Detailed information    

insolico Bioinformatically predicted

Overview

Name   comGE   Type   Machinery gene
Locus tag   NPS18_RS09180 Genome accession   NZ_CP101984
Coordinates   1853499..1853792 (-) Length   97 a.a.
NCBI ID   WP_002263439.1    Uniprot ID   Q8DS53
Organism   Streptococcus mutans strain UA-159     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1848499..1858792
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NPS18_RS09145 (NPS18_09145) - 1848507..1849169 (-) 663 WP_002263446.1 type II CAAX endopeptidase family protein -
  NPS18_RS09150 (NPS18_09150) - 1849222..1849662 (-) 441 WP_002263445.1 hypothetical protein -
  NPS18_RS09155 (NPS18_09155) - 1849631..1849876 (-) 246 WP_002263444.1 helix-turn-helix transcriptional regulator -
  NPS18_RS09160 (NPS18_09160) - 1850445..1851644 (-) 1200 WP_002263443.1 acetate kinase -
  NPS18_RS09165 (NPS18_09165) comGH 1851703..1852656 (-) 954 WP_002263442.1 class I SAM-dependent methyltransferase Machinery gene
  NPS18_RS09170 (NPS18_09170) comGG 1852711..1853100 (-) 390 WP_002263441.1 competence type IV pilus minor pilin ComGG Machinery gene
  NPS18_RS09175 (NPS18_09175) comGF 1853078..1853512 (-) 435 WP_002263440.1 competence type IV pilus minor pilin ComGF Machinery gene
  NPS18_RS09180 (NPS18_09180) comGE 1853499..1853792 (-) 294 WP_002263439.1 competence type IV pilus minor pilin ComGE Machinery gene
  NPS18_RS09185 (NPS18_09185) comGD 1853764..1854168 (-) 405 WP_002263438.1 competence type IV pilus minor pilin ComGD Machinery gene
  NPS18_RS09190 (NPS18_09190) comGC 1854155..1854469 (-) 315 WP_002263437.1 competence type IV pilus major pilin ComGC Machinery gene
  NPS18_RS09195 (NPS18_09195) comGB 1854469..1855500 (-) 1032 WP_255262721.1 competence type IV pilus assembly protein ComGB Machinery gene
  NPS18_RS09200 (NPS18_09200) comGA 1855436..1856377 (-) 942 WP_002263435.1 competence type IV pilus ATPase ComGA Machinery gene
  NPS18_RS09205 (NPS18_09205) - 1856507..1856890 (-) 384 WP_002263434.1 DUF1033 family protein -

Sequence

Protein


Download         Length: 97 a.a.        Molecular weight: 11001.91 Da        Isoelectric Point: 9.4908

>NTDB_id=613666 NPS18_RS09180 WP_002263439.1 1853499..1853792(-) (comGE) [Streptococcus mutans strain UA-159]
MVSIKKQKVKAYILLESLVALGLFVTITTLILTQLSHYQERTAKNLQKQEILNLAIMALQTQQDHLSFNGVSVTVVKNQG
ETIVYHDHEEVINLVKK

Nucleotide


Download         Length: 294 bp        

>NTDB_id=613666 NPS18_RS09180 WP_002263439.1 1853499..1853792(-) (comGE) [Streptococcus mutans strain UA-159]
GTGGTCAGTATAAAAAAACAGAAAGTTAAAGCTTATATTCTTCTAGAAAGTTTAGTTGCTTTGGGGCTTTTCGTAACCAT
CACAACTTTAATTCTTACTCAGTTGAGTCATTATCAGGAAAGAACAGCTAAAAATTTACAAAAACAAGAAATATTGAATT
TAGCAATAATGGCTCTTCAAACTCAGCAAGATCATTTAAGCTTCAACGGCGTCAGTGTTACGGTTGTTAAAAATCAAGGG
GAAACTATAGTTTATCATGATCATGAGGAGGTTATCAATCTTGTTAAAAAGTAA

Domains

Predicted by InterProScan.

Type II secretory pathway pseudopilin (ComGE)

(13-94)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q8DS53

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comGE Streptococcus mutans UA140

100

100

1
  comGE Streptococcus mutans UA159

100

100

1
  comGE/cglE Streptococcus pneumoniae Rx1

44.444

92.784

0.412
  comGE/cglE Streptococcus pneumoniae D39

44.444

92.784

0.412
  comGE/cglE Streptococcus pneumoniae R6

44.444

92.784

0.412
  comGE/cglE Streptococcus pneumoniae TIGR4

44.444

92.784

0.412
  comGE/cglE Streptococcus mitis NCTC 12261

44.444

92.784

0.412
  comGE/cglE Streptococcus mitis SK321

44.444

92.784

0.412