Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   EL277_RS02005 Genome accession   NZ_AP018936
Coordinates   374194..374826 (+) Length   210 a.a.
NCBI ID   WP_000698434.1    Uniprot ID   Q9S1J7
Organism   Streptococcus pneumoniae strain NU83127     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 369194..379826
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL277_RS01980 (SPNU_0370) mvaD 369472..370425 (+) 954 WP_000373455.1 diphosphomevalonate decarboxylase -
  EL277_RS01985 (SPNU_0371) - 370412..371419 (+) 1008 WP_000562415.1 phosphomevalonate kinase -
  EL277_RS01990 (SPNU_0372) fni 371403..372413 (+) 1011 WP_000210618.1 type 2 isopentenyl-diphosphate Delta-isomerase -
  EL277_RS01995 (SPNU_0373) liaF 372490..373188 (+) 699 WP_001224636.1 cell wall-active antibiotics response protein LiaF -
  EL277_RS02000 (SPNU_0374) - 373185..374180 (+) 996 WP_000743672.1 sensor histidine kinase -
  EL277_RS02005 (SPNU_0375) vraR 374194..374826 (+) 633 WP_000698434.1 response regulator transcription factor Regulator
  EL277_RS12160 - 374902..375595 (+) 694 Protein_377 DNA alkylation repair protein -
  EL277_RS02025 (SPNU_0377) - 375745..375984 (+) 240 WP_000754501.1 hypothetical protein -
  EL277_RS02030 (SPNU_0378) cbpG 376065..376886 (+) 822 WP_001100143.1 choline-binding protein CbpG -
  EL277_RS02035 (SPNU_0379) cbpF 376905..377927 (+) 1023 WP_000771060.1 choline-binding protein CbpF -
  EL277_RS02040 - 378055..379395 (-) 1341 Protein_381 IS3 family transposase -

Sequence

Protein


Download         Length: 210 a.a.        Molecular weight: 23553.03 Da        Isoelectric Point: 4.5791

>NTDB_id=60955 EL277_RS02005 WP_000698434.1 374194..374826(+) (vraR) [Streptococcus pneumoniae strain NU83127]
MKILLVDDHEMVRLGLKSYFDLQDDVEVVGEASNGSQGIDLALELRPDVIVMDIVMPEMNGIDATLAILKEWPEAKILIV
TSYLDNEKIMPVLDAGAKGYMLKTSSADELLHAVSKVAAGELAIEQEVSKKVEYHRNHMELHEELTARERDVLQLIAKGY
ENQRIADDLFISLKTVKTHVSNILAKLEVSDRTQAAVYAFQHHLVGQEEF

Nucleotide


Download         Length: 633 bp        

>NTDB_id=60955 EL277_RS02005 WP_000698434.1 374194..374826(+) (vraR) [Streptococcus pneumoniae strain NU83127]
ATGAAAATTTTACTAGTAGATGACCATGAAATGGTCCGATTGGGCTTGAAAAGCTACTTTGACCTCCAAGACGATGTAGA
AGTTGTGGGTGAGGCGTCCAACGGGTCTCAAGGGATTGACTTGGCCTTGGAACTGCGTCCAGATGTCATTGTCATGGATA
TTGTCATGCCTGAGATGAATGGGATTGACGCGACCTTAGCAATCCTTAAAGAATGGCCTGAAGCCAAGATTTTGATTGTG
ACCTCTTATTTGGACAATGAAAAAATCATGCCAGTCTTAGATGCTGGTGCCAAAGGCTATATGCTCAAGACTTCTAGTGC
AGATGAATTGCTTCATGCCGTCAGTAAGGTAGCTGCTGGCGAGCTGGCCATTGAGCAAGAGGTTAGCAAGAAGGTTGAAT
ACCACCGCAATCATATGGAACTTCATGAAGAATTGACTGCGCGTGAGCGAGATGTTCTCCAACTCATCGCCAAGGGCTAC
GAAAATCAGCGCATCGCAGATGACCTCTTTATCTCTCTCAAGACGGTCAAGACCCACGTGTCCAATATTCTTGCCAAACT
TGAAGTCAGCGATCGTACCCAGGCGGCTGTCTATGCCTTTCAGCACCATTTGGTGGGGCAAGAGGAGTTTTAG

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(145-199)

Response regulator receiver domain (Response_reg)

(3-114)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9S1J7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.153

99.524

0.519
  degU Bacillus subtilis subsp. subtilis str. 168

38.393

100

0.41

Multiple sequence alignment