Detailed information NTG0611378

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: LE189_RS09300
• Genome accession: NZ_CP084444
• Coordinates: 1951095..1952138 (+)
• Length: 347 a.a.
• NCBI ID: WP_002461334.1
• Uniprot ID: A0A853V5Y6
• Organism: Staphylococcus lugdunensis strain RMLUG6
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1946095..1957138

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LE189_RS09275 (LE189_09270)	-	1946385..1947746 (-)	1362	WP_037540479.1	FAD-dependent oxidoreductase	-
LE189_RS09280 (LE189_09275)	-	1947880..1948860 (-)	981	WP_002492696.1	FUSC family protein	-
LE189_RS09285 (LE189_09280)	map	1949105..1949860 (+)	756	WP_002461338.1	type I methionyl aminopeptidase	-
LE189_RS09290 (LE189_09285)	-	1949986..1950372 (+)	387	WP_002477960.1	hypothetical protein	-
LE189_RS09295 (LE189_09290)	liaF	1950397..1951098 (+)	702	WP_002461335.1	cell wall-active antibiotics response protein LiaF	-
LE189_RS09300 (LE189_09295)	vraS	1951095..1952138 (+)	1044	WP_002461334.1	sensor histidine kinase	Regulator
LE189_RS09305 (LE189_09300)	vraR	1952128..1952757 (+)	630	WP_002461333.1	two-component system response regulator VraR	Regulator
LE189_RS09310 (LE189_09305)	-	1952930..1954159 (-)	1230	WP_002492699.1	YihY/virulence factor BrkB family protein	-
LE189_RS09315 (LE189_09310)	-	1954362..1954646 (-)	285	WP_002461330.1	YtxH domain-containing protein	-
LE189_RS09320 (LE189_09315)	-	1954653..1955117 (-)	465	WP_002492719.1	low molecular weight protein-tyrosine-phosphatase	-
LE189_RS09325 (LE189_09320)	-	1955281..1955466 (+)	186	WP_002492715.1	DUF1128 domain-containing protein	-
LE189_RS09330 (LE189_09325)	-	1955536..1956717 (+)	1182	WP_207754594.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 39934.41 Da
• Isoelectric Point: 5.9679

>NTDB_id=611378 LE189_RS09300 WP_002461334.1 1951095..1952138(+) (vraS) [Staphylococcus lugdunensis strain RMLUG6]
MNHYIRAIGSMLILVYSLMIAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLVIILLCIIVGSILAFKINQQNDWIKT
QVEHAIEGETVGINDQNIELYNETIDLYHTLVPLNQELHRLRMKTQNLTNENYNLNDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETELEPPLDQQIPVLEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHDI
EEFKVPKGLEDHLFRITQEAISNTLRHSKGTKVTVELFNKADYLLLRIQDNGIGFNVDDKVEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSHDN

Nucleotide

• Length: 1044 bp

>NTDB_id=611378 LE189_RS09300 WP_002461334.1 1951095..1952138(+) (vraS) [Staphylococcus lugdunensis strain RMLUG6]
ATGAACCACTATATTCGAGCAATCGGCTCAATGTTGATACTAGTGTATAGCTTAATGATTGCTTTTCTGTTTATTGATAA
AGTATTCGTTAATATCATTTACTTTCAAGGCATGTTTTATACACAAATATTTGGAATACCAGTATTCCTTTTCTTAAATT
TGGTTATTATTTTATTATGTATTATTGTGGGCTCTATATTAGCTTTTAAAATCAATCAACAAAATGATTGGATCAAAACA
CAAGTAGAGCATGCAATAGAAGGGGAAACAGTTGGTATAAATGATCAAAATATAGAATTGTATAATGAAACAATTGATTT
ATATCATACATTAGTTCCCTTAAATCAAGAGTTACACCGATTAAGAATGAAAACACAAAACTTAACAAATGAAAATTATA
ATTTAAATGATGTAAAAGTGAAAAAAATAATTGAAGACGAACGTCAACGTCTAGCTCGAGAATTACATGATTCAGTGAGC
CAGCAATTATTTGCAGCCAGTATGATGTTATCTGCAATTAAAGAAACAGAGCTAGAACCACCTTTAGATCAACAAATTCC
AGTTTTAGAAAAAATGGTGCAAGATTCACAACTTGAAATGAGAGCACTCTTATTACATCTAAGACCAATTGGTTTAAAGG
ACAAGTCGTTGGGTGAAGGTATTAAAGATTTAGTCATCGATTTACAGAAAAAAGTACCGATGAAAGTGGTTCACGATATT
GAAGAATTTAAAGTGCCTAAAGGTTTAGAAGATCATTTGTTTAGAATTACTCAAGAAGCCATCTCTAATACTTTAAGACA
TTCAAAAGGAACTAAAGTTACTGTAGAATTATTTAATAAAGCAGATTATTTATTATTAAGAATACAAGATAATGGCATTG
GATTTAATGTTGATGATAAAGTCGAACAAAGTTATGGCTTGAAAAATATGCGCGAACGTGCGTTAGAAATAGGTGCAACA
TTTCATATTGTATCATTGCCTGATTCTGGAACAAGAATAGAGGTTAAAGCACCGTTAAACAAGGAGGATTCACATGACAA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A853V5Y6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	91.066	100	0.911