Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   NPS18_RS09730 Genome accession   NZ_CP101984
Coordinates   1960627..1962582 (-) Length   651 a.a.
NCBI ID   WP_002262396.1    Uniprot ID   Q8DRX0
Organism   Streptococcus mutans strain UA-159     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 1955627..1967582
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NPS18_RS09705 (NPS18_09705) spx 1956130..1956528 (-) 399 WP_002262391.1 transcriptional regulator Spx -
  NPS18_RS09710 (NPS18_09710) recA 1956613..1957764 (-) 1152 WP_002262392.1 recombinase RecA Machinery gene
  NPS18_RS09715 (NPS18_09715) cinA 1957804..1959060 (-) 1257 WP_002262393.1 competence/damage-inducible protein A Machinery gene
  NPS18_RS09720 (NPS18_09720) - 1959209..1959769 (-) 561 WP_002262394.1 DNA-3-methyladenine glycosylase I -
  NPS18_RS09725 (NPS18_09725) ruvA 1959851..1960444 (-) 594 WP_002262395.1 Holliday junction branch migration protein RuvA Machinery gene
  NPS18_RS09730 (NPS18_09730) hexB 1960627..1962582 (-) 1956 WP_002262396.1 DNA mismatch repair endonuclease MutL Machinery gene
  NPS18_RS09735 (NPS18_09735) - 1962807..1963085 (+) 279 Protein_1867 transposase -
  NPS18_RS09740 (NPS18_09740) hexA 1963080..1965629 (-) 2550 WP_002279585.1 DNA mismatch repair protein MutS Machinery gene
  NPS18_RS09745 (NPS18_09745) - 1965622..1965969 (-) 348 WP_002264540.1 YlbF family regulator -
  NPS18_RS09750 (NPS18_09750) argR 1965966..1966403 (-) 438 WP_002262400.1 arginine repressor -
  NPS18_RS09755 (NPS18_09755) - 1966826..1967323 (-) 498 WP_002262401.1 Crp/Fnr family transcriptional regulator -

Sequence

Protein


Download         Length: 651 a.a.        Molecular weight: 73810.53 Da        Isoelectric Point: 6.3427

>NTDB_id=613682 NPS18_RS09730 WP_002262396.1 1960627..1962582(-) (hexB) [Streptococcus mutans strain UA-159]
MSKIIELPEVLANQIAAGEVIERPASVVKELVENAIDADSSQITIEIEESGLKKIQVTDNGQGIEQADVIMSLRRHATSK
IKKQSDLFRIRTLGFRGEALPSIASISRLTLKTATKGEIYGTLLIANGGKIEKEEAISTPIGTKVSVENLFFNTPARLKY
MKSLQAELAHIIDVINRLSLAHPEIAFTLINDGRELTKTAGKGDLRQALAGIYGVTIAKKMVEISNADLDFEVSGYISLP
ELTRANRNYITILINGRYIKNFLLNRAILDGYGSKLMVGRFPIAVIDIQIDPYLADVNVHPTKQEVRISKEKELMNLVSS
AIADSLREQELIPDALENLAKTSTNKKQKFEQTQLPLKQSNLYYDKTQNDFFLKETTVSEASSEFTVVDKAVNITDNVSG
HSSVKYAQRQMRTCENKEHPSLTMTDKQQKRQLSRIVESLENEEKSTFPELEYFGQMHGTYLFAQGEGGLYIIDQHAAQE
RVKYEYYRDKIGEVDNSLQQLLVPYLFEFPANDFMTLQEKMSILNEVGIHLENYGENTFILREHPIWLQEKEIESAVYEM
CDMLLLTNEVSIKKYRAELAIMMSCKRSIKANHTLDDYSARNLLIQLSQCKNPYNCPHGRPVLVNFTKADMEKMFRRIQE
NHTSLRELGKY

Nucleotide


Download         Length: 1956 bp        

>NTDB_id=613682 NPS18_RS09730 WP_002262396.1 1960627..1962582(-) (hexB) [Streptococcus mutans strain UA-159]
ATGTCAAAAATTATTGAACTGCCAGAAGTTTTAGCCAATCAAATTGCTGCTGGAGAGGTTATTGAAAGACCAGCTAGTGT
CGTAAAAGAACTAGTTGAGAATGCTATTGACGCTGATAGCAGCCAAATTACAATAGAAATTGAAGAATCAGGACTGAAAA
AAATTCAAGTGACTGATAATGGTCAAGGAATAGAACAAGCGGATGTAATTATGAGCTTACGTCGCCATGCAACTAGTAAG
ATTAAAAAACAATCCGATCTTTTTAGAATTAGGACCTTAGGTTTTAGAGGTGAGGCCCTTCCATCAATTGCTTCTATTAG
CAGATTAACATTAAAAACAGCAACAAAAGGGGAAATATATGGCACTTTATTAATCGCAAATGGAGGTAAAATTGAAAAAG
AAGAAGCCATTAGTACCCCTATTGGAACCAAAGTGAGTGTTGAAAATCTTTTCTTCAATACCCCTGCTCGCCTTAAATAT
ATGAAAAGTTTGCAGGCAGAGCTTGCTCATATTATTGATGTCATTAACCGTCTTAGCTTGGCGCATCCCGAAATTGCTTT
CACGCTTATTAATGATGGCCGTGAATTAACAAAGACGGCAGGTAAAGGCGATCTGCGTCAAGCTTTAGCGGGTATTTATG
GGGTAACCATTGCTAAAAAAATGGTCGAAATTTCAAATGCAGATCTTGATTTTGAGGTATCTGGTTATATTAGTTTGCCT
GAATTAACCCGAGCTAATCGCAATTATATTACCATTCTTATTAATGGGCGTTATATCAAAAATTTTTTGCTCAATCGCGC
TATTCTTGATGGTTATGGTTCAAAATTAATGGTGGGACGTTTTCCAATTGCTGTTATTGATATTCAGATTGACCCTTATT
TAGCAGATGTTAATGTTCATCCAACTAAGCAGGAAGTTCGCATTTCTAAAGAAAAAGAGTTAATGAATCTCGTTAGTTCG
GCAATTGCAGATAGTTTAAGAGAACAAGAGTTAATTCCTGATGCTTTGGAAAATCTTGCTAAAACTAGCACAAACAAGAA
ACAAAAGTTTGAACAAACACAGCTTCCTCTTAAACAATCAAATCTTTACTATGATAAGACTCAAAATGACTTCTTTCTCA
AAGAAACGACAGTTTCAGAAGCATCAAGCGAGTTTACAGTAGTTGATAAAGCTGTAAATATTACTGATAATGTATCAGGA
CATAGTAGTGTAAAATATGCTCAACGTCAAATGAGAACTTGTGAAAACAAAGAGCATCCAAGTCTTACTATGACAGATAA
GCAACAAAAGCGACAGCTTAGTAGAATTGTTGAAAGTCTAGAAAATGAAGAAAAGTCAACTTTTCCTGAGTTAGAATATT
TTGGTCAAATGCATGGAACTTACCTCTTTGCTCAAGGTGAAGGGGGGCTTTATATTATAGATCAACATGCTGCTCAAGAA
CGTGTTAAATATGAATATTATCGTGATAAAATTGGAGAAGTAGACAATAGTTTACAGCAGCTTTTAGTACCTTATCTTTT
TGAATTTCCTGCTAATGATTTTATGACCTTACAAGAAAAAATGAGCATTTTAAATGAGGTGGGAATTCACTTAGAAAACT
ATGGAGAGAATACTTTTATTTTGAGGGAACATCCTATTTGGTTACAGGAAAAAGAAATTGAATCAGCCGTTTATGAGATG
TGTGACATGTTGCTGTTGACAAATGAAGTCTCCATTAAGAAATATCGAGCGGAATTAGCTATTATGATGTCTTGCAAGCG
TTCTATCAAGGCTAATCATACTTTGGATGATTATTCTGCCAGAAATCTCTTAATTCAATTATCACAGTGCAAAAATCCTT
ACAATTGTCCTCATGGACGTCCTGTGCTTGTGAATTTCACAAAAGCTGATATGGAAAAGATGTTTCGTCGCATTCAGGAA
AACCATACTAGTTTGAGAGAATTAGGGAAATACTGA

Domains

Predicted by InterProScan.

MutL C terminal dimerisation domain (MutL_C)

(453-595)

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(210-326)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-136)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q8DRX0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

70.213

100

0.71