Detailed information NTG0061502

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: SCRE_RS09725
• Genome accession: NC_022236
• Coordinates: 1933398..1934588 (+)
• Length: 396 a.a.
• NCBI ID: WP_006270334.1
• Uniprot ID: U2XXY1
• Organism: Streptococcus constellatus subsp. pharyngis C232
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1928398..1939588

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SCRE_RS09700 (SCRE_1893)	comE	1930203..1930952 (-)	750	WP_003071650.1	competence system response regulator transcription factor ComE	Regulator
SCRE_RS09705 (SCRE_1894)	comD/comD1	1930952..1932265 (-)	1314	WP_020998131.1	GHKL domain-containing protein	Regulator
SCRE_RS10190 (SCRE_1895)	-	1932285..1932431 (-)	147	WP_006268843.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
SCRE_RS09720 (SCRE_1897)	rlmH	1932714..1933193 (-)	480	WP_006268880.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
SCRE_RS09725 (SCRE_1898)	htrA	1933398..1934588 (+)	1191	WP_006270334.1	S1C family serine protease	Regulator
SCRE_RS09730 (SCRE_1899)	spo0J	1934643..1935410 (+)	768	WP_003071657.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 396 a.a.
• Molecular weight: 41637.72 Da
• Isoelectric Point: 9.8633

>NTDB_id=61502 SCRE_RS09725 WP_006270334.1 1933398..1934588(+) (htrA) [Streptococcus constellatus subsp. pharyngis C232]
MKNSSNFTKKLLWLFMVLAIGFIGGLFGNLTSSKLSTNSSTTTKVNKVTTAYKNTNSTTQAVSKVKDAVVSVITYANNNS
QNSVFGNDDSNTNNDNSQQVASEGSGVIYKKDGKYAYLVTNTHVINGAKKVDIRLADGNKVPGEIIGSDTYSDISVVRIS
ADKVKTVAEFGDSSKLTVGETAIAIGSPLGSNYANTVTQGIISSLNRNVSLKSESGQTISTQAIQTDTAINPGNSGGPLV
NIQGQVIGITSSKIASNGGTSVEGLGFAIPSNDVINIINQLEANGTVTRPALGIQMIDITNLSNSDLSRLKLPSKVTSGV
VVRSAQAGMPAAGKLQKYDVITKVDGKDISSVSDLQSALYKHSIGDDIKITFYRNGKETTTTIKLTKSTKDLDSNN

Nucleotide

• Length: 1191 bp

>NTDB_id=61502 SCRE_RS09725 WP_006270334.1 1933398..1934588(+) (htrA) [Streptococcus constellatus subsp. pharyngis C232]
ATGAAAAATTCTTCAAATTTTACAAAAAAATTATTATGGCTTTTCATGGTCTTAGCTATAGGTTTTATTGGTGGTTTATT
TGGAAACTTAACCTCATCAAAATTATCAACAAATAGTTCTACAACAACTAAGGTTAACAAAGTTACTACTGCTTATAAAA
ATACAAATTCTACAACACAAGCTGTAAGCAAAGTAAAGGATGCAGTTGTATCTGTTATTACCTATGCTAATAATAATTCT
CAAAATAGTGTTTTTGGAAATGATGATTCAAATACTAATAACGATAATTCTCAACAAGTAGCTAGTGAAGGATCTGGGGT
TATTTATAAAAAAGACGGAAAATACGCCTACTTAGTGACCAATACCCATGTTATTAATGGTGCTAAAAAAGTTGATATTC
GTTTGGCTGATGGGAATAAAGTTCCTGGAGAAATTATAGGTTCAGATACTTATTCTGATATCTCTGTTGTTCGTATTAGT
GCTGATAAAGTAAAAACAGTTGCTGAATTTGGAGATTCTAGTAAATTAACTGTTGGTGAAACAGCTATTGCGATTGGAAG
TCCACTCGGATCAAATTATGCTAATACTGTGACACAAGGAATTATTTCTAGCTTAAATCGTAATGTGTCTTTAAAATCTG
AAAGCGGTCAAACTATTTCAACACAAGCTATCCAAACTGATACAGCTATCAATCCAGGGAATTCTGGTGGTCCACTTGTA
AATATCCAAGGACAAGTAATTGGTATTACTTCAAGTAAAATTGCTAGCAACGGTGGAACTTCTGTTGAGGGATTAGGTTT
TGCCATTCCATCTAATGATGTTATTAATATTATCAATCAATTAGAAGCAAACGGAACTGTTACACGACCAGCTCTAGGAA
TCCAAATGATCGACATCACTAATCTGTCTAATTCAGATTTATCACGCTTAAAACTCCCATCCAAAGTAACTAGTGGGGTT
GTTGTACGTTCAGCTCAAGCTGGGATGCCTGCAGCAGGAAAGCTTCAAAAATATGATGTTATTACAAAAGTAGATGGCAA
AGACATTTCCTCAGTAAGTGATTTACAATCTGCTTTATACAAACATTCAATTGGTGATGATATAAAAATTACATTTTATC
GTAATGGAAAAGAAACAACAACTACTATTAAGCTGACAAAATCTACAAAAGATTTAGATTCAAATAATTGA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (104-249)

• PDZ domain (PDZ_2) (290-385)

• Peptidase family M50 (Peptidase_M50) (266-390)

3D structure

• AlphaFold DB: U2XXY1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus gordonii str. Challis substr. CH1	74.25	100	0.75
htrA	Streptococcus mitis NCTC 12261	72.292	100	0.725
htrA	Streptococcus pneumoniae R6	72.04	100	0.722
htrA	Streptococcus pneumoniae TIGR4	72.04	100	0.722
htrA	Streptococcus pneumoniae D39	72.04	100	0.722
htrA	Streptococcus pneumoniae Rx1	72.04	100	0.722
htrA	Streptococcus mutans UA159	55.838	99.495	0.556