Detailed information NTG0611322

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: LE164_RS11260
• Genome accession: NZ_CP084440
• Coordinates: 2382881..2383924 (-)
• Length: 347 a.a.
• NCBI ID: WP_002461334.1
• Uniprot ID: A0A853V5Y6
• Organism: Staphylococcus lugdunensis strain RMLUG4
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2377881..2388924

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LE164_RS11230 (LE164_11245)	-	2378302..2379540 (-)	1239	WP_002477963.1	aminopeptidase	-
LE164_RS11235 (LE164_11250)	-	2379553..2379738 (-)	186	WP_002492715.1	DUF1128 domain-containing protein	-
LE164_RS11240 (LE164_11255)	-	2379902..2380366 (+)	465	WP_002477961.1	low molecular weight protein-tyrosine-phosphatase	-
LE164_RS11245 (LE164_11260)	-	2380373..2380657 (+)	285	WP_002461330.1	YtxH domain-containing protein	-
LE164_RS11250 (LE164_11265)	-	2380860..2382089 (+)	1230	WP_002461332.1	YihY/virulence factor BrkB family protein	-
LE164_RS11255 (LE164_11270)	vraR	2382262..2382891 (-)	630	WP_002461333.1	two-component system response regulator VraR	Regulator
LE164_RS11260 (LE164_11275)	vraS	2382881..2383924 (-)	1044	WP_002461334.1	sensor histidine kinase	Regulator
LE164_RS11265 (LE164_11280)	liaF	2383921..2384622 (-)	702	WP_002461335.1	cell wall-active antibiotics response protein LiaF	-
LE164_RS11270 (LE164_11285)	-	2384647..2385033 (-)	387	WP_002477960.1	hypothetical protein	-
LE164_RS11275 (LE164_11290)	map	2385159..2385914 (-)	756	WP_002461338.1	type I methionyl aminopeptidase	-
LE164_RS11280 (LE164_11295)	-	2386159..2387139 (+)	981	WP_002477959.1	aromatic acid exporter family protein	-
LE164_RS11285 (LE164_11300)	-	2387273..2388634 (+)	1362	WP_002477958.1	FAD-dependent oxidoreductase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 39934.41 Da
• Isoelectric Point: 5.9679

>NTDB_id=611322 LE164_RS11260 WP_002461334.1 2382881..2383924(-) (vraS) [Staphylococcus lugdunensis strain RMLUG4]
MNHYIRAIGSMLILVYSLMIAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLVIILLCIIVGSILAFKINQQNDWIKT
QVEHAIEGETVGINDQNIELYNETIDLYHTLVPLNQELHRLRMKTQNLTNENYNLNDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETELEPPLDQQIPVLEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHDI
EEFKVPKGLEDHLFRITQEAISNTLRHSKGTKVTVELFNKADYLLLRIQDNGIGFNVDDKVEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSHDN

Nucleotide

• Length: 1044 bp

>NTDB_id=611322 LE164_RS11260 WP_002461334.1 2382881..2383924(-) (vraS) [Staphylococcus lugdunensis strain RMLUG4]
ATGAACCACTATATTCGAGCAATCGGCTCAATGTTGATACTAGTGTATAGCTTAATGATTGCTTTTCTGTTTATTGATAA
AGTATTCGTTAATATCATTTACTTTCAAGGCATGTTTTATACACAAATATTTGGAATACCAGTATTCCTTTTCTTAAATT
TGGTTATTATTTTATTATGTATTATTGTGGGCTCTATATTAGCTTTTAAAATCAATCAACAAAATGATTGGATCAAAACA
CAAGTAGAGCATGCAATAGAAGGGGAAACAGTTGGTATAAATGATCAAAATATAGAATTGTATAATGAAACAATTGATTT
ATATCATACATTAGTTCCCTTAAATCAAGAGTTACACCGATTAAGAATGAAAACACAAAACTTAACAAATGAAAATTATA
ATTTAAATGATGTAAAAGTGAAAAAAATAATTGAAGACGAACGTCAACGTCTAGCTCGAGAATTACATGATTCAGTGAGC
CAGCAATTATTTGCAGCCAGTATGATGTTATCTGCAATTAAAGAAACAGAGCTAGAACCACCTTTAGATCAACAAATTCC
AGTTTTAGAAAAAATGGTGCAAGATTCACAACTTGAAATGAGAGCGCTCTTATTACATCTAAGACCAATTGGTTTAAAGG
ACAAGTCGTTGGGTGAAGGTATTAAAGATTTAGTCATCGATTTACAGAAAAAAGTACCGATGAAAGTGGTTCACGATATT
GAAGAATTTAAAGTGCCTAAAGGTTTAGAAGATCATTTGTTTAGAATTACTCAAGAAGCCATCTCTAATACTTTAAGACA
TTCAAAAGGAACTAAAGTTACTGTAGAATTATTTAATAAAGCAGATTATTTATTATTAAGAATACAAGATAATGGCATTG
GATTTAATGTTGATGATAAAGTCGAACAAAGTTATGGCTTGAAAAATATGCGCGAACGTGCGTTAGAAATAGGTGCAACA
TTTCATATTGTATCATTGCCTGATTCTGGAACAAGAATAGAGGTTAAAGCACCGTTAAACAAGGAGGATTCACATGACAA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A853V5Y6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	91.066	100	0.911