    Uniprot ID   T1ZE34
Organism   Streptococcus intermedius B196     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 327873..338562
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SIR_RS11495 (SIR_0344) htpX 328399..329295 (+) 897 WP_009569222.1 zinc metalloprotease HtpX -
  SIR_RS11500 (SIR_0345) - 329398..330624 (-) 1227 WP_021002456.1 hypothetical protein -
  SIR_RS11505 (SIR_0346) - 330812..331348 (+) 537 WP_021002457.1 DUF177 domain-containing protein -
  SIR_RS11510 (SIR_0347) gndA 331440..332864 (+) 1425 WP_006268166.1 NADP-dependent phosphogluconate dehydrogenase -
  SIR_RS11515 (SIR_0348) covR 332873..333562 (+) 690 WP_021002458.1 DNA-binding response regulator Regulator
  SIR_RS11520 (SIR_0349) - 333869..334318 (+) 450 Protein_321 PTS glucose transporter subunit IIA -
  SIR_RS11525 (SIR_0350) - 334530..336719 (+) 2190 WP_021002460.1 PTS transporter subunit IIBC -
  SIR_RS11530 (SIR_0351) - 336737..337552 (+) 816 WP_009569215.1 endonuclease/exonuclease/phosphatase family protein -
  SIR_RS11535 (SIR_0352) - 337603..338085 (-) 483 WP_021002461.1 hypothetical protein -

Sequence

Protein


Download         Length: 229 a.a.        Molecular weight: 26537.56 Da        Isoelectric Point: 6.5002

>NTDB_id=61868 SIR_RS11515 WP_021002458.1 332873..333562(+) (covR) [Streptococcus intermedius B196]
MGKRILLVENEKKIAQFISLELQNEGYRVDLFETGKDALTSARANQYDLFLLNFMLEDMTGTEFAEQLSLIKPASVIIVL
DNRDIILKYTEEIQRFAVSYMIEPFIVMDLVGKISAIFRGRDFIDHHCSQMKVSTSYRNLRIDVQNHTVYRGNEIISLTR
REYDLLATLMGSHQALSREQLLERVWKYEGAVETNVVDVYIRYLRSKLDTAGQKSYIKTVRGVGYAMQE

Nucleotide


Download         Length: 690 bp        

>NTDB_id=61868 SIR_RS11515 WP_021002458.1 332873..333562(+) (covR) [Streptococcus intermedius B196]
ATGGGGAAGCGGATTTTATTAGTTGAGAATGAAAAAAAAATAGCACAATTTATTAGCTTAGAGTTGCAAAATGAAGGTTA
TCGAGTGGATCTTTTTGAAACGGGAAAAGATGCTTTAACATCTGCGAGAGCTAATCAATACGATTTATTCCTGTTAAATT
TTATGCTTGAAGATATGACAGGAACGGAGTTTGCTGAGCAATTAAGTTTGATAAAGCCTGCTTCAGTCATTATTGTATTG
GATAATCGTGATATTATTTTAAAATATACTGAGGAAATCCAACGTTTTGCTGTTAGTTATATGATAGAGCCTTTCATTGT
GATGGACTTGGTCGGAAAAATTTCTGCTATTTTTCGTGGGCGTGATTTTATTGATCATCATTGTAGTCAGATGAAAGTTT
CAACATCTTATCGGAATCTTCGCATTGACGTGCAAAATCATACTGTATATCGAGGGAATGAAATAATTTCTTTGACTAGA
AGAGAGTATGATTTGTTAGCAACGCTGATGGGCAGTCATCAGGCTTTAAGCCGTGAACAGCTGTTAGAGCGCGTTTGGAA
ATACGAAGGAGCTGTCGAGACAAATGTTGTTGATGTCTATATTCGTTATCTTCGTAGTAAACTTGATACAGCAGGGCAGA
AAAGTTACATAAAAACTGTGCGTGGTGTTGGCTATGCTATGCAAGAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-82)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(156-227)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB T1ZE34

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

47.826

100

0.48
  covR Lactococcus lactis subsp. lactis strain DGCC12653

44.737

99.563

0.445

Multiple sequence alignment