Detailed information NTG0609592

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: LB316_RS09635
• Genome accession: NZ_CP084107
• Coordinates: 1962164..1963207 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain CC49/ST49-MSSA
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1957164..1968207

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LB316_RS09605 (LB316_09600)	-	1957585..1958841 (-)	1257	WP_078064589.1	aminopeptidase	-
LB316_RS09610 (LB316_09605)	-	1958844..1959044 (-)	201	WP_000180460.1	DUF1128 family protein	-
LB316_RS09615 (LB316_09610)	-	1959191..1959655 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
LB316_RS09620 (LB316_09615)	-	1959662..1959937 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
LB316_RS09625 (LB316_09620)	-	1960215..1961432 (+)	1218	WP_000037087.1	YihY/virulence factor BrkB family protein	-
LB316_RS09630 (LB316_09625)	vraR	1961545..1962174 (-)	630	WP_000153526.1	two-component system response regulator VraR	Regulator
LB316_RS09635 (LB316_09630)	vraS	1962164..1963207 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
LB316_RS09640 (LB316_09635)	liaF	1963204..1963905 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
LB316_RS09645 (LB316_09640)	-	1963920..1964306 (-)	387	WP_001110179.1	hypothetical protein	-
LB316_RS09650 (LB316_09645)	map	1964523..1965281 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
LB316_RS09655 (LB316_09650)	-	1965693..1966679 (+)	987	WP_000999715.1	aromatic acid exporter family protein	-
LB316_RS09660 (LB316_09655)	-	1966868..1967281 (-)	414	WP_025174552.1	hypothetical protein	-
LB316_RS09665 (LB316_09660)	-	1967310..1967420 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=609592 LB316_RS09635 WP_001017131.1 1962164..1963207(-) (vraS) [Staphylococcus aureus strain CC49/ST49-MSSA]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=609592 LB316_RS09635 WP_001017131.1 1962164..1963207(-) (vraS) [Staphylococcus aureus strain CC49/ST49-MSSA]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAACGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTTGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTCAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1