Detailed information NTG0061824

Bioinformatically predicted

Overview

• Name: clpX
• Type: Regulator
• Locus tag: SCR2_RS05000
• Genome accession: NC_022245
• Coordinates: 1004687..1005919 (-)
• Length: 410 a.a.
• NCBI ID: WP_006267807.1
• Uniprot ID: F9P6J5
• Organism: Streptococcus constellatus subsp. pharyngis C818
• Function: require for competence development (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Prophage	995584..1007782	1004687..1005919	within	0

Gene organization within MGE regions

Location: 995584..1007782

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SCR2_RS04965 (SCR2_0979)	-	995584..996324 (+)	741	WP_003035612.1	amino acid ABC transporter ATP-binding protein	-
SCR2_RS04970 (SCR2_0980)	-	996741..998276 (+)	1536	Protein_974	ATP-binding cassette domain-containing protein	-
SCR2_RS04975 (SCR2_0981)	-	998395..1000143 (-)	1749	WP_020997827.1	ABC transporter ATP-binding protein	-
SCR2_RS04980 (SCR2_0982)	-	1000133..1001869 (-)	1737	WP_006267937.1	ABC transporter ATP-binding protein	-
SCR2_RS04985 (SCR2_0983)	-	1002083..1002880 (-)	798	WP_020997828.1	formate/nitrite transporter family protein	-
SCR2_RS04990 (SCR2_0984)	-	1003055..1003762 (-)	708	WP_020997829.1	glucosaminidase domain-containing protein	-
SCR2_RS04995 (SCR2_0985)	yihA	1004087..1004674 (-)	588	WP_020997830.1	ribosome biogenesis GTP-binding protein YihA/YsxC	-
SCR2_RS05000 (SCR2_0986)	clpX	1004687..1005919 (-)	1233	WP_006267807.1	ATP-dependent Clp protease ATP-binding subunit ClpX	Regulator
SCR2_RS10405 (SCR2_0987)	-	1005973..1006146 (-)	174	WP_003024903.1	hypothetical protein	-
SCR2_RS05010 (SCR2_0988)	-	1006146..1006658 (-)	513	WP_020997831.1	dihydrofolate reductase	-
SCR2_RS05020 (SCR2_0989)	-	1006943..1007782 (-)	840	WP_006267886.1	thymidylate synthase	-

Sequence

Protein

• Length: 410 a.a.
• Molecular weight: 45672.12 Da
• Isoelectric Point: 4.3966

>NTDB_id=61824 SCR2_RS05000 WP_006267807.1 1004687..1005919(-) (clpX) [Streptococcus constellatus subsp. pharyngis C818]
MPTNRTSEMMVYCSFCGKSQEEVQKIIAGNNAFICNECVELAQEIIREELAEEVLADLSEVPKPQELLNILNHYVIGQDR
AKRALAVAVYNHYKRINFHDNREEEDDVELQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATALTEAGYVGEDVEN
ILLKLLQAADFNIERAERGIIYVDEIDKIAKKSENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPQQEMIQVDT
KNILFIVGGAFDGIEEIVKQRLGEKIIGFGQNNKAIDENSSYMQEIISEDIQKFGLIPELIGRLPVFAALEPLTVEDLVR
ILREPKNALVKQYQTLLSYDDVTLEFDDDALQEIANKAIEHKTGARGLRSIIEETMMDVMFEVPSQENVKLVRITKEAVD
GTDKPILETA

Nucleotide

• Length: 1233 bp

>NTDB_id=61824 SCR2_RS05000 WP_006267807.1 1004687..1005919(-) (clpX) [Streptococcus constellatus subsp. pharyngis C818]
ATGCCTACAAATCGTACGAGCGAAATGATGGTTTATTGTTCTTTTTGTGGTAAAAGTCAAGAAGAAGTTCAAAAAATTAT
TGCAGGAAATAATGCATTTATTTGTAACGAATGTGTGGAATTAGCACAAGAAATTATTAGAGAAGAATTAGCAGAAGAAG
TATTAGCAGACTTGTCGGAAGTACCAAAACCACAAGAATTGCTTAACATTTTAAATCACTATGTAATAGGGCAAGATCGT
GCAAAGCGAGCGCTGGCTGTTGCTGTATACAATCACTATAAACGTATCAATTTTCACGATAATCGTGAAGAAGAGGATGA
TGTCGAATTACAAAAATCCAATATTCTTATGATTGGTCCAACCGGTTCTGGTAAGACTTTTCTTGCTCAAACTTTAGCGA
AAAGTCTAAATGTTCCCTTTGCGATTGCAGATGCGACAGCTTTGACGGAAGCTGGCTATGTGGGGGAAGATGTTGAAAAC
ATTCTCTTAAAACTCTTGCAAGCTGCAGATTTTAATATTGAGCGTGCAGAACGTGGCATTATCTATGTAGATGAGATTGA
CAAAATTGCAAAGAAAAGCGAAAACGTCTCTATTACTCGTGATGTTTCTGGTGAAGGCGTTCAGCAAGCTTTGCTTAAAA
TCATTGAAGGGACTGTAGCTAGTGTACCTCCTCAAGGTGGTCGCAAACATCCACAGCAAGAAATGATTCAAGTGGATACT
AAGAATATTCTTTTTATCGTTGGTGGTGCTTTTGACGGAATTGAAGAAATTGTCAAACAACGTCTAGGTGAAAAGATTAT
TGGTTTTGGTCAAAATAACAAAGCTATTGATGAAAATAGTTCTTATATGCAAGAAATTATTTCCGAAGATATTCAAAAAT
TTGGACTCATCCCCGAATTGATTGGTCGTTTACCAGTGTTTGCTGCGCTTGAGCCTTTGACAGTTGAGGATTTGGTACGA
ATTCTTCGTGAGCCTAAGAATGCTTTAGTGAAACAATATCAAACGCTTCTTTCTTATGACGATGTTACATTAGAGTTTGA
TGATGATGCTCTCCAAGAGATTGCTAACAAAGCTATTGAACACAAGACAGGTGCTCGTGGCTTGCGCTCGATTATCGAAG
AAACCATGATGGATGTCATGTTTGAAGTACCAAGTCAAGAAAATGTGAAGTTAGTGCGGATTACCAAGGAAGCAGTTGAT
GGAACAGATAAACCGATTTTAGAAACAGCTTAA

Domains

Predicted by InterproScan.

• ClpX C4-type zinc finger (zf-C4_ClpX) (12-48)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (313-390)

• AAA domain (Cdc48 subfamily) (AAA_2) (111-306)

3D structure

• AlphaFold DB: F9P6J5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpX	Streptococcus mutans UA159	86.098	100	0.861
clpX	Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819	58.458	98.049	0.573