Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   NMK58_RS18370 Genome accession   NZ_CP101292
Coordinates   3525422..3526078 (-) Length   218 a.a.
NCBI ID   WP_000611328.1    Uniprot ID   P66797
Organism   Escherichia coli strain 2003-3014     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 3520422..3531078
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NMK58_RS18340 (NMK58_18340) yecA 3521673..3522338 (-) 666 WP_000847902.1 UPF0149 family protein YecA -
  NMK58_RS18360 (NMK58_18360) pgsA 3522988..3523536 (-) 549 WP_001160187.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
  NMK58_RS18365 (NMK58_18365) uvrC 3523593..3525425 (-) 1833 WP_001283424.1 excinuclease ABC subunit UvrC Machinery gene
  NMK58_RS18370 (NMK58_18370) letA 3525422..3526078 (-) 657 WP_000611328.1 UvrY/SirA/GacA family response regulator transcription factor Regulator
  NMK58_RS30785 - 3526220..3526336 (+) 117 WP_001302039.1 hypothetical protein -
  NMK58_RS18375 (NMK58_18375) yecU 3526374..3526550 (+) 177 WP_001342215.1 protein YecU -
  NMK58_RS18380 (NMK58_18380) yecF 3526537..3526761 (+) 225 WP_000106474.1 DUF2594 family protein YecF -
  NMK58_RS18385 (NMK58_18385) sdiA 3526829..3527551 (-) 723 WP_001154265.1 transcriptional regulator SdiA -
  NMK58_RS18390 (NMK58_18390) tcyN 3527781..3528533 (-) 753 WP_001272994.1 L-cystine ABC transporter ATP-binding protein TcyN -
  NMK58_RS18395 (NMK58_18395) tcyL 3528530..3529198 (-) 669 WP_001158220.1 cystine ABC transporter permease -
  NMK58_RS18400 (NMK58_18400) dcyD 3529213..3530199 (-) 987 WP_001128238.1 D-cysteine desulfhydrase -

Sequence

Protein


Download         Length: 218 a.a.        Molecular weight: 23862.63 Da        Isoelectric Point: 6.9614

>NTDB_id=610118 NMK58_RS18370 WP_000611328.1 3525422..3526078(-) (letA) [Escherichia coli strain 2003-3014]
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRANAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ

Nucleotide


Download         Length: 657 bp        

>NTDB_id=610118 NMK58_RS18370 WP_000611328.1 3525422..3526078(-) (letA) [Escherichia coli strain 2003-3014]
TTGATCAACGTTCTACTTGTTGATGACCACGAACTGGTGCGCGCAGGGATACGACGCATTCTGGAAGATATAAAGGGTAT
AAAAGTCGTCGGTGAGGCATCGTGCGGTGAAGACGCCGTTAAGTGGTGTCGGGCAAATGCCGTTGACGTGGTGCTAATGG
ACATGAGTATGCCGGGCATTGGCGGTCTTGAGGCGACGCGTAAAATCGCGCGTTCCACAGCTGATGTCAAAATCATCATG
CTTACCGTCCATACAGAAAACCCTTTACCAGCGAAAGTCATGCAGGCCGGTGCTGCGGGCTACCTCAGCAAAGGCGCGGC
TCCGCAGGAAGTCGTGAGTGCGATTCGTTCTGTCTATTCAGGGCAGCGTTACATTGCTTCTGACATCGCTCAACAAATGG
CGTTAAGCCAGATCGAACCAGAAAAAACAGAAAGCCCATTTGCCAGTTTGTCTGAACGTGAATTGCAGATTATGCTGATG
ATCACCAAGGGCCAGAAGGTCAATGAGATCTCAGAACAGCTCAATCTCAGTCCGAAAACGGTGAACAGCTACCGCTATCG
TATGTTCAGTAAACTAAACATTCATGGCGATGTTGAGCTGACTCACCTGGCAATTCGCCATGGTCTGTGTAATGCGGAGA
CATTATCAAGTCAGTGA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(149-204)

Response regulator receiver domain (Response_reg)

(4-115)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P66797

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

50.725

94.954

0.482
  letA Legionella pneumophila strain ERS1305867

50.725

94.954

0.482